The novel functions of chemokines in lung cancer progression
Chemokines are key molecules that regulate immune cell migration and play critical roles in the tumor microenvironment. In lung cancer, chemokine dysregulation is closely linked to tumor progression. They promote immune cell infiltration and interact with tumor cells, enhancing tumor invasiveness an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607225/full |
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| _version_ | 1849422586003324928 |
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| author | Xiaorui Gong Xueying Wang Jing Jin Zhiqiang Gong |
| author_facet | Xiaorui Gong Xueying Wang Jing Jin Zhiqiang Gong |
| author_sort | Xiaorui Gong |
| collection | DOAJ |
| description | Chemokines are key molecules that regulate immune cell migration and play critical roles in the tumor microenvironment. In lung cancer, chemokine dysregulation is closely linked to tumor progression. They promote immune cell infiltration and interact with tumor cells, enhancing tumor invasiveness and metastatic potential. This review highlights chemokine-mediated mechanisms, focusing on CCR9/CCL25 and CXCL12/CXCR4 axes, which promote tumor growth, metastasis, and immune evasion via PI3K/AKT and MAPK signaling. Elevated expression of these pathways correlates with poor outcomes and aggressive phenotypes. In SCLC, CXCR4 inhibitors show therapeutic promise when combined with chemotherapy or immunotherapy. This review summarizes the prognostic and therapeutic relevance of chemokines in lung cancer progression. |
| format | Article |
| id | doaj-art-3c42986adf03458dbae19a3da35ba5ad |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-3c42986adf03458dbae19a3da35ba5ad2025-08-20T03:31:01ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.16072251607225The novel functions of chemokines in lung cancer progressionXiaorui Gong0Xueying Wang1Jing Jin2Zhiqiang Gong3Medical Oncology Department of Thoracic Cancer (II), Cancer Hospital of China Medical University Liaoning Cancer Hospital and Institute, Cancer Hospital of Dalian University of Technology, Shenyang, ChinaMedical Oncology Department of Thoracic Cancer (II), Cancer Hospital of China Medical University Liaoning Cancer Hospital and Institute, Cancer Hospital of Dalian University of Technology, Shenyang, ChinaDepartment of Child Healthcare, Shenyang Children’s Hospital, Shenyang, ChinaAbdominal Radiotherapy Ward II, Cancer Hospital of China Medical University Liaoning Cancer Hospital and Institute, Cancer Hospital of Dalian University of Technology, Shenyang, ChinaChemokines are key molecules that regulate immune cell migration and play critical roles in the tumor microenvironment. In lung cancer, chemokine dysregulation is closely linked to tumor progression. They promote immune cell infiltration and interact with tumor cells, enhancing tumor invasiveness and metastatic potential. This review highlights chemokine-mediated mechanisms, focusing on CCR9/CCL25 and CXCL12/CXCR4 axes, which promote tumor growth, metastasis, and immune evasion via PI3K/AKT and MAPK signaling. Elevated expression of these pathways correlates with poor outcomes and aggressive phenotypes. In SCLC, CXCR4 inhibitors show therapeutic promise when combined with chemotherapy or immunotherapy. This review summarizes the prognostic and therapeutic relevance of chemokines in lung cancer progression.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607225/fullchemokineslung cancerimmunotherapyCCR9CXCL12PI3K pathway |
| spellingShingle | Xiaorui Gong Xueying Wang Jing Jin Zhiqiang Gong The novel functions of chemokines in lung cancer progression Frontiers in Immunology chemokines lung cancer immunotherapy CCR9 CXCL12 PI3K pathway |
| title | The novel functions of chemokines in lung cancer progression |
| title_full | The novel functions of chemokines in lung cancer progression |
| title_fullStr | The novel functions of chemokines in lung cancer progression |
| title_full_unstemmed | The novel functions of chemokines in lung cancer progression |
| title_short | The novel functions of chemokines in lung cancer progression |
| title_sort | novel functions of chemokines in lung cancer progression |
| topic | chemokines lung cancer immunotherapy CCR9 CXCL12 PI3K pathway |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607225/full |
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