Can Dexrazoxane and Carvedilol prevent Doxorubicin-induced nephrotoxicity?
Doxorubicin (DOX) is a cytostatic drug with a broad spectrum of anticancer activity that has been used in oncology for over 50 years. Among many adverse effects in humans, the most dangerous is late dilated cardiomyopathy, which appears even years after completion of therapy. However, in cats, the c...
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Sciendo
2024-12-01
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| Series: | Current Issues in Pharmacy and Medical Sciences |
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| Online Access: | https://doi.org/10.2478/cipms-2024-0038 |
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| author | Szponar Jaroslaw Gorska Agnieszka Ostrowska-Lesko Marta Wielgomas Bartosz Mandziuk Slawomir |
| author_facet | Szponar Jaroslaw Gorska Agnieszka Ostrowska-Lesko Marta Wielgomas Bartosz Mandziuk Slawomir |
| author_sort | Szponar Jaroslaw |
| collection | DOAJ |
| description | Doxorubicin (DOX) is a cytostatic drug with a broad spectrum of anticancer activity that has been used in oncology for over 50 years. Among many adverse effects in humans, the most dangerous is late dilated cardiomyopathy, which appears even years after completion of therapy. However, in cats, the critical organ for the toxic effects of DOX is the kidney. Herein, nephrotoxicity is manifested as azotemia. The main aim of our study was to evaluate the protective effect of dexrazoxane (DEX) and carvedilol (CVD) against the nephrotoxic effects of DOX. Nephrotoxicity studies were performed in a rat model of repeated DOX administration. Analyzed blood morphological, biochemical and histopathological findings revealed that DEX has a dual effect: it positively impacts DOX-induced histological alterations and creatinine levels while negatively affecting urea concentration. Thus, the results do not support univocally recommend DEX to prevent nephrotoxicity caused by DOX in cats. However, further studies using initially lower doses of DEX are needed to assess the prevention of nephrotoxicity in cats clinically treated with DOX. |
| format | Article |
| id | doaj-art-3c44bcba2a2f4b108ef357936d4f93d2 |
| institution | OA Journals |
| issn | 2300-6676 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Current Issues in Pharmacy and Medical Sciences |
| spelling | doaj-art-3c44bcba2a2f4b108ef357936d4f93d22025-08-20T02:18:09ZengSciendoCurrent Issues in Pharmacy and Medical Sciences2300-66762024-12-0137423223910.2478/cipms-2024-0038Can Dexrazoxane and Carvedilol prevent Doxorubicin-induced nephrotoxicity?Szponar Jaroslaw0Gorska Agnieszka1Ostrowska-Lesko Marta2Wielgomas Bartosz3Mandziuk Slawomir4Toxicology Clinic, Faculty of Medicine, Medical University of Lublin, PolandToxicology Clinic, Faculty of Medicine, Medical University of Lublin, PolandChair and Department of Toxicology, Medical University of Lublin, PolandDepartment of Toxicology, Medical University of Gdansk, PolandDepartment of Pneumology, Oncology and Allergology, Medical University of Lublin, PolandDoxorubicin (DOX) is a cytostatic drug with a broad spectrum of anticancer activity that has been used in oncology for over 50 years. Among many adverse effects in humans, the most dangerous is late dilated cardiomyopathy, which appears even years after completion of therapy. However, in cats, the critical organ for the toxic effects of DOX is the kidney. Herein, nephrotoxicity is manifested as azotemia. The main aim of our study was to evaluate the protective effect of dexrazoxane (DEX) and carvedilol (CVD) against the nephrotoxic effects of DOX. Nephrotoxicity studies were performed in a rat model of repeated DOX administration. Analyzed blood morphological, biochemical and histopathological findings revealed that DEX has a dual effect: it positively impacts DOX-induced histological alterations and creatinine levels while negatively affecting urea concentration. Thus, the results do not support univocally recommend DEX to prevent nephrotoxicity caused by DOX in cats. However, further studies using initially lower doses of DEX are needed to assess the prevention of nephrotoxicity in cats clinically treated with DOX.https://doi.org/10.2478/cipms-2024-0038post-anthracycline nephrotoxicitynephroprotectiondexrazoxanecarvediloldoxorubicin |
| spellingShingle | Szponar Jaroslaw Gorska Agnieszka Ostrowska-Lesko Marta Wielgomas Bartosz Mandziuk Slawomir Can Dexrazoxane and Carvedilol prevent Doxorubicin-induced nephrotoxicity? Current Issues in Pharmacy and Medical Sciences post-anthracycline nephrotoxicity nephroprotection dexrazoxane carvedilol doxorubicin |
| title | Can Dexrazoxane and Carvedilol prevent Doxorubicin-induced nephrotoxicity? |
| title_full | Can Dexrazoxane and Carvedilol prevent Doxorubicin-induced nephrotoxicity? |
| title_fullStr | Can Dexrazoxane and Carvedilol prevent Doxorubicin-induced nephrotoxicity? |
| title_full_unstemmed | Can Dexrazoxane and Carvedilol prevent Doxorubicin-induced nephrotoxicity? |
| title_short | Can Dexrazoxane and Carvedilol prevent Doxorubicin-induced nephrotoxicity? |
| title_sort | can dexrazoxane and carvedilol prevent doxorubicin induced nephrotoxicity |
| topic | post-anthracycline nephrotoxicity nephroprotection dexrazoxane carvedilol doxorubicin |
| url | https://doi.org/10.2478/cipms-2024-0038 |
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