Assessment of sestrin 2 as a sepsis marker and predictor of disease severity
Introduction Sestrin 2 is considered a stress-inducible antioxidant protein. This study was aimed to evaluate sestrin 2 in subjects with sepsis, and its correlation with clinical severity and mortality.Methods Sepsis and control group patients were followed from admission to discharge. A blood sampl...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | The Aging Male |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13685538.2024.2424300 |
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| author | Osman Baspınar Derya Kocer Kaniye Aydın Oguzhan Sıtkı Dizdar |
| author_facet | Osman Baspınar Derya Kocer Kaniye Aydın Oguzhan Sıtkı Dizdar |
| author_sort | Osman Baspınar |
| collection | DOAJ |
| description | Introduction Sestrin 2 is considered a stress-inducible antioxidant protein. This study was aimed to evaluate sestrin 2 in subjects with sepsis, and its correlation with clinical severity and mortality.Methods Sepsis and control group patients were followed from admission to discharge. A blood sample was taken at admission for determination of serum sestrin 2 level.Results Of the total 42 patients with sepsis, there were 25 females and the mean age was 74.9 years. The sestrin 2 levels were significantly higher in the sepsis group. The optimum sestrin 2 cut-off point of ≥3.13 ng/mL had 95.2% sensitivity and 71.4% specificity for sepsis (p < .001). Sestrin 2 levels were higher in patients who needed renal replacement therapy (p = .018), patients who needed vasopressor therapy (p = .001) and patients with organ dysfunction (p = .002). The sestrin 2 level was significantly correlated with Acute Physiology and Chronic Health Evaluation (APACHE) II score, Nutrition Risk in the Critically Ill (NUTRIC) Score, C-reactive protein and albumin. Sestrin 2 levels were not associated with 30 d mortality in sepsis patients.Conclusions Sestrin 2 was significantly higher in the sepsis patients and associated with sepsis related adverse clinical outcomes. These results provided information concerning the clinical utility of sestrin 2. |
| format | Article |
| id | doaj-art-3c1c3704b35c4ed0ba31e6fa86f20e2b |
| institution | OA Journals |
| issn | 1368-5538 1473-0790 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | The Aging Male |
| spelling | doaj-art-3c1c3704b35c4ed0ba31e6fa86f20e2b2025-08-20T02:18:20ZengTaylor & Francis GroupThe Aging Male1368-55381473-07902024-12-0127110.1080/13685538.2024.2424300Assessment of sestrin 2 as a sepsis marker and predictor of disease severityOsman Baspınar0Derya Kocer1Kaniye Aydın2Oguzhan Sıtkı Dizdar3Department of Internal Medicine, Kayseri City Training and Research Hospital, Kayseri, TurkeyDepartment of Biochemistry, Kayseri City Training and Research Hospital, Kayseri, TurkeyDepartment of Internal Medicine Division of Intensive Care, Kayseri City Training and Research Hospital, Kayseri, TurkeyDepartment of Internal Medicine and Clinical Nutrition Unit, Kayseri City Training and Research Hospital University of Health Sciences, Kayseri, TurkeyIntroduction Sestrin 2 is considered a stress-inducible antioxidant protein. This study was aimed to evaluate sestrin 2 in subjects with sepsis, and its correlation with clinical severity and mortality.Methods Sepsis and control group patients were followed from admission to discharge. A blood sample was taken at admission for determination of serum sestrin 2 level.Results Of the total 42 patients with sepsis, there were 25 females and the mean age was 74.9 years. The sestrin 2 levels were significantly higher in the sepsis group. The optimum sestrin 2 cut-off point of ≥3.13 ng/mL had 95.2% sensitivity and 71.4% specificity for sepsis (p < .001). Sestrin 2 levels were higher in patients who needed renal replacement therapy (p = .018), patients who needed vasopressor therapy (p = .001) and patients with organ dysfunction (p = .002). The sestrin 2 level was significantly correlated with Acute Physiology and Chronic Health Evaluation (APACHE) II score, Nutrition Risk in the Critically Ill (NUTRIC) Score, C-reactive protein and albumin. Sestrin 2 levels were not associated with 30 d mortality in sepsis patients.Conclusions Sestrin 2 was significantly higher in the sepsis patients and associated with sepsis related adverse clinical outcomes. These results provided information concerning the clinical utility of sestrin 2.https://www.tandfonline.com/doi/10.1080/13685538.2024.2424300Sepsissestrin 2intensive care unitprognosisC-reactive protein |
| spellingShingle | Osman Baspınar Derya Kocer Kaniye Aydın Oguzhan Sıtkı Dizdar Assessment of sestrin 2 as a sepsis marker and predictor of disease severity The Aging Male Sepsis sestrin 2 intensive care unit prognosis C-reactive protein |
| title | Assessment of sestrin 2 as a sepsis marker and predictor of disease severity |
| title_full | Assessment of sestrin 2 as a sepsis marker and predictor of disease severity |
| title_fullStr | Assessment of sestrin 2 as a sepsis marker and predictor of disease severity |
| title_full_unstemmed | Assessment of sestrin 2 as a sepsis marker and predictor of disease severity |
| title_short | Assessment of sestrin 2 as a sepsis marker and predictor of disease severity |
| title_sort | assessment of sestrin 2 as a sepsis marker and predictor of disease severity |
| topic | Sepsis sestrin 2 intensive care unit prognosis C-reactive protein |
| url | https://www.tandfonline.com/doi/10.1080/13685538.2024.2424300 |
| work_keys_str_mv | AT osmanbaspınar assessmentofsestrin2asasepsismarkerandpredictorofdiseaseseverity AT deryakocer assessmentofsestrin2asasepsismarkerandpredictorofdiseaseseverity AT kaniyeaydın assessmentofsestrin2asasepsismarkerandpredictorofdiseaseseverity AT oguzhansıtkıdizdar assessmentofsestrin2asasepsismarkerandpredictorofdiseaseseverity |