Establishment and Clinical Application of Rh Blood Group Bank in the East China Region
Yiming Jin,1,* Xiaoyan Fu,2,* Shuhong Xie,3 Zhen Liu,1 Zihao Xu,1 Mingyuan Wang,1 Yihan Wang,1 Rong Lu,1 Lingling Wang1 1Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China; 2Department of Blood Screening Test, Tai Cang Blood Branch Station, Ta...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-02-01
|
| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/establishment-and-clinical-application-of-rh-blood-group-bank-in-the-e-peer-reviewed-fulltext-article-IJGM |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823857967673376768 |
|---|---|
| author | Jin Y Fu X Xie S Liu Z Xu Z Wang M Wang Y Lu R Wang L |
| author_facet | Jin Y Fu X Xie S Liu Z Xu Z Wang M Wang Y Lu R Wang L |
| author_sort | Jin Y |
| collection | DOAJ |
| description | Yiming Jin,1,* Xiaoyan Fu,2,* Shuhong Xie,3 Zhen Liu,1 Zihao Xu,1 Mingyuan Wang,1 Yihan Wang,1 Rong Lu,1 Lingling Wang1 1Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China; 2Department of Blood Screening Test, Tai Cang Blood Branch Station, Tai Cang, People’s Republic of China; 3Division of Transfusion Medicine, Suzhou Blood Center, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lingling Wang; Rong Lu, Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China, Email linglingwang0716@163.com; cv-25a@163.comPurpose: To investigate the expression and distribution of Rh phenotypes (C, c, D, E, e) among voluntary blood donors in a specific region of East China, to establish a regional Rh phenotype database, and to enhance the precision and efficacy of clinical blood transfusions.Patients and Methods: A total of 28979 blood samples were collected from voluntary donors at a central blood station in East China between May 2023 and December 2023. An automated blood type analyzer was used to determine Rh phenotypes, which were then applied clinically for ABO and Rh blood type-matching in transfusions.Results: Analysis of 28672 RhD-positive donors identified 13 RhD variants and eight Rh phenotypes, with the most common being CCee (42.69%) and CcEe (35.27%). Antigen frequencies were e (92.07%), C (87.85%), c (56.75%), and E (47.65%). Among 307 RhD-negative donors, seven Rh phenotypes were identified, with ccee (60.26%) and Ccee (29.32%) being the predominant ones. Antigen frequencies were e (99.67%), c (96.09%), C (34.53%), and E (6.84%). These findings supported 1834 ABO- and Rh- blood type-matching transfusions, but no significant difference was observed between ABO-compatible and dual-system compatible transfusions (p > 0.05). Additionally, it was found that there are significant differences compared to populations from India and other regions (p > 0.05).Conclusion: In this region of East China, the prevalence of RhD variants among voluntary blood donors was 0.045%. The predominant Rh phenotypes were CCDee and CcDEe, with the highest frequencies observed for the e and C antigens. And the frequency of Rh phenotypes in this region differs from related studies in other areas. It is essential to strengthen the establishment of a rare blood type database in East China to provide data support for clinical compatible blood transfusion.Keywords: Rh phenotype, Rh antigen, Rh antibody, compatible blood transfusion |
| format | Article |
| id | doaj-art-3c308c8734844e9abc4f578467abe064 |
| institution | Kabale University |
| issn | 1178-7074 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj-art-3c308c8734844e9abc4f578467abe0642025-02-11T17:30:55ZengDove Medical PressInternational Journal of General Medicine1178-70742025-02-01Volume 18717724100091Establishment and Clinical Application of Rh Blood Group Bank in the East China RegionJin YFu XXie SLiu ZXu ZWang MWang YLu RWang LYiming Jin,1,* Xiaoyan Fu,2,* Shuhong Xie,3 Zhen Liu,1 Zihao Xu,1 Mingyuan Wang,1 Yihan Wang,1 Rong Lu,1 Lingling Wang1 1Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China; 2Department of Blood Screening Test, Tai Cang Blood Branch Station, Tai Cang, People’s Republic of China; 3Division of Transfusion Medicine, Suzhou Blood Center, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lingling