A potential strategy to rebuild the tumor immune microenvironment: PANoptosis
The convergence and interplay of pyroptosis, apoptosis, and necroptosis have led to the conceptualization of PANoptosis, an innovative paradigm of inflammatory programmed cell death. Characterized by the hierarchical assembly and activation of the PANoptosome, PANoptosis operates through tightly orc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1626411/full |
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| author | Siyu Wu Boyan Tian Xueying Pang Bowen Sui |
| author_facet | Siyu Wu Boyan Tian Xueying Pang Bowen Sui |
| author_sort | Siyu Wu |
| collection | DOAJ |
| description | The convergence and interplay of pyroptosis, apoptosis, and necroptosis have led to the conceptualization of PANoptosis, an innovative paradigm of inflammatory programmed cell death. Characterized by the hierarchical assembly and activation of the PANoptosome, PANoptosis operates through tightly orchestrated signaling hubs and is intricately linked to organelle functionality. Accumulating evidence underscores its pivotal role in diverse oncogenic processes, positioning PANoptosis as a compelling frontier for antitumor therapeutic exploration. This review delineates the mechanistic underpinnings of PANoptosis, synthesizes its established contributions to tumor progression, and examines its dynamic crosstalk with the tumor immune microenvironment (TIME). Notably, we highlight recent breakthroughs in PANoptosis-driven immunotherapeutic strategies. We further propose that targeting PANoptosis to reprogram TIME represents a transformative approach in oncology, shifting the research paradigm from unimodal cell death regulation to multidimensional intervention. This perspective not only advances fundamental understanding but also holds significant promise for clinical translation, heralding a new era in cancer therapeutics. |
| format | Article |
| id | doaj-art-3c4881822efb49c58e9ae32bf6bc3f23 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-3c4881822efb49c58e9ae32bf6bc3f232025-08-20T04:00:03ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-08-011610.3389/fimmu.2025.16264111626411A potential strategy to rebuild the tumor immune microenvironment: PANoptosisSiyu Wu0Boyan Tian1Xueying Pang2Bowen Sui3Heilongjiang University of Chinese Medicine, Harbin, ChinaHeilongjiang University of Chinese Medicine, Harbin, ChinaFirst Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, ChinaFirst Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, ChinaThe convergence and interplay of pyroptosis, apoptosis, and necroptosis have led to the conceptualization of PANoptosis, an innovative paradigm of inflammatory programmed cell death. Characterized by the hierarchical assembly and activation of the PANoptosome, PANoptosis operates through tightly orchestrated signaling hubs and is intricately linked to organelle functionality. Accumulating evidence underscores its pivotal role in diverse oncogenic processes, positioning PANoptosis as a compelling frontier for antitumor therapeutic exploration. This review delineates the mechanistic underpinnings of PANoptosis, synthesizes its established contributions to tumor progression, and examines its dynamic crosstalk with the tumor immune microenvironment (TIME). Notably, we highlight recent breakthroughs in PANoptosis-driven immunotherapeutic strategies. We further propose that targeting PANoptosis to reprogram TIME represents a transformative approach in oncology, shifting the research paradigm from unimodal cell death regulation to multidimensional intervention. This perspective not only advances fundamental understanding but also holds significant promise for clinical translation, heralding a new era in cancer therapeutics.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1626411/fullPANoptosiscell deathtumor immune microenvironmentimmunotherapyoncogenic process |
| spellingShingle | Siyu Wu Boyan Tian Xueying Pang Bowen Sui A potential strategy to rebuild the tumor immune microenvironment: PANoptosis Frontiers in Immunology PANoptosis cell death tumor immune microenvironment immunotherapy oncogenic process |
| title | A potential strategy to rebuild the tumor immune microenvironment: PANoptosis |
| title_full | A potential strategy to rebuild the tumor immune microenvironment: PANoptosis |
| title_fullStr | A potential strategy to rebuild the tumor immune microenvironment: PANoptosis |
| title_full_unstemmed | A potential strategy to rebuild the tumor immune microenvironment: PANoptosis |
| title_short | A potential strategy to rebuild the tumor immune microenvironment: PANoptosis |
| title_sort | potential strategy to rebuild the tumor immune microenvironment panoptosis |
| topic | PANoptosis cell death tumor immune microenvironment immunotherapy oncogenic process |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1626411/full |
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