Association of Childhood IgA Vasculitis With Allergic Rhinitis and Chronic Rhinosinusitis
Introduction: Immunoglobulin A vasculitis (IgAV) is related to chronic inflammation; however, little is known about the associations between IgAV and allergic rhinitis (AR) or chronic rhinosinusitis (CRS). We evaluated the relationships among IgAV, AR, and CRS in children. Methods: The clinical data...
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| Language: | English |
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Elsevier
2024-09-01
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| Series: | Kidney International Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468024924018199 |
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| author | Weilin Xiong Qingjun Zhu Xiaolei Hu Yehong Yuan Yongwang Zhao Xiaoping Jing Qingyin Guo |
| author_facet | Weilin Xiong Qingjun Zhu Xiaolei Hu Yehong Yuan Yongwang Zhao Xiaoping Jing Qingyin Guo |
| author_sort | Weilin Xiong |
| collection | DOAJ |
| description | Introduction: Immunoglobulin A vasculitis (IgAV) is related to chronic inflammation; however, little is known about the associations between IgAV and allergic rhinitis (AR) or chronic rhinosinusitis (CRS). We evaluated the relationships among IgAV, AR, and CRS in children. Methods: The clinical data of children with IgAV who were hospitalized from January to December 2019 were analyzed retrospectively. Four groups were created, the simple AR, simple CRS, AR + CRS, and non-AR or non-CRS groups, to explore the relationships among IgAV, AR, and CRS. Results: We included 504 children with IgAV; and 357 (70.8%) were combined with AR or CRS, including 51 with simple AR, 70 with simple CRS, and 236 with AR + CRS. The incidences of renal involvement and recurrent rash were significantly higher in the simple AR group than in the non-AR or non-CRS group (P < 0.001). The incidences of renal involvement and recurrent rash were significantly higher in the AR + CRS group than in the non-AR or non-CRS group (P < 0.001). The incidences of renal involvement between the simple CRS group and non-AR or non-CRS group did not differ significantly, but that of recurrent rash was significantly higher than that in the other groups (P < 0.001). Age, abdominal pain, recurrent rash, simple AR, and AR combined with CRS were risk factors for renal involvement (all odds ratio [OR] > 1, P < 0.05). Conclusion: Chronic rhinitis may be related to the pathogenesis of IgAV, and AR or CRS may be the triggering factors of IgAV. AR may be a risk factor for renal involvement and recurrent rash in patients with IgAV. |
| format | Article |
| id | doaj-art-3c5302a13f9f4e6683e017ec6864cf47 |
| institution | OA Journals |
| issn | 2468-0249 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney International Reports |
| spelling | doaj-art-3c5302a13f9f4e6683e017ec6864cf472025-08-20T02:33:36ZengElsevierKidney International Reports2468-02492024-09-01992759276610.1016/j.ekir.2024.07.003Association of Childhood IgA Vasculitis With Allergic Rhinitis and Chronic RhinosinusitisWeilin Xiong0Qingjun Zhu1Xiaolei Hu2Yehong Yuan3Yongwang Zhao4Xiaoping Jing5Qingyin Guo6Pediatric Hospital of the First affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China; Department of Pediatrics, Henan University of Traditional Chinese Medicine, Zhengzhou, ChinaDepartment of Scientific Research, Henan University of Traditional Chinese Medicine, Zhengzhou, ChinaDepartment of Pediatrics, Yinchuan First People’s Hospital, Yinchuan, ChinaPediatric Hospital of the First affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China; Department of Pediatrics, Henan University of Traditional Chinese Medicine, Zhengzhou, ChinaPediatric Hospital of the First affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China; Department of Pediatrics, Henan University of Traditional Chinese Medicine, Zhengzhou, ChinaDepartment of Traditional Chinese Medicine, Shanghai Children’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Correspondence: Xiaoping Jing, Department of Traditional Chinese Medicine, Shanghai Children’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200040, China.Pediatric Hospital of the First affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China; Department of Pediatrics, Henan University of Traditional Chinese Medicine, Zhengzhou, China; Qingyin Guo, School of Pediatrics, Henan University of Traditional Chinese Medicine. Department of Pediatrics, Henan University of Traditional Chinese Medicine, Zhengzhou 450003, China.Introduction: Immunoglobulin A vasculitis (IgAV) is related to chronic inflammation; however, little is known about the associations between IgAV and allergic rhinitis (AR) or chronic rhinosinusitis (CRS). We evaluated the relationships among IgAV, AR, and CRS in children. Methods: The clinical data of children with IgAV who were hospitalized from January to December 2019 were analyzed retrospectively. Four groups were created, the simple AR, simple CRS, AR + CRS, and non-AR or non-CRS groups, to explore the relationships among IgAV, AR, and CRS. Results: We included 504 children with IgAV; and 357 (70.8%) were combined with AR or CRS, including 51 with simple AR, 70 with simple CRS, and 236 with AR + CRS. The incidences of renal involvement and recurrent rash were significantly higher in the simple AR group than in the non-AR or non-CRS group (P < 0.001). The incidences of renal involvement and recurrent rash were significantly higher in the AR + CRS group than in the non-AR or non-CRS group (P < 0.001). The incidences of renal involvement between the simple CRS group and non-AR or non-CRS group did not differ significantly, but that of recurrent rash was significantly higher than that in the other groups (P < 0.001). Age, abdominal pain, recurrent rash, simple AR, and AR combined with CRS were risk factors for renal involvement (all odds ratio [OR] > 1, P < 0.05). Conclusion: Chronic rhinitis may be related to the pathogenesis of IgAV, and AR or CRS may be the triggering factors of IgAV. AR may be a risk factor for renal involvement and recurrent rash in patients with IgAV.http://www.sciencedirect.com/science/article/pii/S2468024924018199allergic rhinitischildrenchronic rhinosinusitisIgA vasculitisretrospective study |
| spellingShingle | Weilin Xiong Qingjun Zhu Xiaolei Hu Yehong Yuan Yongwang Zhao Xiaoping Jing Qingyin Guo Association of Childhood IgA Vasculitis With Allergic Rhinitis and Chronic Rhinosinusitis Kidney International Reports allergic rhinitis children chronic rhinosinusitis IgA vasculitis retrospective study |
| title | Association of Childhood IgA Vasculitis With Allergic Rhinitis and Chronic Rhinosinusitis |
| title_full | Association of Childhood IgA Vasculitis With Allergic Rhinitis and Chronic Rhinosinusitis |
| title_fullStr | Association of Childhood IgA Vasculitis With Allergic Rhinitis and Chronic Rhinosinusitis |
| title_full_unstemmed | Association of Childhood IgA Vasculitis With Allergic Rhinitis and Chronic Rhinosinusitis |
| title_short | Association of Childhood IgA Vasculitis With Allergic Rhinitis and Chronic Rhinosinusitis |
| title_sort | association of childhood iga vasculitis with allergic rhinitis and chronic rhinosinusitis |
| topic | allergic rhinitis children chronic rhinosinusitis IgA vasculitis retrospective study |
| url | http://www.sciencedirect.com/science/article/pii/S2468024924018199 |
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