Wang; Rong Lu, Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China, Email linglingwang0716@163.com; cv-25a@163.comPurpose: To investigate the expression and distribution of Rh phenotypes (C, c, D, E, e) among voluntary blood donors in a specific region of East China, to establish a regional Rh phenotype database, and to enhance the precision and efficacy of clinical blood transfusions.Patients and Methods: A total of 28979 blood samples were collected from voluntary donors at a central blood station in East China between May 2023 and December 2023. An automated blood type analyzer was used to determine Rh phenotypes, which were then applied clinically for ABO and Rh blood type-matching in transfusions.Results: Analysis of 28672 RhD-positive donors identified 13 RhD variants and eight Rh phenotypes, with the most common being CCee (42.69%) and CcEe (35.27%). Antigen frequencies were e (92.07%), C (87.85%), c (56.75%), and E (47.65%). Among 307 RhD-negative donors, seven Rh phenotypes were identified, with ccee (60.26%) and Ccee (29.32%) being the predominant ones. Antigen frequencies were e (99.67%), c (96.09%), C (34.53%), and E (6.84%). These findings supported 1834 ABO- and Rh- blood type-matching transfusions, but no significant difference was observed between ABO-compatible and dual-system compatible transfusions (p > 0.05). Additionally, it was found that there are significant differences compared to populations from India and other regions (p > 0.05).Conclusion: In this region of East China, the prevalence of RhD variants among voluntary blood donors was 0.045%. The predominant Rh phenotypes were CCDee and CcDEe, with the highest frequencies observed for the e and C antigens. And the frequency of Rh phenotypes in this region differs from related studies in other areas. It is essential to strengthen the establishment of a rare blood type database in East China to provide data support for clinical compatible blood transfusion.Keywords: Rh phenotype, Rh antigen, Rh antibody, compatible blood transfusionhttps://www.dovepress.com/establishment-and-clinical-application-of-rh-blood-group-bank-in-the-e-peer-reviewed-fulltext-article-IJGMrh phenotyperh antigenrh antibodycompatible blood transfusion |
| spellingShingle | Jin Y Fu X Xie S Liu Z Xu Z Wang M Wang Y Lu R Wang L Establishment and Clinical Application of Rh Blood Group Bank in the East China Region International Journal of General Medicine rh phenotype rh antigen rh antibody compatible blood transfusion |
| title | Establishment and Clinical Application of Rh Blood Group Bank in the East China Region |
| title_full | Establishment and Clinical Application of Rh Blood Group Bank in the East China Region |
| title_fullStr | Establishment and Clinical Application of Rh Blood Group Bank in the East China Region |
| title_full_unstemmed | Establishment and Clinical Application of Rh Blood Group Bank in the East China Region |
| title_short | Establishment and Clinical Application of Rh Blood Group Bank in the East China Region |
| title_sort | establishment and clinical application of rh blood group bank in the east china region |
| topic | rh phenotype rh antigen rh antibody compatible blood transfusion |
| url | https://www.dovepress.com/establishment-and-clinical-application-of-rh-blood-group-bank-in-the-e-peer-reviewed-fulltext-article-IJGM |
| work_keys_str_mv | AT jiny establishmentandclinicalapplicationofrhbloodgroupbankintheeastchinaregion AT fux establishmentandclinicalapplicationofrhbloodgroupbankintheeastchinaregion AT xies establishmentandclinicalapplicationofrhbloodgroupbankintheeastchinaregion AT liuz establishmentandclinicalapplicationofrhbloodgroupbankintheeastchinaregion AT xuz establishmentandclinicalapplicationofrhbloodgroupbankintheeastchinaregion AT wangm establishmentandclinicalapplicationofrhbloodgroupbankintheeastchinaregion AT wangy establishmentandclinicalapplicationofrhbloodgroupbankintheeastchinaregion AT lur establishmentandclinicalapplicationofrhbloodgroupbankintheeastchinaregion AT wangl establishmentandclinicalapplicationofrhbloodgroupbankintheeastchinaregion |