A rare case of gliosarcoma: Comprehensive radiological, histopathological, and clinical insights into diagnosis and management
Gliosarcoma is a rare and aggressive variant of glioblastoma, characterized by a biphasic histological pattern consisting of both glial and mesenchymal components. This case report describes the clinical presentation, radiological findings, surgical management, and histopathological analysis of glio...
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Elsevier
2025-06-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043325001517 |
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| author | Paritosh Bhangale, MBBS Shivali Kashikar, MD Pratapsingh Hanuman Parihar, MD Ravishankar Patil, MD Viraj Gupta, MBBS Dhananjay Shinde, MBBS Devyansh Nimodia, MBBS |
| author_facet | Paritosh Bhangale, MBBS Shivali Kashikar, MD Pratapsingh Hanuman Parihar, MD Ravishankar Patil, MD Viraj Gupta, MBBS Dhananjay Shinde, MBBS Devyansh Nimodia, MBBS |
| author_sort | Paritosh Bhangale, MBBS |
| collection | DOAJ |
| description | Gliosarcoma is a rare and aggressive variant of glioblastoma, characterized by a biphasic histological pattern consisting of both glial and mesenchymal components. This case report describes the clinical presentation, radiological findings, surgical management, and histopathological analysis of gliosarcoma in a 30-year-old female. The patient presented with a 10-day history of right-sided headache and recurrent vomiting. Neurological examination was unremarkable, and vital signs were stable. Magnetic resonance imaging (MRI) revealed a heterogeneously enhancing mass lesion involving the right parietal region and the splenium of the corpus callosum, crossing the midline and causing significant ventricular effacement. Imaging features included heterogeneously hypointense signals on T1-weighted imaging, hyperintense signals on T2/FLAIR, areas of blooming on susceptibility-weighted imaging, and restricted diffusion on diffusion-weighted imaging, suggestive of a high-grade glial tumor. The patient underwent surgical resection, and histopathological examination confirmed gliosarcoma. The tumor exhibited a biphasic pattern comprising glial and sarcomatous elements. This case emphasizes the diagnostic challenges associated with gliosarcoma, where radiological features often mimic glioblastoma, necessitating histopathological confirmation. Gliosarcoma's aggressive nature poses significant therapeutic challenges, with treatment strategies involving surgical resection followed by adjuvant radiotherapy and chemotherapy. This report highlights the importance of integrating clinical, radiological, and histopathological findings to achieve an accurate diagnosis and optimize treatment outcomes. It underscores the need for early recognition and a multidisciplinary approach to managing rare central nervous system tumors like gliosarcoma. Further research into advanced therapeutic strategies is warranted to improve the prognosis for such patients. |
| format | Article |
| id | doaj-art-3c4c0205e829463a8ac6bbb8dd1b13c8 |
| institution | DOAJ |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-3c4c0205e829463a8ac6bbb8dd1b13c82025-08-20T03:09:00ZengElsevierRadiology Case Reports1930-04332025-06-012062676268110.1016/j.radcr.2025.02.048A rare case of gliosarcoma: Comprehensive radiological, histopathological, and clinical insights into diagnosis and managementParitosh Bhangale, MBBS0Shivali Kashikar, MD1Pratapsingh Hanuman Parihar, MD2Ravishankar Patil, MD3Viraj Gupta, MBBS4Dhananjay Shinde, MBBS5Devyansh Nimodia, MBBS6Corresponding author.; Department of Radiodiagnosis, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India, 442001Department of Radiodiagnosis, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India, 442001Department of Radiodiagnosis, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India, 442001Department of Radiodiagnosis, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India, 442001Department of Radiodiagnosis, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India, 442001Department of Radiodiagnosis, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India, 442001Department of Radiodiagnosis, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India, 442001Gliosarcoma is a rare and aggressive variant of glioblastoma, characterized by a biphasic histological pattern consisting of both glial and mesenchymal components. This case report describes the clinical presentation, radiological findings, surgical management, and histopathological analysis of gliosarcoma in a 30-year-old female. The patient presented with a 10-day history of right-sided headache and recurrent vomiting. Neurological examination was unremarkable, and vital signs were stable. Magnetic resonance imaging (MRI) revealed a heterogeneously enhancing mass lesion involving the right parietal region and the splenium of the corpus callosum, crossing the midline and causing significant ventricular effacement. Imaging features included heterogeneously hypointense signals on T1-weighted imaging, hyperintense signals on T2/FLAIR, areas of blooming on susceptibility-weighted imaging, and restricted diffusion on diffusion-weighted imaging, suggestive of a high-grade glial tumor. The patient underwent surgical resection, and histopathological examination confirmed gliosarcoma. The tumor exhibited a biphasic pattern comprising glial and sarcomatous elements. This case emphasizes the diagnostic challenges associated with gliosarcoma, where radiological features often mimic glioblastoma, necessitating histopathological confirmation. Gliosarcoma's aggressive nature poses significant therapeutic challenges, with treatment strategies involving surgical resection followed by adjuvant radiotherapy and chemotherapy. This report highlights the importance of integrating clinical, radiological, and histopathological findings to achieve an accurate diagnosis and optimize treatment outcomes. It underscores the need for early recognition and a multidisciplinary approach to managing rare central nervous system tumors like gliosarcoma. Further research into advanced therapeutic strategies is warranted to improve the prognosis for such patients.http://www.sciencedirect.com/science/article/pii/S1930043325001517GliosarcomaGlioblastomaBiphasic tumorRadiological imagingHistopathologyBrain tumor management |
| spellingShingle | Paritosh Bhangale, MBBS Shivali Kashikar, MD Pratapsingh Hanuman Parihar, MD Ravishankar Patil, MD Viraj Gupta, MBBS Dhananjay Shinde, MBBS Devyansh Nimodia, MBBS A rare case of gliosarcoma: Comprehensive radiological, histopathological, and clinical insights into diagnosis and management Radiology Case Reports Gliosarcoma Glioblastoma Biphasic tumor Radiological imaging Histopathology Brain tumor management |
| title | A rare case of gliosarcoma: Comprehensive radiological, histopathological, and clinical insights into diagnosis and management |
| title_full | A rare case of gliosarcoma: Comprehensive radiological, histopathological, and clinical insights into diagnosis and management |
| title_fullStr | A rare case of gliosarcoma: Comprehensive radiological, histopathological, and clinical insights into diagnosis and management |
| title_full_unstemmed | A rare case of gliosarcoma: Comprehensive radiological, histopathological, and clinical insights into diagnosis and management |
| title_short | A rare case of gliosarcoma: Comprehensive radiological, histopathological, and clinical insights into diagnosis and management |
| title_sort | rare case of gliosarcoma comprehensive radiological histopathological and clinical insights into diagnosis and management |
| topic | Gliosarcoma Glioblastoma Biphasic tumor Radiological imaging Histopathology Brain tumor management |
| url | http://www.sciencedirect.com/science/article/pii/S1930043325001517 |
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