Dietary inflammatory index mediation lifestyle patterns and depression among women with osteopenia or osteoporosis
ObjectiveLifestyle factors play a critical role in osteoporosis management and are closely linked to the development and progression of comorbid depression. This study examines lifestyle patterns and their association with depression in individuals with osteopenia or osteoporosis, while assessing th...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1578954/full |
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| author | Baoping Wang Yuxin Fan Shaofang Tang Weihong Guo Yin Li Chenlin Dai |
| author_facet | Baoping Wang Yuxin Fan Shaofang Tang Weihong Guo Yin Li Chenlin Dai |
| author_sort | Baoping Wang |
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| description | ObjectiveLifestyle factors play a critical role in osteoporosis management and are closely linked to the development and progression of comorbid depression. This study examines lifestyle patterns and their association with depression in individuals with osteopenia or osteoporosis, while assessing the mediating role of the Dietary Inflammatory Index (DII).MethodsData from the National Health and Nutrition Examination Survey (NHANES) 2009–2020 were analyzed using latent class analysis (LCA) to classify 3,384 adults based on their lifestyle behaviors. A generalized linear model (GLM) evaluated the effects of lifestyle patterns on depression, and mediation analysis tested associations between these patterns, DII, and Patient Health Questionnaire-9 (PHQ-9) scores.ResultsLCA identified three lifestyle groups: healthy but inactive (34.16%), unhealthy (8.78%), and sedentary (57.06%). The unhealthy (OR = 2.848, 95% CI = 1.550–5.234, p = 0.001) and sedentary (OR = 1.600, 95% CI = 1.127–2.271, p = 0.009) groups were associated with higher depression risk in women. DII partially mediated the relationships between unhealthy lifestyle and PHQ-9 (effect coefficient = 0.095, 95% CI: 0.056–0.135) and between sedentary lifestyle and PHQ-9 (effect coefficient = 0.059, 95% CI: 0.017–0.115).ConclusionThese findings suggest that lifestyle patterns significantly influence depression in women with osteopenia or osteoporosis, with DII serving as a partial mediator. |
| format | Article |
| id | doaj-art-3c405aa2e2224635b6c01ee12a410e87 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-3c405aa2e2224635b6c01ee12a410e872025-08-20T03:28:24ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-07-011210.3389/fnut.2025.15789541578954Dietary inflammatory index mediation lifestyle patterns and depression among women with osteopenia or osteoporosisBaoping Wang0Yuxin Fan1Shaofang Tang2Weihong Guo3Yin Li4Chenlin Dai5Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, ChinaMedical School of Tianjin University, Tianjin University, Tianjin, ChinaDepartment of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, ChinaObjectiveLifestyle factors play a critical role in osteoporosis management and are closely linked to the development and progression of comorbid depression. This study examines lifestyle patterns and their association with depression in individuals with osteopenia or osteoporosis, while assessing the mediating role of the Dietary Inflammatory Index (DII).MethodsData from the National Health and Nutrition Examination Survey (NHANES) 2009–2020 were analyzed using latent class analysis (LCA) to classify 3,384 adults based on their lifestyle behaviors. A generalized linear model (GLM) evaluated the effects of lifestyle patterns on depression, and mediation analysis tested associations between these patterns, DII, and Patient Health Questionnaire-9 (PHQ-9) scores.ResultsLCA identified three lifestyle groups: healthy but inactive (34.16%), unhealthy (8.78%), and sedentary (57.06%). The unhealthy (OR = 2.848, 95% CI = 1.550–5.234, p = 0.001) and sedentary (OR = 1.600, 95% CI = 1.127–2.271, p = 0.009) groups were associated with higher depression risk in women. DII partially mediated the relationships between unhealthy lifestyle and PHQ-9 (effect coefficient = 0.095, 95% CI: 0.056–0.135) and between sedentary lifestyle and PHQ-9 (effect coefficient = 0.059, 95% CI: 0.017–0.115).ConclusionThese findings suggest that lifestyle patterns significantly influence depression in women with osteopenia or osteoporosis, with DII serving as a partial mediator.https://www.frontiersin.org/articles/10.3389/fnut.2025.1578954/fulldietary inflammation indexdepressionlifestyle patternsosteopeniaosteoporosisNHANES |
| spellingShingle | Baoping Wang Yuxin Fan Shaofang Tang Weihong Guo Yin Li Chenlin Dai Dietary inflammatory index mediation lifestyle patterns and depression among women with osteopenia or osteoporosis Frontiers in Nutrition dietary inflammation index depression lifestyle patterns osteopenia osteoporosis NHANES |
| title | Dietary inflammatory index mediation lifestyle patterns and depression among women with osteopenia or osteoporosis |
| title_full | Dietary inflammatory index mediation lifestyle patterns and depression among women with osteopenia or osteoporosis |
| title_fullStr | Dietary inflammatory index mediation lifestyle patterns and depression among women with osteopenia or osteoporosis |
| title_full_unstemmed | Dietary inflammatory index mediation lifestyle patterns and depression among women with osteopenia or osteoporosis |
| title_short | Dietary inflammatory index mediation lifestyle patterns and depression among women with osteopenia or osteoporosis |
| title_sort | dietary inflammatory index mediation lifestyle patterns and depression among women with osteopenia or osteoporosis |
| topic | dietary inflammation index depression lifestyle patterns osteopenia osteoporosis NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1578954/full |
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