Beta-hydroxybutyrate counteracts the deleterious effects of a saturated high-fat diet on synaptic AMPAR receptors and cognitive performance

Beta-hydroxybutyrate counteracts the deleterious effects of a saturated high-fat diet on synaptic AMPAR receptors and cognitive performance

The ketogenic diet —high in fat and low in carbohydrates— and intermittent fasting have gained popularity not only for weight management but also for their potential to delay cognitive decline associated with neurodegenerative diseases and aging. However, adherence to these diets remains low due to...

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Bibliographic Details
Main Authors: Rocío Rojas, Christian Griñán-Ferré, Aida Castellanos, Ernesto Griego, Marc Martínez, Juan de Dios Navarro-López, Lydia Jiménez-Díaz, José Rodríguez-Álvarez, David Soto del Cerro, Pablo E. Castillo, Mercè Pallàs, Núria Casals, Rut Fadó
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Metabolism
Subjects:
Beta-hydroxybutyrate
Palmitic acid
AMPA receptor
Saturated fatty acid-rich diet
Memory
Synaptic plasticity
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825001140
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