Relationships between Bone Turnover and Energy Metabolism
It is well established that diabetes can be detrimental to bone health, and its chronic complications have been associated with an increased risk of osteoporotic fracture. However, there is growing evidence that the skeleton plays a key role in a whole-organism approach to physiology. The hypothesis...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/9021314 |
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| author | Tânia A. P. Fernandes Luísa M. L. Gonçalves José A. A. Brito |
| author_facet | Tânia A. P. Fernandes Luísa M. L. Gonçalves José A. A. Brito |
| author_sort | Tânia A. P. Fernandes |
| collection | DOAJ |
| description | It is well established that diabetes can be detrimental to bone health, and its chronic complications have been associated with an increased risk of osteoporotic fracture. However, there is growing evidence that the skeleton plays a key role in a whole-organism approach to physiology. The hypothesis that bone may be involved in the regulation of physiological functions, such as insulin sensitivity and energy metabolism, has been suggested. Given the roles of insulin, adipokines, and osteocalcin in these pathways, the need for a more integrative conceptual approach to physiology is emphasized. Recent findings suggest that bone plays an important role in regulating intermediary metabolism, being possibly both a target of diabetic complications and a potential pathophysiologic factor in the disease itself. Understanding the relationships between bone turnover and glucose metabolism is important in order to develop treatments that might reestablish energy metabolism and bone health. This review describes new insights relating bone turnover and energy metabolism that have been reported in the literature. |
| format | Article |
| id | doaj-art-3c4eae0427e841c3bf37a53042ffac75 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-3c4eae0427e841c3bf37a53042ffac752025-08-20T02:08:18ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/90213149021314Relationships between Bone Turnover and Energy MetabolismTânia A. P. Fernandes0Luísa M. L. Gonçalves1José A. A. Brito2Instituto Superior de Ciências da Saúde Egas Moniz (ISCSEM), Campus Universitário-Quinta da Granja, 2829-511 Monte de Caparica, PortugalInstituto Superior de Ciências da Saúde Egas Moniz (ISCSEM), Campus Universitário-Quinta da Granja, 2829-511 Monte de Caparica, PortugalInstituto Superior de Ciências da Saúde Egas Moniz (ISCSEM), Campus Universitário-Quinta da Granja, 2829-511 Monte de Caparica, PortugalIt is well established that diabetes can be detrimental to bone health, and its chronic complications have been associated with an increased risk of osteoporotic fracture. However, there is growing evidence that the skeleton plays a key role in a whole-organism approach to physiology. The hypothesis that bone may be involved in the regulation of physiological functions, such as insulin sensitivity and energy metabolism, has been suggested. Given the roles of insulin, adipokines, and osteocalcin in these pathways, the need for a more integrative conceptual approach to physiology is emphasized. Recent findings suggest that bone plays an important role in regulating intermediary metabolism, being possibly both a target of diabetic complications and a potential pathophysiologic factor in the disease itself. Understanding the relationships between bone turnover and glucose metabolism is important in order to develop treatments that might reestablish energy metabolism and bone health. This review describes new insights relating bone turnover and energy metabolism that have been reported in the literature.http://dx.doi.org/10.1155/2017/9021314 |
| spellingShingle | Tânia A. P. Fernandes Luísa M. L. Gonçalves José A. A. Brito Relationships between Bone Turnover and Energy Metabolism Journal of Diabetes Research |
| title | Relationships between Bone Turnover and Energy Metabolism |
| title_full | Relationships between Bone Turnover and Energy Metabolism |
| title_fullStr | Relationships between Bone Turnover and Energy Metabolism |
| title_full_unstemmed | Relationships between Bone Turnover and Energy Metabolism |
| title_short | Relationships between Bone Turnover and Energy Metabolism |
| title_sort | relationships between bone turnover and energy metabolism |
| url | http://dx.doi.org/10.1155/2017/9021314 |
| work_keys_str_mv | AT taniaapfernandes relationshipsbetweenboneturnoverandenergymetabolism AT luisamlgoncalves relationshipsbetweenboneturnoverandenergymetabolism AT joseaabrito relationshipsbetweenboneturnoverandenergymetabolism |