Low-coverage whole genome sequencing of cell-free DNA to predict and track immunotherapy response in advanced non-small cell lung cancer

Low-coverage whole genome sequencing of cell-free DNA to predict and track immunotherapy response in advanced non-small cell lung cancer

Abstract Background Outcomes under anti-PD-(L)1 therapy have been variable in advanced non-small cell lung cancer (NSCLC) without reliable predictive biomarkers so far. Targeted next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) has demonstrated potential clinical utility to support c...

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Bibliographic Details
Main Authors: Florian Janke, Mateo Gasser, Arlou K. Angeles, Anja L. Riediger, Magdalena Görtz, Louise Appenheimer, Astrid K. Laut, Simon Ogrodnik, Sabrina Gerhardt, Albrecht Stenzinger, Marc A. Schneider, Michael Thomas, Petros Christopoulos, Holger Sültmann
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Liquid biopsy
Non-small cell lung cancer
Immunotherapy
Response prediction
Copy number variations
CfDNA fragmentation
Online Access:https://doi.org/10.1186/s13046-025-03348-0
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