Clinical Phenotype of Diabetic Peripheral Neuropathy and Relation to Symptom Patterns: Cluster and Factor Analysis in Patients with Type 2 Diabetes in Korea
Objectives. Patients with diabetic peripheral neuropathy (DPN) is the most common complication. However, patients are usually suffering from not only diverse sensory deficit but also neuropathy-related discomforts. The aim of this study is to identify distinct groups of patients with DPN with respec...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/5751687 |
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| author | Jong Chul Won Yong-Jin Im Ji-Hyun Lee Chong Hwa Kim Hyuk Sang Kwon Bong-Yun Cha Tae Sun Park |
| author_facet | Jong Chul Won Yong-Jin Im Ji-Hyun Lee Chong Hwa Kim Hyuk Sang Kwon Bong-Yun Cha Tae Sun Park |
| author_sort | Jong Chul Won |
| collection | DOAJ |
| description | Objectives. Patients with diabetic peripheral neuropathy (DPN) is the most common complication. However, patients are usually suffering from not only diverse sensory deficit but also neuropathy-related discomforts. The aim of this study is to identify distinct groups of patients with DPN with respect to its clinical impacts on symptom patterns and comorbidities. Methods. A hierarchical cluster analysis and factor analysis were performed to identify relevant subgroups of patients with DPN (n=1338) and symptom patterns. Results. Patients with DPN were divided into three clusters: asymptomatic (cluster 1, n=448, 33.5%), moderate symptoms with disturbed sleep (cluster 2, n=562, 42.0%), and severe symptoms with decreased quality of life (cluster 3, n=328, 24.5%). Patients in cluster 3, compared with clusters 1 and 2, were characterized by higher levels of HbA1c and more severe pain and physical impairments. Patients in cluster 2 had moderate pain levels but disturbed sleep patterns comparable to those in cluster 3. The frequency of symptoms on each item of MNSI by “painful” symptom pattern showed a similar distribution pattern with increasing intensities along the three clusters. Conclusions. Cluster and factor analysis endorsed the use of comprehensive and symptomatic subgrouping to individualize the evaluation of patients with DPN. |
| format | Article |
| id | doaj-art-3c3febbb43274702a44f3e8a2db0a94b |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-3c3febbb43274702a44f3e8a2db0a94b2025-08-20T03:55:37ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/57516875751687Clinical Phenotype of Diabetic Peripheral Neuropathy and Relation to Symptom Patterns: Cluster and Factor Analysis in Patients with Type 2 Diabetes in KoreaJong Chul Won0Yong-Jin Im1Ji-Hyun Lee2Chong Hwa Kim3Hyuk Sang Kwon4Bong-Yun Cha5Tae Sun Park6Department of Internal Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Sanggye Paik Hospital, Inje University School of Medicine, Seoul, Republic of KoreaClinical Trial Center and Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Republic of KoreaDepartment of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Republic of KoreaDepartment of Internal Medicine, Sejong General Hospital, Bucheon, Republic of KoreaDepartment of Internal Medicine, The Catholic University of Korea, School of Medicine, Seoul, Republic of KoreaDepartment of Internal Medicine, The Catholic University of Korea, School of Medicine, Seoul, Republic of KoreaDepartment of Internal Medicine Chonbuk National University Medical School, Research Institute of Clinical Medicine Chonbuk National University Hospital, Division of Endocrinology and Metabolism, Jeonju, Republic of KoreaObjectives. Patients with diabetic peripheral neuropathy (DPN) is the most common complication. However, patients are usually suffering from not only diverse sensory deficit but also neuropathy-related discomforts. The aim of this study is to identify distinct groups of patients with DPN with respect to its clinical impacts on symptom patterns and comorbidities. Methods. A hierarchical cluster analysis and factor analysis were performed to identify relevant subgroups of patients with DPN (n=1338) and symptom patterns. Results. Patients with DPN were divided into three clusters: asymptomatic (cluster 1, n=448, 33.5%), moderate symptoms with disturbed sleep (cluster 2, n=562, 42.0%), and severe symptoms with decreased quality of life (cluster 3, n=328, 24.5%). Patients in cluster 3, compared with clusters 1 and 2, were characterized by higher levels of HbA1c and more severe pain and physical impairments. Patients in cluster 2 had moderate pain levels but disturbed sleep patterns comparable to those in cluster 3. The frequency of symptoms on each item of MNSI by “painful” symptom pattern showed a similar distribution pattern with increasing intensities along the three clusters. Conclusions. Cluster and factor analysis endorsed the use of comprehensive and symptomatic subgrouping to individualize the evaluation of patients with DPN.http://dx.doi.org/10.1155/2017/5751687 |
| spellingShingle | Jong Chul Won Yong-Jin Im Ji-Hyun Lee Chong Hwa Kim Hyuk Sang Kwon Bong-Yun Cha Tae Sun Park Clinical Phenotype of Diabetic Peripheral Neuropathy and Relation to Symptom Patterns: Cluster and Factor Analysis in Patients with Type 2 Diabetes in Korea Journal of Diabetes Research |
| title | Clinical Phenotype of Diabetic Peripheral Neuropathy and Relation to Symptom Patterns: Cluster and Factor Analysis in Patients with Type 2 Diabetes in Korea |
| title_full | Clinical Phenotype of Diabetic Peripheral Neuropathy and Relation to Symptom Patterns: Cluster and Factor Analysis in Patients with Type 2 Diabetes in Korea |
| title_fullStr | Clinical Phenotype of Diabetic Peripheral Neuropathy and Relation to Symptom Patterns: Cluster and Factor Analysis in Patients with Type 2 Diabetes in Korea |
| title_full_unstemmed | Clinical Phenotype of Diabetic Peripheral Neuropathy and Relation to Symptom Patterns: Cluster and Factor Analysis in Patients with Type 2 Diabetes in Korea |
| title_short | Clinical Phenotype of Diabetic Peripheral Neuropathy and Relation to Symptom Patterns: Cluster and Factor Analysis in Patients with Type 2 Diabetes in Korea |
| title_sort | clinical phenotype of diabetic peripheral neuropathy and relation to symptom patterns cluster and factor analysis in patients with type 2 diabetes in korea |
| url | http://dx.doi.org/10.1155/2017/5751687 |
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