A Finnish nationwide population-based study on the survival of patients with peripheral T-cell lymphoma
Abstract Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of rare malignancies with poor survival; however, population-based long-term survival data remain limited. We conducted a nationwide study to estimate overall survival (OS) and relative survival (RS) among 915 patients diag...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-12596-1 |
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| Summary: | Abstract Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of rare malignancies with poor survival; however, population-based long-term survival data remain limited. We conducted a nationwide study to estimate overall survival (OS) and relative survival (RS) among 915 patients diagnosed with PTCLs from 2002 − 2018 (57% males, median age 67 years) using the Finnish Cancer Registry. The most common subtypes included PTCL not otherwise specified (PTCL NOS; 37%), angioimmunoblastic T-cell lymphoma (AITL; 27%), and ALK-anaplastic large cell lymphoma (ALK-ALCL; 12%). Age > 60 years at diagnosis, advanced stage, and male sex were associated with poorer OS. Five-year OS and RS were better in patients with ALK + ALCL compared with PTCL NOS (5-year OS: 85% vs 30%). Patients with ALK- ALCL had a favorable 5-year OS compared to PTCL NOS (46% vs 30%), while those with enteropathy-associated T-cell lymphoma (EATL) demonstrated worse OS (15%). There was no improvement in RS from 2002 − 2012 to 2013 − 2018. OS was better in patients (excluding ALK + ALCL) receiving high-dose chemotherapy (HDCT) compared to those for whom HDCT was not planned (HR 0.61; 95% CI 0.47 − 0.80). We conclude that RS did not improve during the study period; however, consolidation with HDCT for eligible patients resulted in favorable survival. |
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| ISSN: | 2045-2322 |