STANDARDIZATION OF FLOW CYTOMETRIC MINIMAL RESIDUAL DISEASE MONITORING IN CHILDREN WITH B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA. RUSSIA–BELARUS MULTICENTER GROUP EXPERIENCE
We developed and implemented in multicenter setting the standardized approach for flow cytometric minimal residual disease (MRD) monitoring in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Participation of multicenter group reference laboratories in several ring trial studies d...
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| Language: | Russian |
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2017-01-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/218 |
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| author | A. M. Popov M. V. Belevtsev E. V. Boyakova T. Yu. Verzhbitskaya L. V. Movchan M. S. Fadeeva А. B. Pashchenko V. P. Savitskiy А. A. Levadnyy G. А. Tsaur S. A. Kashpor S. A. Plyasunova L. G. Fechina O. V. Aleynikova A. I. Karachunskiy |
| author_facet | A. M. Popov M. V. Belevtsev E. V. Boyakova T. Yu. Verzhbitskaya L. V. Movchan M. S. Fadeeva А. B. Pashchenko V. P. Savitskiy А. A. Levadnyy G. А. Tsaur S. A. Kashpor S. A. Plyasunova L. G. Fechina O. V. Aleynikova A. I. Karachunskiy |
| author_sort | A. M. Popov |
| collection | DOAJ |
| description | We developed and implemented in multicenter setting the standardized approach for flow cytometric minimal residual disease (MRD) monitoring in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Participation of multicenter group reference laboratories in several ring trial studies demonstrated high concordance rate between participants. Successful integration of one additional laboratory in the multicenter group has shown good level of our approach reproducibility. These results will allow implementing MRD detection in stratification system of pediatric ALL treatment protocols of Russia-Belarus multicenter group. |
| format | Article |
| id | doaj-art-3c5cd98211d04789a620de530334df1a |
| institution | DOAJ |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2017-01-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-3c5cd98211d04789a620de530334df1a2025-08-20T03:01:03ZrusABV-pressОнкогематология1818-83462413-40232017-01-01114647310.17650/1818-8346-2016-11-4-64-73219STANDARDIZATION OF FLOW CYTOMETRIC MINIMAL RESIDUAL DISEASE MONITORING IN CHILDREN WITH B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA. RUSSIA–BELARUS MULTICENTER GROUP EXPERIENCEA. M. Popov0M. V. Belevtsev1E. V. Boyakova2T. Yu. Verzhbitskaya3L. V. Movchan4M. S. Fadeeva5А. B. Pashchenko6V. P. Savitskiy7А. A. Levadnyy8G. А. Tsaur9S. A. Kashpor10S. A. Plyasunova11L. G. Fechina12O. V. Aleynikova13A. I. Karachunskiy14Federal Research Centre of Pediatric Hematology, Oncology, and Immunology named after Dmitriy RogachevRepublican Center for Pediatric Oncology, Hematology and ImmunologyFederal Research Centre of Pediatric Hematology, Oncology, and Immunology named after Dmitriy Rogachev; The Blood Transfusion Station of the Moscow Healthcare DepartmentRegional Children Clinical Hospital No 1; Research Institute of Medical Cell TechnologiesRepublican Center for Pediatric Oncology, Hematology and ImmunologyFederal Research Centre of Pediatric Hematology, Oncology, and Immunology named after Dmitriy RogachevFederal Research Centre of Pediatric Hematology, Oncology, and Immunology named after Dmitriy RogachevRepublican Center for Pediatric Oncology, Hematology and ImmunologyRepublican Center for Pediatric Oncology, Hematology and ImmunologyRegional Children Clinical Hospital No 1; Research Institute of Medical Cell TechnologiesFederal Research Centre of Pediatric Hematology, Oncology, and Immunology named after Dmitriy RogachevFederal Research Centre of Pediatric Hematology, Oncology, and Immunology named after Dmitriy RogachevRegional Children Clinical Hospital No 1Republican Center for Pediatric Oncology, Hematology and ImmunologyFederal Research Centre of Pediatric Hematology, Oncology, and Immunology named after Dmitriy Rogachev; N.I. Pirogov Russian National Research Medical UniversityWe developed and implemented in multicenter setting the standardized approach for flow cytometric minimal residual disease (MRD) monitoring in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Participation of multicenter group reference laboratories in several ring trial studies demonstrated high concordance rate between participants. Successful integration of one additional laboratory in the multicenter group has shown good level of our approach reproducibility. These results will allow implementing MRD detection in stratification system of pediatric ALL treatment protocols of Russia-Belarus multicenter group.https://oncohematology.abvpress.ru/ongm/article/view/218minimal residual diseaseflow cytometrystandardization |
| spellingShingle | A. M. Popov M. V. Belevtsev E. V. Boyakova T. Yu. Verzhbitskaya L. V. Movchan M. S. Fadeeva А. B. Pashchenko V. P. Savitskiy А. A. Levadnyy G. А. Tsaur S. A. Kashpor S. A. Plyasunova L. G. Fechina O. V. Aleynikova A. I. Karachunskiy STANDARDIZATION OF FLOW CYTOMETRIC MINIMAL RESIDUAL DISEASE MONITORING IN CHILDREN WITH B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA. RUSSIA–BELARUS MULTICENTER GROUP EXPERIENCE Онкогематология minimal residual disease flow cytometry standardization |
| title | STANDARDIZATION OF FLOW CYTOMETRIC MINIMAL RESIDUAL DISEASE MONITORING IN CHILDREN WITH B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA. RUSSIA–BELARUS MULTICENTER GROUP EXPERIENCE |
| title_full | STANDARDIZATION OF FLOW CYTOMETRIC MINIMAL RESIDUAL DISEASE MONITORING IN CHILDREN WITH B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA. RUSSIA–BELARUS MULTICENTER GROUP EXPERIENCE |
| title_fullStr | STANDARDIZATION OF FLOW CYTOMETRIC MINIMAL RESIDUAL DISEASE MONITORING IN CHILDREN WITH B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA. RUSSIA–BELARUS MULTICENTER GROUP EXPERIENCE |
| title_full_unstemmed | STANDARDIZATION OF FLOW CYTOMETRIC MINIMAL RESIDUAL DISEASE MONITORING IN CHILDREN WITH B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA. RUSSIA–BELARUS MULTICENTER GROUP EXPERIENCE |
| title_short | STANDARDIZATION OF FLOW CYTOMETRIC MINIMAL RESIDUAL DISEASE MONITORING IN CHILDREN WITH B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA. RUSSIA–BELARUS MULTICENTER GROUP EXPERIENCE |
| title_sort | standardization of flow cytometric minimal residual disease monitoring in children with b cell precursor acute lymphoblastic leukemia russia belarus multicenter group experience |
| topic | minimal residual disease flow cytometry standardization |
| url | https://oncohematology.abvpress.ru/ongm/article/view/218 |
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