[18F]FET PET-Guided management of pseudoprogression in glioblastoma (FET POPPING): the study protocol for a diagnostic randomized clinical trial

[18F]FET PET-Guided management of pseudoprogression in glioblastoma (FET POPPING): the study protocol for a diagnostic randomized clinical trial

Abstract Background During follow-up of glioblastoma patients after chemoradiation, expert teams often observe abnormalities on MRI with difficulty in distinguishing between tumor growth and pseudoprogression. Although advanced MRI techniques such as perfusion weighted imaging provide additional inf...

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Main Authors: V.J. Ruijters, T.J. Snijders, J.A.J. van der Pol, E.M. van de Giessen, J.M. Niers, M.P.G. Broen, M.M. Anten, S.E.M. Veldhuijzen van Zanten, M. Geurts, A.I.J. Arens, D.J.H.A. Henssen, J.M. Gijtenbeek, M. van der Meulen, A.E.J. Sijben, E. Ghariq, M.J. Vos, J. Tim, I.B. Bosma, G.N. Stormezand, G.W.J. Frederix, J.W. Dankbaar, P.A. Robe, J.J.C. Verhoeff, F.Y.F.L. de Vos, M.G.E.H. Lam, R.M.T. ten Ham, N. Tolboom
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Trials
Subjects:
Glioblastoma
GBM
Nuclear medicine
Neuro-oncology
[18F]FET PET
Tumor progression
Online Access:https://doi.org/10.1186/s13063-025-08921-8
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