Fibroblast growth factor 8: Multifaceted role in development and developmental disorder
Fibroblast growth factor 8 (FGF8), a secreted signaling molecule, involves in regulating cell survival, proliferation, migration, and differentiation. It exhibits a highly dynamic gene expression pattern throughout embryonic development, participates in craniofacial structures, limbs, internal organ...
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KeAi Communications Co., Ltd.
2025-09-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304225000133 |
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| author | Huamin Yin Lian Duan Zhendong Wang Li Liu Jingling Shen |
| author_facet | Huamin Yin Lian Duan Zhendong Wang Li Liu Jingling Shen |
| author_sort | Huamin Yin |
| collection | DOAJ |
| description | Fibroblast growth factor 8 (FGF8), a secreted signaling molecule, involves in regulating cell survival, proliferation, migration, and differentiation. It exhibits a highly dynamic gene expression pattern throughout embryonic development, participates in craniofacial structures, limbs, internal organs, brain development, and is crucial during organogenesis. The dysregulation of precise localization and dosage of FGF8 at distinct embryonic stages can lead to developmental multiorgan abnormalities. This comprehensive review explores the FGF8 expression in humans and mice, summarizes the involvement of FGF8 in various tissues including craniofacial, limbs, cardiovascular and urogenital system, nephrogenesis, lung, and brain development as well as developmental abnormalities resulting from the aberrant regulations of FGF8 such as skeletal abnormalities, ciliopathies, and holoprosencephaly. |
| format | Article |
| id | doaj-art-3c1cccfa87fd4a3698736eadce5ae19a |
| institution | Kabale University |
| issn | 2352-3042 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj-art-3c1cccfa87fd4a3698736eadce5ae19a2025-08-20T03:30:37ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-09-0112510152410.1016/j.gendis.2025.101524Fibroblast growth factor 8: Multifaceted role in development and developmental disorderHuamin Yin0Lian Duan1Zhendong Wang2Li Liu3Jingling Shen4Institute of Life Sciences, College of Life and Environmental Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, China; Central Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaCentral Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaKey Laboratory of Interventional Pulmonology of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaInstitute of Life Sciences, College of Life and Environmental Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, China; Corresponding author. Institute of Life Sciences, College of Life and Environmental Sciences, Wenzhou University, Chashan University Town, Wenzhou, Zhejiang 325035, China.Institute of Life Sciences, College of Life and Environmental Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, China; Corresponding author. Institute of Life Sciences, College of Life and Environmental Sciences, Wenzhou University, Chashan University Town, Wenzhou, Zhejiang 325035, China.Fibroblast growth factor 8 (FGF8), a secreted signaling molecule, involves in regulating cell survival, proliferation, migration, and differentiation. It exhibits a highly dynamic gene expression pattern throughout embryonic development, participates in craniofacial structures, limbs, internal organs, brain development, and is crucial during organogenesis. The dysregulation of precise localization and dosage of FGF8 at distinct embryonic stages can lead to developmental multiorgan abnormalities. This comprehensive review explores the FGF8 expression in humans and mice, summarizes the involvement of FGF8 in various tissues including craniofacial, limbs, cardiovascular and urogenital system, nephrogenesis, lung, and brain development as well as developmental abnormalities resulting from the aberrant regulations of FGF8 such as skeletal abnormalities, ciliopathies, and holoprosencephaly.http://www.sciencedirect.com/science/article/pii/S2352304225000133Developmental disordersEmbryonic developmentFGF8OrganogenesisSingle cell RNA sequencing |
| spellingShingle | Huamin Yin Lian Duan Zhendong Wang Li Liu Jingling Shen Fibroblast growth factor 8: Multifaceted role in development and developmental disorder Genes and Diseases Developmental disorders Embryonic development FGF8 Organogenesis Single cell RNA sequencing |
| title | Fibroblast growth factor 8: Multifaceted role in development and developmental disorder |
| title_full | Fibroblast growth factor 8: Multifaceted role in development and developmental disorder |
| title_fullStr | Fibroblast growth factor 8: Multifaceted role in development and developmental disorder |
| title_full_unstemmed | Fibroblast growth factor 8: Multifaceted role in development and developmental disorder |
| title_short | Fibroblast growth factor 8: Multifaceted role in development and developmental disorder |
| title_sort | fibroblast growth factor 8 multifaceted role in development and developmental disorder |
| topic | Developmental disorders Embryonic development FGF8 Organogenesis Single cell RNA sequencing |
| url | http://www.sciencedirect.com/science/article/pii/S2352304225000133 |
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