Intestinal organoids in inflammatory bowel disease: advances, applications, and future directions
Inflammatory bowel disease (IBD), characterized by chronic gastrointestinal inflammation, is a significant global health challenge. Traditional models often fail to accurately reflect human pathophysiology, leading to suboptimal treatments. This review provides an overview of recent advancements in...
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| Format: | Article |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1517121/full |
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| author | Jianzhen Ren Silin Huang |
| author_facet | Jianzhen Ren Silin Huang |
| author_sort | Jianzhen Ren |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD), characterized by chronic gastrointestinal inflammation, is a significant global health challenge. Traditional models often fail to accurately reflect human pathophysiology, leading to suboptimal treatments. This review provides an overview of recent advancements in intestinal organoid technology and its role in IBD research. Organoids, derived from patient-specific or pluripotent stem cells, retain the genetic, epigenetic, and structural characteristics of the native gut, allowing for precise modeling of key aspects of IBD. Innovations in CRISPR editing, organoid-microbe co-cultures, and organ-on-a-chip systems have enhanced the physiological relevance of these models, facilitating drug discovery and personalized therapy screening. However, challenges such as vascularization deficits and the need for standardized protocols remain. This review underscores the need for interdisciplinary efforts to bridge the gap between models and the complex reality of IBD. Future directions include the development of scalable vascularized models and robust regulatory frameworks to accelerate therapeutic translation. Organoids hold promise for unraveling IBD heterogeneity and transforming disease management. |
| format | Article |
| id | doaj-art-3c111fb826644dda9d0bae45f819a5ba |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-3c111fb826644dda9d0bae45f819a5ba2025-08-20T03:53:12ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-05-011310.3389/fcell.2025.15171211517121Intestinal organoids in inflammatory bowel disease: advances, applications, and future directionsJianzhen RenSilin HuangInflammatory bowel disease (IBD), characterized by chronic gastrointestinal inflammation, is a significant global health challenge. Traditional models often fail to accurately reflect human pathophysiology, leading to suboptimal treatments. This review provides an overview of recent advancements in intestinal organoid technology and its role in IBD research. Organoids, derived from patient-specific or pluripotent stem cells, retain the genetic, epigenetic, and structural characteristics of the native gut, allowing for precise modeling of key aspects of IBD. Innovations in CRISPR editing, organoid-microbe co-cultures, and organ-on-a-chip systems have enhanced the physiological relevance of these models, facilitating drug discovery and personalized therapy screening. However, challenges such as vascularization deficits and the need for standardized protocols remain. This review underscores the need for interdisciplinary efforts to bridge the gap between models and the complex reality of IBD. Future directions include the development of scalable vascularized models and robust regulatory frameworks to accelerate therapeutic translation. Organoids hold promise for unraveling IBD heterogeneity and transforming disease management.https://www.frontiersin.org/articles/10.3389/fcell.2025.1517121/fullintestinal organoidsinflammatory bowel diseaseapplicationprogressnew therapies |
| spellingShingle | Jianzhen Ren Silin Huang Intestinal organoids in inflammatory bowel disease: advances, applications, and future directions Frontiers in Cell and Developmental Biology intestinal organoids inflammatory bowel disease application progress new therapies |
| title | Intestinal organoids in inflammatory bowel disease: advances, applications, and future directions |
| title_full | Intestinal organoids in inflammatory bowel disease: advances, applications, and future directions |
| title_fullStr | Intestinal organoids in inflammatory bowel disease: advances, applications, and future directions |
| title_full_unstemmed | Intestinal organoids in inflammatory bowel disease: advances, applications, and future directions |
| title_short | Intestinal organoids in inflammatory bowel disease: advances, applications, and future directions |
| title_sort | intestinal organoids in inflammatory bowel disease advances applications and future directions |
| topic | intestinal organoids inflammatory bowel disease application progress new therapies |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1517121/full |
| work_keys_str_mv | AT jianzhenren intestinalorganoidsininflammatoryboweldiseaseadvancesapplicationsandfuturedirections AT silinhuang intestinalorganoidsininflammatoryboweldiseaseadvancesapplicationsandfuturedirections |