Comparative Analysis of Vertical Transmission of SARS-CoV-2 Antibodies in Vaccinated and Non-Vaccinated Pregnant Women
Pregnancy is a risk factor for developing a severe, complicated form of COVID-19. Medical reports have revealed that pregnancy increases three times the risk of ICU admission and 1.7 times the risk of death in patients with COVID-19. The crossing of the placenta by the antibodies generated through v...
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Bucharest College of Physicians
2021-04-01
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| Series: | Modern Medicine |
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| Online Access: | https://medicinamoderna.ro/wp-content/uploads/2021/12/Comparative-Analysis-of-Vertical-Transmission-of-SARS-CoV-2-Antibodies-in-Vaccinated-and-Non-Vaccinated-Pregnant-Women-9.pdf |
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| author | Madalina IORDACHE Diana SECARA Claudia MEHEDINTU Marina ANTONOVICI Natalia TURCAN Monica Mihaela CIRSTOIU |
| author_facet | Madalina IORDACHE Diana SECARA Claudia MEHEDINTU Marina ANTONOVICI Natalia TURCAN Monica Mihaela CIRSTOIU |
| author_sort | Madalina IORDACHE |
| collection | DOAJ |
| description | Pregnancy is a risk factor for developing a severe, complicated form of COVID-19. Medical reports have revealed that pregnancy increases three times the risk of ICU admission and 1.7 times the risk of death in patients with COVID-19. The crossing of the placenta by the antibodies generated through vaccination offer a level of protection that should not be ignored. We aimed to comparatively analyze the levels of SARS-CoV-2 IgG and IgM antibodies in pregnant women who have had this infection during pregnancy or have undergone a complete vaccination cycle during pregnancy, as well as antibody levels in newborns. The inclusion criterion was history of SARS-CoV-2 infection during pregnancy or COVID-19 complete vaccination. For each case the peri-partum values of IgG and IgM SARSCoV- 2 antibodies were analyzed in the same laboratory along with those of their newborns. The vaccination rate in our study group was about 6%. All cases had a significant value of protective IgG SARS-CoV-2 antibodies and the level of protective antibodies of the newborns closely followed maternal values. From the cases with SARS-CoV-2 infection during pregnancy, only 16.6% had a protective level of antibodies and 75% of the newborns from these cases had protective levels of IgG SARS-CoV-2 antibodies. Our results clearly plead in favor of vaccination in pregnancy which provides significant benefits for both mothers and infants. |
| format | Article |
| id | doaj-art-3c423f2262074fcf9c117fe76e50f530 |
| institution | OA Journals |
| issn | 1223-0472 2360-2473 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | Bucharest College of Physicians |
| record_format | Article |
| series | Modern Medicine |
| spelling | doaj-art-3c423f2262074fcf9c117fe76e50f5302025-08-20T02:15:36ZengBucharest College of PhysiciansModern Medicine1223-04722360-24732021-04-01284419423https://doi.org/10.31689/rmm.2021.28.4.419Comparative Analysis of Vertical Transmission of SARS-CoV-2 Antibodies in Vaccinated and Non-Vaccinated Pregnant WomenMadalina IORDACHE0Diana SECARA1Claudia MEHEDINTU2https://orcid.org/0000-0001-5231-2848Marina ANTONOVICI3Natalia TURCAN4https://orcid.org/0000-0003-1994-3570Monica Mihaela CIRSTOIU5https://orcid.org/0000-0002-4063-5057Department of Obstetrics and Gynecology, „Carol Davila” University of Medicine and Pharmacy, Emergency University Hospital, Bucharest, RomaniaDepartment of Obstetrics and Gynecology, „Carol Davila” University of Medicine and Pharmacy, Emergency University Hospital, Bucharest, Romania„Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania„Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaDepartment of Obstetrics and Gynecology, Emergency University Hospital, Bucharest, Romania„Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaPregnancy is a risk factor for developing a severe, complicated form of COVID-19. Medical reports have revealed that pregnancy increases three times the risk of ICU admission and 1.7 times the risk of death in patients with COVID-19. The crossing of the placenta by the antibodies generated through vaccination offer a level of protection that should not be ignored. We aimed to comparatively analyze the levels of SARS-CoV-2 IgG and IgM antibodies in pregnant women who have had this infection during pregnancy or have undergone a complete vaccination cycle during pregnancy, as well as antibody levels in newborns. The inclusion criterion was history of SARS-CoV-2 infection during pregnancy or COVID-19 complete vaccination. For each case the peri-partum values of IgG and IgM SARSCoV- 2 antibodies were analyzed in the same laboratory along with those of their newborns. The vaccination rate in our study group was about 6%. All cases had a significant value of protective IgG SARS-CoV-2 antibodies and the level of protective antibodies of the newborns closely followed maternal values. From the cases with SARS-CoV-2 infection during pregnancy, only 16.6% had a protective level of antibodies and 75% of the newborns from these cases had protective levels of IgG SARS-CoV-2 antibodies. Our results clearly plead in favor of vaccination in pregnancy which provides significant benefits for both mothers and infants.https://medicinamoderna.ro/wp-content/uploads/2021/12/Comparative-Analysis-of-Vertical-Transmission-of-SARS-CoV-2-Antibodies-in-Vaccinated-and-Non-Vaccinated-Pregnant-Women-9.pdfsars-cov-2covid-19vaccinationpregnancy |
| spellingShingle | Madalina IORDACHE Diana SECARA Claudia MEHEDINTU Marina ANTONOVICI Natalia TURCAN Monica Mihaela CIRSTOIU Comparative Analysis of Vertical Transmission of SARS-CoV-2 Antibodies in Vaccinated and Non-Vaccinated Pregnant Women Modern Medicine sars-cov-2 covid-19 vaccination pregnancy |
| title | Comparative Analysis of Vertical Transmission of SARS-CoV-2 Antibodies in Vaccinated and Non-Vaccinated Pregnant Women |
| title_full | Comparative Analysis of Vertical Transmission of SARS-CoV-2 Antibodies in Vaccinated and Non-Vaccinated Pregnant Women |
| title_fullStr | Comparative Analysis of Vertical Transmission of SARS-CoV-2 Antibodies in Vaccinated and Non-Vaccinated Pregnant Women |
| title_full_unstemmed | Comparative Analysis of Vertical Transmission of SARS-CoV-2 Antibodies in Vaccinated and Non-Vaccinated Pregnant Women |
| title_short | Comparative Analysis of Vertical Transmission of SARS-CoV-2 Antibodies in Vaccinated and Non-Vaccinated Pregnant Women |
| title_sort | comparative analysis of vertical transmission of sars cov 2 antibodies in vaccinated and non vaccinated pregnant women |
| topic | sars-cov-2 covid-19 vaccination pregnancy |
| url | https://medicinamoderna.ro/wp-content/uploads/2021/12/Comparative-Analysis-of-Vertical-Transmission-of-SARS-CoV-2-Antibodies-in-Vaccinated-and-Non-Vaccinated-Pregnant-Women-9.pdf |
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