Prevalence of high N-terminal prohormone of brain natriuretic peptide levels and associated factors among community-dwelling older adults aged over 75 years (The SONIC study): a cross-sectional study

Abstract Objectives Considering the heart failure (HF) pandemic, numerous older adults in the community may exhibit potential cardiac overload or asymptomatic HF without apparent HF diagnosis. This study aimed to examine the distribution of serum N-terminal prohormone of brain natriuretic peptide (N...

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Main Authors: Saya Terada, Kayo Godai, Mai Kabayama, Michiko Kido, Yuya Akagi, Hiroshi Akasaka, Yoichi Takami, Takeshi Nakagawa, Saori Yasumoto, Yasuyuki Gondo, Kazunori Ikebe, Yasumichi Arai, Yukie Masui, Takumi Hirata, Koichi Yamamoto, Kei Kamide
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Research Notes
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Online Access:https://doi.org/10.1186/s13104-025-07280-6
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author Saya Terada
Kayo Godai
Mai Kabayama
Michiko Kido
Yuya Akagi
Hiroshi Akasaka
Yoichi Takami
Takeshi Nakagawa
Saori Yasumoto
Yasuyuki Gondo
Kazunori Ikebe
Yasumichi Arai
Yukie Masui
Takumi Hirata
Koichi Yamamoto
Kei Kamide
author_facet Saya Terada
Kayo Godai
Mai Kabayama
Michiko Kido
Yuya Akagi
Hiroshi Akasaka
Yoichi Takami
Takeshi Nakagawa
Saori Yasumoto
Yasuyuki Gondo
Kazunori Ikebe
Yasumichi Arai
Yukie Masui
Takumi Hirata
Koichi Yamamoto
Kei Kamide
author_sort Saya Terada
collection DOAJ
description Abstract Objectives Considering the heart failure (HF) pandemic, numerous older adults in the community may exhibit potential cardiac overload or asymptomatic HF without apparent HF diagnosis. This study aimed to examine the distribution of serum N-terminal prohormone of brain natriuretic peptide (NT-proBNP) levels in community-dwelling old age adults aged ≥ 75 years, and to investigate the associated factors for each NT-proBNP classification. Results A cross-sectional analysis revealed that 52.0% of 611 participants had NT-proBNP ≥ 125 pg/mL. Multinomial logistic regression analysis showed that female sex, older age (80s and 90s), and uncontrolled high blood pressure were significantly associated with 125 ≤ NT-proBNP < 300 pg/mL, while older age (80s and 90s), coronary artery disease, atrial fibrillation, and renal dysfunction were significantly associated with NT-proBNP ≥ 300 pg/mL. Independent association between higher salt intake and NT-proBNP ≥ 300 pg/mL was also observed. Appropriate management of common HF risk factors, such as uncontrolled high blood pressure and high salt intake, is crucial to prevent the progression of overt HF.
