Clinicopathological, Histopathological, and Immunohistochemical Analysis of Mandibular Fibrosarcoma in a DSH Cat: A Case Report
ABSTRACT A 4‐year‐old white male DSH cat was presented to the Veterinary Hospital on 18 December 2023, with a history of lethargy, loss of appetite, and salivation. During the inspection of the oral cavity, unilateral swelling was observed on the ventral side of the jaw. Before any therapeutic inter...
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Wiley
2024-11-01
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| Series: | Veterinary Medicine and Science |
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| Online Access: | https://doi.org/10.1002/vms3.70099 |
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| author | Mahmood Ahmadi‐hamedani Hamid Reza Moslemi Sahar Ghaffari Khaligh Mehdi Sedghi Kimia Sattari |
| author_facet | Mahmood Ahmadi‐hamedani Hamid Reza Moslemi Sahar Ghaffari Khaligh Mehdi Sedghi Kimia Sattari |
| author_sort | Mahmood Ahmadi‐hamedani |
| collection | DOAJ |
| description | ABSTRACT A 4‐year‐old white male DSH cat was presented to the Veterinary Hospital on 18 December 2023, with a history of lethargy, loss of appetite, and salivation. During the inspection of the oral cavity, unilateral swelling was observed on the ventral side of the jaw. Before any therapeutic intervention, a cell blood count (CBC) test and FNA cytology were conducted. A five‐day course of adjunctive treatment, including ceftriaxone (5.5 mg/kg via IV) and clindamycin (25 mg/kg via IV), was given due to a suspicion of infection. Pantoprazole, metoclopramide (administered at 1 mg/kg via IV and IM), and duphalyte 500 mL (10 mL/kg IV) were used concurrently to alleviate nausea and stimulate appetite. Following a lack of improvement, a radical excision procedure was performed on tooth number 304 after the 5‐day treatment to excise the mass for histopathology and immunohistochemical analysis. The observation of mitotic bodies, pleomorphism, necrosis, and haemorrhage were consistent with malignancy, and squamous cell carcinoma (SCC) was suspected. Immunohistochemical staining was positive for the vimentin marker, the S‐100 protein, and desmin. This report describes a rare case of oral fibrosarcoma in a DSH cat in Iran. |
| format | Article |
| id | doaj-art-3c425a03a29b4cc19e4b1f5b36da0849 |
| institution | Kabale University |
| issn | 2053-1095 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
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| series | Veterinary Medicine and Science |
| spelling | doaj-art-3c425a03a29b4cc19e4b1f5b36da08492025-01-20T17:16:45ZengWileyVeterinary Medicine and Science2053-10952024-11-01106n/an/a10.1002/vms3.70099Clinicopathological, Histopathological, and Immunohistochemical Analysis of Mandibular Fibrosarcoma in a DSH Cat: A Case ReportMahmood Ahmadi‐hamedani0Hamid Reza Moslemi1Sahar Ghaffari Khaligh2Mehdi Sedghi3Kimia Sattari4Department of Clinical Sciences Faculty of Veterinary Medicine Semnan University Semnan IranDepartment of Clinical Sciences Faculty of Veterinary Medicine Semnan University Semnan IranDepartment of Pathobiological science Faculty of Veterinary Medicine Semnan University Semnan IranDepartment of Small Animal Disease with Clinic Private Veterinary Clinic Semnan IranDepartment of Clinical Sciences Faculty of Veterinary Medicine Semnan University Semnan IranABSTRACT A 4‐year‐old white male DSH cat was presented to the Veterinary Hospital on 18 December 2023, with a history of lethargy, loss of appetite, and salivation. During the inspection of the oral cavity, unilateral swelling was observed on the ventral side of the jaw. Before any therapeutic intervention, a cell blood count (CBC) test and FNA cytology were conducted. A five‐day course of adjunctive treatment, including ceftriaxone (5.5 mg/kg via IV) and clindamycin (25 mg/kg via IV), was given due to a suspicion of infection. Pantoprazole, metoclopramide (administered at 1 mg/kg via IV and IM), and duphalyte 500 mL (10 mL/kg IV) were used concurrently to alleviate nausea and stimulate appetite. Following a lack of improvement, a radical excision procedure was performed on tooth number 304 after the 5‐day treatment to excise the mass for histopathology and immunohistochemical analysis. The observation of mitotic bodies, pleomorphism, necrosis, and haemorrhage were consistent with malignancy, and squamous cell carcinoma (SCC) was suspected. Immunohistochemical staining was positive for the vimentin marker, the S‐100 protein, and desmin. This report describes a rare case of oral fibrosarcoma in a DSH cat in Iran.https://doi.org/10.1002/vms3.70099clinicopathologyDSH catfibrosarcomaimmunohistochemistry |
| spellingShingle | Mahmood Ahmadi‐hamedani Hamid Reza Moslemi Sahar Ghaffari Khaligh Mehdi Sedghi Kimia Sattari Clinicopathological, Histopathological, and Immunohistochemical Analysis of Mandibular Fibrosarcoma in a DSH Cat: A Case Report Veterinary Medicine and Science clinicopathology DSH cat fibrosarcoma immunohistochemistry |
| title | Clinicopathological, Histopathological, and Immunohistochemical Analysis of Mandibular Fibrosarcoma in a DSH Cat: A Case Report |
| title_full | Clinicopathological, Histopathological, and Immunohistochemical Analysis of Mandibular Fibrosarcoma in a DSH Cat: A Case Report |
| title_fullStr | Clinicopathological, Histopathological, and Immunohistochemical Analysis of Mandibular Fibrosarcoma in a DSH Cat: A Case Report |
| title_full_unstemmed | Clinicopathological, Histopathological, and Immunohistochemical Analysis of Mandibular Fibrosarcoma in a DSH Cat: A Case Report |
| title_short | Clinicopathological, Histopathological, and Immunohistochemical Analysis of Mandibular Fibrosarcoma in a DSH Cat: A Case Report |
| title_sort | clinicopathological histopathological and immunohistochemical analysis of mandibular fibrosarcoma in a dsh cat a case report |
| topic | clinicopathology DSH cat fibrosarcoma immunohistochemistry |
| url | https://doi.org/10.1002/vms3.70099 |
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