Polymorphisms of angiotensin converting enzyme,angiotensinogen and endothelial nitric oxide synthase gene in IgA nephropathy in Xinjiang Uygur
Objective To investigate the correlation between single nucleotide polymorphism of angiotensin converting enzyme( ACE),angiotensinogen( AGT) and endothelial nitric oxide synthase( eNOS)with IgA nephropathy. Methods A total of 90 Xinjiang Uygur were enrolled,including 45 cases of IgA nephropathy and...
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Editorial Department of Journal of Clinical Nephrology
2017-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| author | SONG Xue XU Dan ZHAO Zong-feng LU Chen |
| author_facet | SONG Xue XU Dan ZHAO Zong-feng LU Chen |
| author_sort | SONG Xue |
| collection | DOAJ |
| description | Objective To investigate the correlation between single nucleotide polymorphism of angiotensin converting enzyme( ACE),angiotensinogen( AGT) and endothelial nitric oxide synthase( eNOS)with IgA nephropathy. Methods A total of 90 Xinjiang Uygur were enrolled,including 45 cases of IgA nephropathy and 45 healthy controls. Results The frequencies of genotype and allele distribution in ACE I/D and AGT M235 T showed no significant difference( P > 0. 05) between IgA nephropathy and control groups.The frequencies of eNOS G894 T GG genotype and G allele( 62. 2% and 75. 6%,respectively) in IgA nephropathy group were significantly higher than those in control group( χ~2= 11. 520,P = 0. 001; χ~2=12. 577,P < 0. 0001,respectively). The serum creatinine in ACE DD genotype [178. 00( 101. 99,204. 24) μmol/L] was significantly higher than that of ACE Ⅱ genotype [78. 27( 64. 23,112. 78) μmol/L] with the difference being statistically significant( P = 0. 018). The association of AGT M235T/eNOS G894 T genotypes and serum creatinine showed no statistically significant difference between the two groups( P > 0. 05). 24-h proteinuria in ACE DD genotype [2. 66( 1. 44,3. 87) g]was significantly higher than that of ACE genotype Ⅱ [1. 31( 0. 14,2. 65) g]( P = 0. 023),with no significant differences between AGT M235 T and eNOS G894 T gene( P > 0. 05). Association of ACE I/D,AGT M235 T and eNOS G894 T genotypes and hematuria showed no statistically significant difference between the two groups( P > 0. 05).Conclusions ACE I/D,and AGT M235 T genes are irrelevant to the susceptibility of patients with IgA nephropathy in Xinjiang Uygur. eNOS gene may be a risk factor in patients with IgA nephropathy. DD genotype in ACE gene is associated with the progression of IgA nephropathy in Xinjiang Uygur. |
| format | Article |
| id | doaj-art-3c2940fa98fe43498bd01026bc8da401 |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2017-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-3c2940fa98fe43498bd01026bc8da4012025-08-20T03:48:58ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902017-01-0115415957916816Polymorphisms of angiotensin converting enzyme,angiotensinogen and endothelial nitric oxide synthase gene in IgA nephropathy in Xinjiang UygurSONG XueXU DanZHAO Zong-fengLU ChenObjective To investigate the correlation between single nucleotide polymorphism of angiotensin converting enzyme( ACE),angiotensinogen( AGT) and endothelial nitric oxide synthase( eNOS)with IgA nephropathy. Methods A total of 90 Xinjiang Uygur were enrolled,including 45 cases of IgA nephropathy and 45 healthy controls. Results The frequencies of genotype and allele distribution in ACE I/D and AGT M235 T showed no significant difference( P > 0. 05) between IgA nephropathy and control groups.The frequencies of eNOS G894 T GG genotype and G allele( 62. 2% and 75. 6%,respectively) in IgA nephropathy group were significantly higher than those in control group( χ~2= 11. 520,P = 0. 001; χ~2=12. 577,P < 0. 0001,respectively). The serum creatinine in ACE DD genotype [178. 00( 101. 99,204. 24) μmol/L] was significantly higher than that of ACE Ⅱ genotype [78. 27( 64. 23,112. 78) μmol/L] with the difference being statistically significant( P = 0. 018). The association of AGT M235T/eNOS G894 T genotypes and serum creatinine showed no statistically significant difference between the two groups( P > 0. 05). 24-h proteinuria in ACE DD genotype [2. 66( 1. 44,3. 87) g]was significantly higher than that of ACE genotype Ⅱ [1. 31( 0. 14,2. 65) g]( P = 0. 023),with no significant differences between AGT M235 T and eNOS G894 T gene( P > 0. 05). Association of ACE I/D,AGT M235 T and eNOS G894 T genotypes and hematuria showed no statistically significant difference between the two groups( P > 0. 05).Conclusions ACE I/D,and AGT M235 T genes are irrelevant to the susceptibility of patients with IgA nephropathy in Xinjiang Uygur. eNOS gene may be a risk factor in patients with IgA nephropathy. DD genotype in ACE gene is associated with the progression of IgA nephropathy in Xinjiang Uygur.http://www.lcszb.com/thesisDetails?columnId=57916816&Fpath=home&index=0IgA nephropathyAngiotensin converting enzymeAangiotensinogenEndothelial ni tricoxide synthaseSingle nucleotide polymorphism |
| spellingShingle | SONG Xue XU Dan ZHAO Zong-feng LU Chen Polymorphisms of angiotensin converting enzyme,angiotensinogen and endothelial nitric oxide synthase gene in IgA nephropathy in Xinjiang Uygur Linchuang shenzangbing zazhi IgA nephropathy Angiotensin converting enzyme Aangiotensinogen Endothelial ni tricoxide synthase Single nucleotide polymorphism |
| title | Polymorphisms of angiotensin converting enzyme,angiotensinogen and endothelial nitric oxide synthase gene in IgA nephropathy in Xinjiang Uygur |
| title_full | Polymorphisms of angiotensin converting enzyme,angiotensinogen and endothelial nitric oxide synthase gene in IgA nephropathy in Xinjiang Uygur |
| title_fullStr | Polymorphisms of angiotensin converting enzyme,angiotensinogen and endothelial nitric oxide synthase gene in IgA nephropathy in Xinjiang Uygur |
| title_full_unstemmed | Polymorphisms of angiotensin converting enzyme,angiotensinogen and endothelial nitric oxide synthase gene in IgA nephropathy in Xinjiang Uygur |
| title_short | Polymorphisms of angiotensin converting enzyme,angiotensinogen and endothelial nitric oxide synthase gene in IgA nephropathy in Xinjiang Uygur |
| title_sort | polymorphisms of angiotensin converting enzyme angiotensinogen and endothelial nitric oxide synthase gene in iga nephropathy in xinjiang uygur |
| topic | IgA nephropathy Angiotensin converting enzyme Aangiotensinogen Endothelial ni tricoxide synthase Single nucleotide polymorphism |
| url | http://www.lcszb.com/thesisDetails?columnId=57916816&Fpath=home&index=0 |
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