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spelling doaj-art-3c7747ed80824d6099889f2ee1fde9f52025-08-20T01:52:25ZengBMCBMC Research Notes1756-05002025-05-011811910.1186/s13104-025-07280-6Prevalence of high N-terminal prohormone of brain natriuretic peptide levels and associated factors among community-dwelling older adults aged over 75 years (The SONIC study): a cross-sectional studySaya Terada0Kayo Godai1Mai Kabayama2Michiko Kido3Yuya Akagi4Hiroshi Akasaka5Yoichi Takami6Takeshi Nakagawa7Saori Yasumoto8Yasuyuki Gondo9Kazunori Ikebe10Yasumichi Arai11Yukie Masui12Takumi Hirata13Koichi Yamamoto14Kei Kamide15Department of Health Sciences, University of Osaka Graduate School of MedicineDepartment of Health Sciences, University of Osaka Graduate School of MedicineDepartment of Health Sciences, University of Osaka Graduate School of MedicineDepartment of Health Sciences, University of Osaka Graduate School of MedicineDepartment of Health Sciences, University of Osaka Graduate School of MedicineDepartment of Geriatric and General Medicine, University of Osaka Graduate School of MedicineDepartment of Geriatric and General Medicine, University of Osaka Graduate School of MedicineDepartment of Clinical Thanatology and Geriatric Behavioral Sciences, Graduate School of Human Sciences, University of OsakaOffice of International Exchange, University of Osaka Graduate School of Human SciencesDepartment of Clinical Thanatology and Geriatric Behavioral Sciences, Graduate School of Human Sciences, University of OsakaFaculty of Dentistry, University of Osaka Graduate School of DentistryCenter for Supercentenarian Medical Research, Keio University School of MedicineResearch Team for Human Care, Tokyo Metropolitan Institute for Geriatrics and GerontologyResearch Team for Human Care, Tokyo Metropolitan Institute for Geriatrics and GerontologyDepartment of Geriatric and General Medicine, University of Osaka Graduate School of MedicineDepartment of Health Sciences, University of Osaka Graduate School of MedicineAbstract Objectives Considering the heart failure (HF) pandemic, numerous older adults in the community may exhibit potential cardiac overload or asymptomatic HF without apparent HF diagnosis. This study aimed to examine the distribution of serum N-terminal prohormone of brain natriuretic peptide (NT-proBNP) levels in community-dwelling old age adults aged ≥ 75 years, and to investigate the associated factors for each NT-proBNP classification. Results A cross-sectional analysis revealed that 52.0% of 611 participants had NT-proBNP ≥ 125 pg/mL. Multinomial logistic regression analysis showed that female sex, older age (80s and 90s), and uncontrolled high blood pressure were significantly associated with 125 ≤ NT-proBNP < 300 pg/mL, while older age (80s and 90s), coronary artery disease, atrial fibrillation, and renal dysfunction were significantly associated with NT-proBNP ≥ 300 pg/mL. Independent association between higher salt intake and NT-proBNP ≥ 300 pg/mL was also observed. Appropriate management of common HF risk factors, such as uncontrolled high blood pressure and high salt intake, is crucial to prevent the progression of overt HF.https://doi.org/10.1186/s13104-025-07280-6NT-proBNPOlder adultsAging populationCommunityHeart failureCardiac overload
spellingShingle Saya Terada
Kayo Godai
Mai Kabayama
Michiko Kido
Yuya Akagi
Hiroshi Akasaka
Yoichi Takami
Takeshi Nakagawa
Saori Yasumoto
Yasuyuki Gondo
Kazunori Ikebe
Yasumichi Arai
Yukie Masui
Takumi Hirata
Koichi Yamamoto
Kei Kamide
Prevalence of high N-terminal prohormone of brain natriuretic peptide levels and associated factors among community-dwelling older adults aged over 75 years (The SONIC study): a cross-sectional study
BMC Research Notes
NT-proBNP
Older adults
Aging population
Community
Heart failure
Cardiac overload
title Prevalence of high N-terminal prohormone of brain natriuretic peptide levels and associated factors among community-dwelling older adults aged over 75 years (The SONIC study): a cross-sectional study
title_full Prevalence of high N-terminal prohormone of brain natriuretic peptide levels and associated factors among community-dwelling older adults aged over 75 years (The SONIC study): a cross-sectional study
title_fullStr Prevalence of high N-terminal prohormone of brain natriuretic peptide levels and associated factors among community-dwelling older adults aged over 75 years (The SONIC study): a cross-sectional study
title_full_unstemmed Prevalence of high N-terminal prohormone of brain natriuretic peptide levels and associated factors among community-dwelling older adults aged over 75 years (The SONIC study): a cross-sectional study
title_short Prevalence of high N-terminal prohormone of brain natriuretic peptide levels and associated factors among community-dwelling older adults aged over 75 years (The SONIC study): a cross-sectional study
title_sort prevalence of high n terminal prohormone of brain natriuretic peptide levels and associated factors among community dwelling older adults aged over 75 years the sonic study a cross sectional study
topic NT-proBNP
Older adults
Aging population
Community
Heart failure
Cardiac overload
url https://doi.org/10.1186/s13104-025-07280-6
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