Hyper IgE Syndrome and Renal Cell Carcinoma
Hyper IgE Syndrome (HIES) is an immunodeficiency disorder characterized by increased serum levels of IgE, eczema, and recurrent cutaneous and pulmonary infections. In this report, we present, to our knowledge, the first documented case of renal cell carcinoma (RCC) found in a patient with HIES. The...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2017/7083451 |
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| author | Neel H. Patel Mark Ferretti John L. Phillips |
| author_facet | Neel H. Patel Mark Ferretti John L. Phillips |
| author_sort | Neel H. Patel |
| collection | DOAJ |
| description | Hyper IgE Syndrome (HIES) is an immunodeficiency disorder characterized by increased serum levels of IgE, eczema, and recurrent cutaneous and pulmonary infections. In this report, we present, to our knowledge, the first documented case of renal cell carcinoma (RCC) found in a patient with HIES. The patient received infectious disease clearance prior to obtaining a partial nephrectomy which revealed clear cell histology. Both HIES and RCC have an immunological basis for their pathophysiology and may involve common pathways. Further studies may provide insight into any possible link and clinicians should be mindful of immunocompromised patients who present with risk factors for genitourinary malignancy. |
| format | Article |
| id | doaj-art-3c4e99ba194149b1a13e0132533bcf52 |
| institution | OA Journals |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-3c4e99ba194149b1a13e0132533bcf522025-08-20T02:08:18ZengWileyCase Reports in Urology2090-696X2090-69782017-01-01201710.1155/2017/70834517083451Hyper IgE Syndrome and Renal Cell CarcinomaNeel H. Patel0Mark Ferretti1John L. Phillips2Department of Urology, New York Medical College, Valhalla, NY, USADepartment of Urology, New York Medical College, Valhalla, NY, USADepartment of Urology, New York Medical College, Valhalla, NY, USAHyper IgE Syndrome (HIES) is an immunodeficiency disorder characterized by increased serum levels of IgE, eczema, and recurrent cutaneous and pulmonary infections. In this report, we present, to our knowledge, the first documented case of renal cell carcinoma (RCC) found in a patient with HIES. The patient received infectious disease clearance prior to obtaining a partial nephrectomy which revealed clear cell histology. Both HIES and RCC have an immunological basis for their pathophysiology and may involve common pathways. Further studies may provide insight into any possible link and clinicians should be mindful of immunocompromised patients who present with risk factors for genitourinary malignancy.http://dx.doi.org/10.1155/2017/7083451 |
| spellingShingle | Neel H. Patel Mark Ferretti John L. Phillips Hyper IgE Syndrome and Renal Cell Carcinoma Case Reports in Urology |
| title | Hyper IgE Syndrome and Renal Cell Carcinoma |
| title_full | Hyper IgE Syndrome and Renal Cell Carcinoma |
| title_fullStr | Hyper IgE Syndrome and Renal Cell Carcinoma |
| title_full_unstemmed | Hyper IgE Syndrome and Renal Cell Carcinoma |
| title_short | Hyper IgE Syndrome and Renal Cell Carcinoma |
| title_sort | hyper ige syndrome and renal cell carcinoma |
| url | http://dx.doi.org/10.1155/2017/7083451 |
| work_keys_str_mv | AT neelhpatel hyperigesyndromeandrenalcellcarcinoma AT markferretti hyperigesyndromeandrenalcellcarcinoma AT johnlphillips hyperigesyndromeandrenalcellcarcinoma |