The glycerol stabilized calcium phosphate cluster for rapid remineralization of tooth enamel by a water-triggered transformation
Abstract Remineralization is a common strategy for the repair of early demineralized tooth enamels, but the harsh dynamic oral environment often hampers its efficacy. Rapid remineralization is expected to address this challenge, however, the stabilizers of remineralization materials often resist the...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54785-y |
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| author | Nan Luo Bing-Qiang Lu Yu-Wei Deng Hua Zeng Yu Zhang Jing-Yu Zhan Xiao-Chen Xu Gui-Zhi Cao Jin Wen Zhiyuan Zhang Xi-Ping Feng Xinquan Jiang Feng Chen Xi Chen |
| author_facet | Nan Luo Bing-Qiang Lu Yu-Wei Deng Hua Zeng Yu Zhang Jing-Yu Zhan Xiao-Chen Xu Gui-Zhi Cao Jin Wen Zhiyuan Zhang Xi-Ping Feng Xinquan Jiang Feng Chen Xi Chen |
| author_sort | Nan Luo |
| collection | DOAJ |
| description | Abstract Remineralization is a common strategy for the repair of early demineralized tooth enamels, but the harsh dynamic oral environment often hampers its efficacy. Rapid remineralization is expected to address this challenge, however, the stabilizers of remineralization materials often resist their transformation required for repair. Here, by dissolving the ions of calcium and phosphate in glycerol-dominant solvents, we obtain the calcium phosphate clusters (1–2 nm), which are stabilized by glycerol (with high viscosity and affinity to clusters), but can perform a fast enamel repair via the water-triggered transformation in both static and dynamic environments. Upon the in vitro and in vivo (female Sprague-Dawley rats) studies, the clusters swiftly enter the nano-/micro-sized enamel defect sites, then form a compact hydroxyapatite repair layer within a short time (30 min, much faster than the conventional materials), and significantly recovers mechanical properties. This material is promising for large-scale preparation and applications in dental remineralization. |
| format | Article |
| id | doaj-art-3c280904fa854022b3fdf1c05257229b |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-3c280904fa854022b3fdf1c05257229b2025-01-05T12:38:49ZengNature PortfolioNature Communications2041-17232025-01-0116111310.1038/s41467-024-54785-yThe glycerol stabilized calcium phosphate cluster for rapid remineralization of tooth enamel by a water-triggered transformationNan Luo0Bing-Qiang Lu1Yu-Wei Deng2Hua Zeng3Yu Zhang4Jing-Yu Zhan5Xiao-Chen Xu6Gui-Zhi Cao7Jin Wen8Zhiyuan Zhang9Xi-Ping Feng10Xinquan Jiang11Feng Chen12Xi Chen13Department of Preventive Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineCenter for Orthopedic Science and Translational Medicine, Department of Orthopedic, Spinal Pain Research Institute, Shanghai Tenth People’s Hospital, School of Medicine, Tongji UniversityCollege of Stomatology, Shanghai Jiao Tong UniversityCenter for Orthopedic Science and Translational Medicine, Department of Orthopedic, Spinal Pain Research Institute, Shanghai Tenth People’s Hospital, School of Medicine, Tongji UniversityDepartment of Preventive Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Preventive Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Preventive Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineCollege of Stomatology, Shanghai Jiao Tong UniversityCollege of Stomatology, Shanghai Jiao Tong UniversityCollege of Stomatology, Shanghai Jiao Tong UniversityDepartment of Preventive Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineCollege of Stomatology, Shanghai Jiao Tong UniversityCenter for Orthopedic Science and Translational Medicine, Department of Orthopedic, Spinal Pain Research Institute, Shanghai Tenth People’s Hospital, School of Medicine, Tongji UniversityDepartment of Preventive Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineAbstract Remineralization is a common strategy for the repair of early demineralized tooth enamels, but the harsh dynamic oral environment often hampers its efficacy. Rapid remineralization is expected to address this challenge, however, the stabilizers of remineralization materials often resist their transformation required for repair. Here, by dissolving the ions of calcium and phosphate in glycerol-dominant solvents, we obtain the calcium phosphate clusters (1–2 nm), which are stabilized by glycerol (with high viscosity and affinity to clusters), but can perform a fast enamel repair via the water-triggered transformation in both static and dynamic environments. Upon the in vitro and in vivo (female Sprague-Dawley rats) studies, the clusters swiftly enter the nano-/micro-sized enamel defect sites, then form a compact hydroxyapatite repair layer within a short time (30 min, much faster than the conventional materials), and significantly recovers mechanical properties. This material is promising for large-scale preparation and applications in dental remineralization.https://doi.org/10.1038/s41467-024-54785-y |
| spellingShingle | Nan Luo Bing-Qiang Lu Yu-Wei Deng Hua Zeng Yu Zhang Jing-Yu Zhan Xiao-Chen Xu Gui-Zhi Cao Jin Wen Zhiyuan Zhang Xi-Ping Feng Xinquan Jiang Feng Chen Xi Chen The glycerol stabilized calcium phosphate cluster for rapid remineralization of tooth enamel by a water-triggered transformation Nature Communications |
| title | The glycerol stabilized calcium phosphate cluster for rapid remineralization of tooth enamel by a water-triggered transformation |
| title_full | The glycerol stabilized calcium phosphate cluster for rapid remineralization of tooth enamel by a water-triggered transformation |
| title_fullStr | The glycerol stabilized calcium phosphate cluster for rapid remineralization of tooth enamel by a water-triggered transformation |
| title_full_unstemmed | The glycerol stabilized calcium phosphate cluster for rapid remineralization of tooth enamel by a water-triggered transformation |
| title_short | The glycerol stabilized calcium phosphate cluster for rapid remineralization of tooth enamel by a water-triggered transformation |
| title_sort | glycerol stabilized calcium phosphate cluster for rapid remineralization of tooth enamel by a water triggered transformation |
| url | https://doi.org/10.1038/s41467-024-54785-y |
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