Danger Signals Activating the Immune Response after Trauma
Sterile injury can cause a systemic inflammatory response syndrome (SIRS) that resembles the host response during sepsis. The inflammatory response following trauma comprises various systems of the human body which are cross-linked with each other within a highly complex network of inflammation. End...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/315941 |
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| _version_ | 1832554806073360384 |
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| author | Stefanie Hirsiger Hans-Peter Simmen Clément M. L. Werner Guido A. Wanner Daniel Rittirsch |
| author_facet | Stefanie Hirsiger Hans-Peter Simmen Clément M. L. Werner Guido A. Wanner Daniel Rittirsch |
| author_sort | Stefanie Hirsiger |
| collection | DOAJ |
| description | Sterile injury can cause a systemic inflammatory response syndrome (SIRS) that resembles the host response during sepsis. The inflammatory response following trauma comprises various systems of the human body which are cross-linked with each other within a highly complex network of inflammation. Endogenous danger signals (danger-associated molecular patterns; DAMPs; alarmins) as well as exogenous pathogen-associated molecular patterns (PAMPs) play a crucial role in the initiation of the immune response. With popularization of the “danger theory,” numerous DAMPs and PAMPs and their corresponding pathogen-recognition receptors have been identified. In this paper, we highlight the role of the DAMPs high-mobility group box protein 1 (HMGB1), interleukin-1α (IL-1α), and interleukin-33 (IL-33) as unique dual-function mediators as well as mitochondrial danger signals released upon cellular trauma and necrosis. |
| format | Article |
| id | doaj-art-3c14a042ec8b4c409562959f22d039ca |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3c14a042ec8b4c409562959f22d039ca2025-02-03T05:50:29ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/315941315941Danger Signals Activating the Immune Response after TraumaStefanie Hirsiger0Hans-Peter Simmen1Clément M. L. Werner2Guido A. Wanner3Daniel Rittirsch4Division of Trauma Surgery, Department of Surgery, University Hospital Zurich, 8091 Zurich, SwitzerlandDivision of Trauma Surgery, Department of Surgery, University Hospital Zurich, 8091 Zurich, SwitzerlandDivision of Trauma Surgery, Department of Surgery, University Hospital Zurich, 8091 Zurich, SwitzerlandDivision of Trauma Surgery, Department of Surgery, University Hospital Zurich, 8091 Zurich, SwitzerlandDivision of Trauma Surgery, Department of Surgery, University Hospital Zurich, 8091 Zurich, SwitzerlandSterile injury can cause a systemic inflammatory response syndrome (SIRS) that resembles the host response during sepsis. The inflammatory response following trauma comprises various systems of the human body which are cross-linked with each other within a highly complex network of inflammation. Endogenous danger signals (danger-associated molecular patterns; DAMPs; alarmins) as well as exogenous pathogen-associated molecular patterns (PAMPs) play a crucial role in the initiation of the immune response. With popularization of the “danger theory,” numerous DAMPs and PAMPs and their corresponding pathogen-recognition receptors have been identified. In this paper, we highlight the role of the DAMPs high-mobility group box protein 1 (HMGB1), interleukin-1α (IL-1α), and interleukin-33 (IL-33) as unique dual-function mediators as well as mitochondrial danger signals released upon cellular trauma and necrosis.http://dx.doi.org/10.1155/2012/315941 |
| spellingShingle | Stefanie Hirsiger Hans-Peter Simmen Clément M. L. Werner Guido A. Wanner Daniel Rittirsch Danger Signals Activating the Immune Response after Trauma Mediators of Inflammation |
| title | Danger Signals Activating the Immune Response after Trauma |
| title_full | Danger Signals Activating the Immune Response after Trauma |
| title_fullStr | Danger Signals Activating the Immune Response after Trauma |
| title_full_unstemmed | Danger Signals Activating the Immune Response after Trauma |
| title_short | Danger Signals Activating the Immune Response after Trauma |
| title_sort | danger signals activating the immune response after trauma |
| url | http://dx.doi.org/10.1155/2012/315941 |
| work_keys_str_mv | AT stefaniehirsiger dangersignalsactivatingtheimmuneresponseaftertrauma AT hanspetersimmen dangersignalsactivatingtheimmuneresponseaftertrauma AT clementmlwerner dangersignalsactivatingtheimmuneresponseaftertrauma AT guidoawanner dangersignalsactivatingtheimmuneresponseaftertrauma AT danielrittirsch dangersignalsactivatingtheimmuneresponseaftertrauma |