Primary diffuse large B-cell lymphoma of the prostate: Histopathological diagnosis of a rare entity in the prostate
Lymphoma of the prostate is rare whether it is primary extranodal lymphoma or secondary involvement of the prostate by primary lymphoma elsewhere. Of all the lymphomas of the prostate, primary lymphomas of the prostrate are very rare. Although less frequent, it should be a differential diagnosis whe...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_325_23 |
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| author | Richa Sharma Sumit Bansal Aparna Gangoli |
| author_facet | Richa Sharma Sumit Bansal Aparna Gangoli |
| author_sort | Richa Sharma |
| collection | DOAJ |
| description | Lymphoma of the prostate is rare whether it is primary extranodal lymphoma or secondary involvement of the prostate by primary lymphoma elsewhere. Of all the lymphomas of the prostate, primary lymphomas of the prostrate are very rare. Although less frequent, it should be a differential diagnosis when evaluating prostate tumors. Here, we report a case of a 61-year-old man who presented with hematuria with clot retention. A cystoscopy with clot removal and transurethral resection of the prostate (TURP) was performed. This biopsy was sent for histopathological examination at an external center, where a diagnosis of benign prostatic hyperplasia was given. Fifteen days later, the patient presented with hematuria again. On examination, clots were present in the bladder. There was significant prostatomegaly. A re-resection of the prostate was performed and sent for another review to us. The biopsy was reported as high-grade round cell neoplasm, most likely lymphoma. Immunohistochemistry (IHC) was recommended for confirmation. Tumor cells showed immunoreactivity for CD20, B-cell Lymphoma (BCL)-2, BCL-6, Myelocytomatosis (c-Myc), and multiple myeloma 1 (MUM1). Cluster Differentiation (CD)10 was negative. Kiel-67 was high. A final diagnosis of double-expressor diffuse large B-cell lymphoma (DLBCL) of non-germinal center type was made. We share this case to emphasize the fact that primary lymphoma of the prostate is primarily a histopathological diagnosis as the clinical presentation is not unique. Owing to its rarity, the clinical and histopathological suspicion is low. Hence, keeping the differential in mind while evaluating prostate biopsy is beneficial in a timely diagnosis of the entity as the management of prostatic carcinoma and lymphoma is different. |
| format | Article |
| id | doaj-art-3c36ab4f83b149f8b4cad1d218fb5d92 |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-3c36ab4f83b149f8b4cad1d218fb5d922025-01-10T10:29:00ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302024-12-0167493994310.4103/ijpm.ijpm_325_23Primary diffuse large B-cell lymphoma of the prostate: Histopathological diagnosis of a rare entity in the prostateRicha SharmaSumit BansalAparna GangoliLymphoma of the prostate is rare whether it is primary extranodal lymphoma or secondary involvement of the prostate by primary lymphoma elsewhere. Of all the lymphomas of the prostate, primary lymphomas of the prostrate are very rare. Although less frequent, it should be a differential diagnosis when evaluating prostate tumors. Here, we report a case of a 61-year-old man who presented with hematuria with clot retention. A cystoscopy with clot removal and transurethral resection of the prostate (TURP) was performed. This biopsy was sent for histopathological examination at an external center, where a diagnosis of benign prostatic hyperplasia was given. Fifteen days later, the patient presented with hematuria again. On examination, clots were present in the bladder. There was significant prostatomegaly. A re-resection of the prostate was performed and sent for another review to us. The biopsy was reported as high-grade round cell neoplasm, most likely lymphoma. Immunohistochemistry (IHC) was recommended for confirmation. Tumor cells showed immunoreactivity for CD20, B-cell Lymphoma (BCL)-2, BCL-6, Myelocytomatosis (c-Myc), and multiple myeloma 1 (MUM1). Cluster Differentiation (CD)10 was negative. Kiel-67 was high. A final diagnosis of double-expressor diffuse large B-cell lymphoma (DLBCL) of non-germinal center type was made. We share this case to emphasize the fact that primary lymphoma of the prostate is primarily a histopathological diagnosis as the clinical presentation is not unique. Owing to its rarity, the clinical and histopathological suspicion is low. Hence, keeping the differential in mind while evaluating prostate biopsy is beneficial in a timely diagnosis of the entity as the management of prostatic carcinoma and lymphoma is different.https://journals.lww.com/10.4103/ijpm.ijpm_325_23double-expressor dlbclprimary diffuse large b-cell lymphoma of the prostateprimary lymphoma prostate |
| spellingShingle | Richa Sharma Sumit Bansal Aparna Gangoli Primary diffuse large B-cell lymphoma of the prostate: Histopathological diagnosis of a rare entity in the prostate Indian Journal of Pathology and Microbiology double-expressor dlbcl primary diffuse large b-cell lymphoma of the prostate primary lymphoma prostate |
| title | Primary diffuse large B-cell lymphoma of the prostate: Histopathological diagnosis of a rare entity in the prostate |
| title_full | Primary diffuse large B-cell lymphoma of the prostate: Histopathological diagnosis of a rare entity in the prostate |
| title_fullStr | Primary diffuse large B-cell lymphoma of the prostate: Histopathological diagnosis of a rare entity in the prostate |
| title_full_unstemmed | Primary diffuse large B-cell lymphoma of the prostate: Histopathological diagnosis of a rare entity in the prostate |
| title_short | Primary diffuse large B-cell lymphoma of the prostate: Histopathological diagnosis of a rare entity in the prostate |
| title_sort | primary diffuse large b cell lymphoma of the prostate histopathological diagnosis of a rare entity in the prostate |
| topic | double-expressor dlbcl primary diffuse large b-cell lymphoma of the prostate primary lymphoma prostate |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_325_23 |
| work_keys_str_mv | AT richasharma primarydiffuselargebcelllymphomaoftheprostatehistopathologicaldiagnosisofarareentityintheprostate AT sumitbansal primarydiffuselargebcelllymphomaoftheprostatehistopathologicaldiagnosisofarareentityintheprostate AT aparnagangoli primarydiffuselargebcelllymphomaoftheprostatehistopathologicaldiagnosisofarareentityintheprostate |