Understanding the impact of COVID-19 on quality of life using surveys and Mendelian randomization
Abstract The COVID-19 pandemic has significantly impacted the quality of life (QoL) of individuals in China, affecting both their physical and mental well-being. This study aims to comprehensively analyze the factors influencing QoL in China during the pandemic. In 2022, we collected data using a se...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-81579-5 |
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| _version_ | 1850103251269058560 |
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| author | Kexin Jiang Hua Ji Lihong Ma Zhirong Zhao Yiwen Zhao Jiajie Feng Zheng Tang Ruiwu Dai |
| author_facet | Kexin Jiang Hua Ji Lihong Ma Zhirong Zhao Yiwen Zhao Jiajie Feng Zheng Tang Ruiwu Dai |
| author_sort | Kexin Jiang |
| collection | DOAJ |
| description | Abstract The COVID-19 pandemic has significantly impacted the quality of life (QoL) of individuals in China, affecting both their physical and mental well-being. This study aims to comprehensively analyze the factors influencing QoL in China during the pandemic. In 2022, we collected data using a self-developed questionnaire (dataset 2) and obtained dataset 1 from the 2021 China General Social Survey (CGSS). After confirming the scale’s reliability and validity, we employed a random forest algorithm to prioritize the factors. Subsequently, Mendelian randomization analyses were conducted using data from the MRC IEU OpenGWAS data infrastructure. By comparing data from two periods with low and high infection rates, the results showed that among the various influences brought about by the prevalence of COVID-19, sleep disorders have a significant and widespread impact on the quality of life, especially for the elderly. Through the inclusion of Mendelian randomization analysis, we found that COVID-19 have a relative increase in the risk of developing insomnia by approximately 26.7% (OR = 1.267). These findings can inform the development of targeted interventions and strategies to improve overall well-being. |
| format | Article |
| id | doaj-art-3c3d58b41f124b828d6167bf9c758cea |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-3c3d58b41f124b828d6167bf9c758cea2025-08-20T02:39:35ZengNature PortfolioScientific Reports2045-23222024-12-0114111110.1038/s41598-024-81579-5Understanding the impact of COVID-19 on quality of life using surveys and Mendelian randomizationKexin Jiang0Hua Ji1Lihong Ma2Zhirong Zhao3Yiwen Zhao4Jiajie Feng5Zheng Tang6Ruiwu Dai7General Surgery Center, The General Hospital of Western Theater CommandGeneral Surgery Center, The General Hospital of Western Theater CommandDepartment of General Medical Practice, The General Hospital of Western Theater CommandDepartment of General Surgery, Affiliated Jinling Hospital, Medical School of Nanjing UniversityDepartment of General Surgery, Affiliated Hospital of Southwest Medical University, The General Hospital of Western Theater CommandDepartment of General Surgery, Affiliated Hospital of Southwest Medical University, The General Hospital of Western Theater CommandGeneral Surgery Department, Chengdu Sixth People’s HospitalGeneral Surgery Center, The General Hospital of Western Theater CommandAbstract The COVID-19 pandemic has significantly impacted the quality of life (QoL) of individuals in China, affecting both their physical and mental well-being. This study aims to comprehensively analyze the factors influencing QoL in China during the pandemic. In 2022, we collected data using a self-developed questionnaire (dataset 2) and obtained dataset 1 from the 2021 China General Social Survey (CGSS). After confirming the scale’s reliability and validity, we employed a random forest algorithm to prioritize the factors. Subsequently, Mendelian randomization analyses were conducted using data from the MRC IEU OpenGWAS data infrastructure. By comparing data from two periods with low and high infection rates, the results showed that among the various influences brought about by the prevalence of COVID-19, sleep disorders have a significant and widespread impact on the quality of life, especially for the elderly. Through the inclusion of Mendelian randomization analysis, we found that COVID-19 have a relative increase in the risk of developing insomnia by approximately 26.7% (OR = 1.267). These findings can inform the development of targeted interventions and strategies to improve overall well-being.https://doi.org/10.1038/s41598-024-81579-5Quality of lifeSleep disorderCOVID-19Mendelian randomizationSF-12 scaleMental health |
| spellingShingle | Kexin Jiang Hua Ji Lihong Ma Zhirong Zhao Yiwen Zhao Jiajie Feng Zheng Tang Ruiwu Dai Understanding the impact of COVID-19 on quality of life using surveys and Mendelian randomization Scientific Reports Quality of life Sleep disorder COVID-19 Mendelian randomization SF-12 scale Mental health |
| title | Understanding the impact of COVID-19 on quality of life using surveys and Mendelian randomization |
| title_full | Understanding the impact of COVID-19 on quality of life using surveys and Mendelian randomization |
| title_fullStr | Understanding the impact of COVID-19 on quality of life using surveys and Mendelian randomization |
| title_full_unstemmed | Understanding the impact of COVID-19 on quality of life using surveys and Mendelian randomization |
| title_short | Understanding the impact of COVID-19 on quality of life using surveys and Mendelian randomization |
| title_sort | understanding the impact of covid 19 on quality of life using surveys and mendelian randomization |
| topic | Quality of life Sleep disorder COVID-19 Mendelian randomization SF-12 scale Mental health |
| url | https://doi.org/10.1038/s41598-024-81579-5 |
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