Search for surrogate markers to predict end stage kidney disease in long term lithium users
Abstract Background A surrogate marker (a substitute indicator of the true outcome) is needed to predict subgroups of long-term lithium users at risk of end-stage kidney disease (ESKD). In this narrative review the aim is to determine the optimal surrogate endpoint for ESKD in long-term lithium user...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2025-01-01
|
| Series: | International Journal of Bipolar Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40345-024-00368-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850099551447285760 |
|---|---|
| author | M. J. van der Aa A. A. Bonenkamp U. M. H. Klumpers R. W. Kupka T. Nijenhuis A. P. M. Kerckhoffs |
| author_facet | M. J. van der Aa A. A. Bonenkamp U. M. H. Klumpers R. W. Kupka T. Nijenhuis A. P. M. Kerckhoffs |
| author_sort | M. J. van der Aa |
| collection | DOAJ |
| description | Abstract Background A surrogate marker (a substitute indicator of the true outcome) is needed to predict subgroups of long-term lithium users at risk of end-stage kidney disease (ESKD). In this narrative review the aim is to determine the optimal surrogate endpoint for ESKD in long-term lithium users in a scientific context. Main In a literature search in long-term lithium users, no studies on surrogate measurements on ESKD were identified. Therefore, comparable ESKD populations were sought, based on baseline eGFR, age, somatic comorbidity and sex. Articles were scored on comparability and risk of bias. Seventeen studies were included; ten studies evaluated a percentual decline (between 20 and 50% decline in eGFR) and seven studies focused upon a declining slope (from 1.63 to 6 ml/min/1,73m2 decline per year), using an interval of one to five years. Study populations mostly included patients with cardiovascular disease and chronic kidney disease. Conclusion Currently, the most appropriate marker for ESKD in long term lithium users appears a 30% decline in eGFR in at least one year. In order to confirm this hypothesis, further research in a cohort of long-term lithium users is needed. Better feasible research on lithium induced nephropathy could result in more knowledge about the risk on kidney function decline in lithium users and guide clinical decision making on lithium use. |
| format | Article |
| id | doaj-art-3c640ca952f24df182c69022c02d4e36 |
| institution | DOAJ |
| issn | 2194-7511 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | International Journal of Bipolar Disorders |
| spelling | doaj-art-3c640ca952f24df182c69022c02d4e362025-08-20T02:40:28ZengSpringerOpenInternational Journal of Bipolar Disorders2194-75112025-01-0113111010.1186/s40345-024-00368-1Search for surrogate markers to predict end stage kidney disease in long term lithium usersM. J. van der Aa0A. A. Bonenkamp1U. M. H. Klumpers2R. W. Kupka3T. Nijenhuis4A. P. M. Kerckhoffs5Department of Psychiatry, Amsterdam University Medical Center Location Vrije UniversiteitDepartment of Nephrology, Jeroen Bosch ZiekenhuisDepartment of Psychiatry, Amsterdam University Medical Center Location Vrije UniversiteitDepartment of Psychiatry, Amsterdam University Medical Center Location Vrije UniversiteitDepartment of Nephrology, Radboud University Medical Center, Radboudumc Institute for Medical InnovationsDepartment of Nephrology, Jeroen Bosch ZiekenhuisAbstract Background A surrogate marker (a substitute indicator of the true outcome) is needed to predict subgroups of long-term lithium users at risk of end-stage kidney disease (ESKD). In this narrative review the aim is to determine the optimal surrogate endpoint for ESKD in long-term lithium users in a scientific context. Main In a literature search in long-term lithium users, no studies on surrogate measurements on ESKD were identified. Therefore, comparable ESKD populations were sought, based on baseline eGFR, age, somatic comorbidity and sex. Articles were scored on comparability and risk of bias. Seventeen studies were included; ten studies evaluated a percentual decline (between 20 and 50% decline in eGFR) and seven studies focused upon a declining slope (from 1.63 to 6 ml/min/1,73m2 decline per year), using an interval of one to five years. Study populations mostly included patients with cardiovascular disease and chronic kidney disease. Conclusion Currently, the most appropriate marker for ESKD in long term lithium users appears a 30% decline in eGFR in at least one year. In order to confirm this hypothesis, further research in a cohort of long-term lithium users is needed. Better feasible research on lithium induced nephropathy could result in more knowledge about the risk on kidney function decline in lithium users and guide clinical decision making on lithium use.https://doi.org/10.1186/s40345-024-00368-1LithiumChronic kidney disease (CKD)Maintenance treatmentGlomerular filtration rateKidney end pointSurrogate end point |
| spellingShingle | M. J. van der Aa A. A. Bonenkamp U. M. H. Klumpers R. W. Kupka T. Nijenhuis A. P. M. Kerckhoffs Search for surrogate markers to predict end stage kidney disease in long term lithium users International Journal of Bipolar Disorders Lithium Chronic kidney disease (CKD) Maintenance treatment Glomerular filtration rate Kidney end point Surrogate end point |
| title | Search for surrogate markers to predict end stage kidney disease in long term lithium users |
| title_full | Search for surrogate markers to predict end stage kidney disease in long term lithium users |
| title_fullStr | Search for surrogate markers to predict end stage kidney disease in long term lithium users |
| title_full_unstemmed | Search for surrogate markers to predict end stage kidney disease in long term lithium users |
| title_short | Search for surrogate markers to predict end stage kidney disease in long term lithium users |
| title_sort | search for surrogate markers to predict end stage kidney disease in long term lithium users |
| topic | Lithium Chronic kidney disease (CKD) Maintenance treatment Glomerular filtration rate Kidney end point Surrogate end point |
| url | https://doi.org/10.1186/s40345-024-00368-1 |
| work_keys_str_mv | AT mjvanderaa searchforsurrogatemarkerstopredictendstagekidneydiseaseinlongtermlithiumusers AT aabonenkamp searchforsurrogatemarkerstopredictendstagekidneydiseaseinlongtermlithiumusers AT umhklumpers searchforsurrogatemarkerstopredictendstagekidneydiseaseinlongtermlithiumusers AT rwkupka searchforsurrogatemarkerstopredictendstagekidneydiseaseinlongtermlithiumusers AT tnijenhuis searchforsurrogatemarkerstopredictendstagekidneydiseaseinlongtermlithiumusers AT apmkerckhoffs searchforsurrogatemarkerstopredictendstagekidneydiseaseinlongtermlithiumusers |