Lysine crotonylation in disease: mechanisms, biological functions and therapeutic targets
Abstract Lysine crotonylation (Kcr), a previously unknown post-translational modification (PTM), plays crucial roles in regulating cellular processes, including gene expression, chromatin remodeling, and cellular metabolism. Kcr is associated with various diseases, including neurodegenerative disord...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | Epigenetics & Chromatin |
| Online Access: | https://doi.org/10.1186/s13072-025-00577-7 |
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| _version_ | 1849389858710093824 |
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| author | Yu Ji Shanshan Liu Yiqiao Zhang Yiyang Min Luyang Wei Chengjian Guan Huajing Yu Zhongtao Zhang |
| author_facet | Yu Ji Shanshan Liu Yiqiao Zhang Yiyang Min Luyang Wei Chengjian Guan Huajing Yu Zhongtao Zhang |
| author_sort | Yu Ji |
| collection | DOAJ |
| description | Abstract Lysine crotonylation (Kcr), a previously unknown post-translational modification (PTM), plays crucial roles in regulating cellular processes, including gene expression, chromatin remodeling, and cellular metabolism. Kcr is associated with various diseases, including neurodegenerative disorders, cancer, cardiovascular conditions, and metabolic syndromes. Despite advances in identifying crotonylation sites and their regulatory enzymes, the molecular mechanisms by which Kcr influences disease progression remain poorly understood. Understanding the interplay between Kcr and other acylation modifications may reveal opportunities for developing targeted therapies. This review synthesizes current research on Kcr, focusing on its regulatory mechanisms and disease associations, and highlights insights into future exploration in epigenetics and therapeutic interventions. |
| format | Article |
| id | doaj-art-3c6d08becc744d87b04dde9ee11046b9 |
| institution | Kabale University |
| issn | 1756-8935 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Epigenetics & Chromatin |
| spelling | doaj-art-3c6d08becc744d87b04dde9ee11046b92025-08-20T03:41:50ZengBMCEpigenetics & Chromatin1756-89352025-03-0118112210.1186/s13072-025-00577-7Lysine crotonylation in disease: mechanisms, biological functions and therapeutic targetsYu Ji0Shanshan Liu1Yiqiao Zhang2Yiyang Min3Luyang Wei4Chengjian Guan5Huajing Yu6Zhongtao Zhang7Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & State Key Lab of Digestive Health & National Clinical Research Center for Digestive DiseasesDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University & State Key Lab of Digestive Health & National Clinical Research Center for Digestive DiseasesDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University & State Key Lab of Digestive Health & National Clinical Research Center for Digestive DiseasesDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University & State Key Lab of Digestive Health & National Clinical Research Center for Digestive DiseasesDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University & State Key Lab of Digestive Health & National Clinical Research Center for Digestive DiseasesDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University & State Key Lab of Digestive Health & National Clinical Research Center for Digestive DiseasesDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University & State Key Lab of Digestive Health & National Clinical Research Center for Digestive DiseasesDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University & State Key Lab of Digestive Health & National Clinical Research Center for Digestive DiseasesAbstract Lysine crotonylation (Kcr), a previously unknown post-translational modification (PTM), plays crucial roles in regulating cellular processes, including gene expression, chromatin remodeling, and cellular metabolism. Kcr is associated with various diseases, including neurodegenerative disorders, cancer, cardiovascular conditions, and metabolic syndromes. Despite advances in identifying crotonylation sites and their regulatory enzymes, the molecular mechanisms by which Kcr influences disease progression remain poorly understood. Understanding the interplay between Kcr and other acylation modifications may reveal opportunities for developing targeted therapies. This review synthesizes current research on Kcr, focusing on its regulatory mechanisms and disease associations, and highlights insights into future exploration in epigenetics and therapeutic interventions.https://doi.org/10.1186/s13072-025-00577-7 |
| spellingShingle | Yu Ji Shanshan Liu Yiqiao Zhang Yiyang Min Luyang Wei Chengjian Guan Huajing Yu Zhongtao Zhang Lysine crotonylation in disease: mechanisms, biological functions and therapeutic targets Epigenetics & Chromatin |
| title | Lysine crotonylation in disease: mechanisms, biological functions and therapeutic targets |
| title_full | Lysine crotonylation in disease: mechanisms, biological functions and therapeutic targets |
| title_fullStr | Lysine crotonylation in disease: mechanisms, biological functions and therapeutic targets |
| title_full_unstemmed | Lysine crotonylation in disease: mechanisms, biological functions and therapeutic targets |
| title_short | Lysine crotonylation in disease: mechanisms, biological functions and therapeutic targets |
| title_sort | lysine crotonylation in disease mechanisms biological functions and therapeutic targets |
| url | https://doi.org/10.1186/s13072-025-00577-7 |
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