Integrating single-cell and bulk RNA sequencing data to characterize the heterogeneity of glycan-lipid metabolism polarization in hepatocellular carcinoma

Integrating single-cell and bulk RNA sequencing data to characterize the heterogeneity of glycan-lipid metabolism polarization in hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) is high heterogeneity and remains an unmet medical challenge, but their metabolic heterogeneity has not been fully uncovered and required clinical applicable translational strategies. Methods By analyzing the RNA sequencing data in the in-house coho...

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Bibliographic Details
Main Authors: Peng Lin, Qiong Qin, Xiang-yu Gan, Jin-shu Pang, Rong Wen, Yun He, Hong Yang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
Hepatocellular carcinoma
Metabolic heterogeneity
Multi-omics
Translational medicine
Online Access:https://doi.org/10.1186/s12967-025-06347-z
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