Design and synthesis of 3,4-seco-Lupane triterpene derivatives: targeting tumor angiogenesis and inducing apoptosis in triple-negative breast cancer

Design and synthesis of 3,4-seco-Lupane triterpene derivatives: targeting tumor angiogenesis and inducing apoptosis in triple-negative breast cancer

BackgroundDue to the lack of effective treatment methods and targeted drugs, triple-negative breast cancer (TNBC) is not only difficult to treat clinically, but also has a poor prognosis for patients. This study aims to develop novel anti-TNBC drug candidates by designing 90 derivatives of 3,4-seco-...

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Bibliographic Details
Main Authors: Chunyu Gao, Hongbo Teng, Wenxin Zhang, Yaru Zhao, Chunguo Cui, Zerbo Patrice, Liyan Wang, Yan Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Chemistry
Subjects:
seco-lupane triterpene derivatives
triple-negative breast cancer
transcriptomics
apoptosis
angiogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2025.1630939/full
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https://www.frontiersin.org/articles/10.3389/fchem.2025.1630939/full

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