Enduring memory consequences of early-life stress / adversity: Structural, synaptic, molecular and epigenetic mechanisms
Adverse early life experiences are strongly associated with reduced cognitive function throughout life. The link is strong in many human studies, but these do not enable assigning causality, and the limited access to the live human brain can impede establishing the mechanisms by which early-life adv...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-11-01
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| Series: | Neurobiology of Stress |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352289524000651 |
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| author | Tallie Z. Baram Matthew T. Birnie |
| author_facet | Tallie Z. Baram Matthew T. Birnie |
| author_sort | Tallie Z. Baram |
| collection | DOAJ |
| description | Adverse early life experiences are strongly associated with reduced cognitive function throughout life. The link is strong in many human studies, but these do not enable assigning causality, and the limited access to the live human brain can impede establishing the mechanisms by which early-life adversity (ELA) may induce cognitive problems. In experimental models, artificially imposed chronic ELA/stress results in deficits in hippocampus dependent memory as well as increased vulnerability to the deleterious effects of adult stress on memory. This causal relation of ELA and life-long memory impairments provides a framework to probe the mechanisms by which ELA may lead to human cognitive problems. Here we focus on the consequences of a one-week exposure to adversity during early postnatal life in the rodent, the spectrum of the ensuing memory deficits, and the mechanisms responsible. We highlight molecular, cellular and circuit mechanisms using convergent trans-disciplinary approaches aiming to enable translation of the discoveries in experimental models to the clinic. |
| format | Article |
| id | doaj-art-3c06d141ba774aafa30c0daaefe810e3 |
| institution | DOAJ |
| issn | 2352-2895 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Stress |
| spelling | doaj-art-3c06d141ba774aafa30c0daaefe810e32025-08-20T02:49:02ZengElsevierNeurobiology of Stress2352-28952024-11-013310066910.1016/j.ynstr.2024.100669Enduring memory consequences of early-life stress / adversity: Structural, synaptic, molecular and epigenetic mechanismsTallie Z. Baram0Matthew T. Birnie1Department of Pediatrics, University of California-Irvine, Irvine, CA, USA; Department of Anatomy/Neurobiology, University of California-Irvine, Irvine, CA, USA; Department of Neurology, University of California-Irvine, Irvine, CA, USA; Corresponding author. ZOT 4475, University of California-Irvine, Irvine, California, 92697-4475, USA.Department of Pediatrics, University of California-Irvine, Irvine, CA, USAAdverse early life experiences are strongly associated with reduced cognitive function throughout life. The link is strong in many human studies, but these do not enable assigning causality, and the limited access to the live human brain can impede establishing the mechanisms by which early-life adversity (ELA) may induce cognitive problems. In experimental models, artificially imposed chronic ELA/stress results in deficits in hippocampus dependent memory as well as increased vulnerability to the deleterious effects of adult stress on memory. This causal relation of ELA and life-long memory impairments provides a framework to probe the mechanisms by which ELA may lead to human cognitive problems. Here we focus on the consequences of a one-week exposure to adversity during early postnatal life in the rodent, the spectrum of the ensuing memory deficits, and the mechanisms responsible. We highlight molecular, cellular and circuit mechanisms using convergent trans-disciplinary approaches aiming to enable translation of the discoveries in experimental models to the clinic.http://www.sciencedirect.com/science/article/pii/S2352289524000651MemoryStressCognitiveMicrogliaEpigeneticsSynapses |
| spellingShingle | Tallie Z. Baram Matthew T. Birnie Enduring memory consequences of early-life stress / adversity: Structural, synaptic, molecular and epigenetic mechanisms Neurobiology of Stress Memory Stress Cognitive Microglia Epigenetics Synapses |
| title | Enduring memory consequences of early-life stress / adversity: Structural, synaptic, molecular and epigenetic mechanisms |
| title_full | Enduring memory consequences of early-life stress / adversity: Structural, synaptic, molecular and epigenetic mechanisms |
| title_fullStr | Enduring memory consequences of early-life stress / adversity: Structural, synaptic, molecular and epigenetic mechanisms |
| title_full_unstemmed | Enduring memory consequences of early-life stress / adversity: Structural, synaptic, molecular and epigenetic mechanisms |
| title_short | Enduring memory consequences of early-life stress / adversity: Structural, synaptic, molecular and epigenetic mechanisms |
| title_sort | enduring memory consequences of early life stress adversity structural synaptic molecular and epigenetic mechanisms |
| topic | Memory Stress Cognitive Microglia Epigenetics Synapses |
| url | http://www.sciencedirect.com/science/article/pii/S2352289524000651 |
| work_keys_str_mv | AT talliezbaram enduringmemoryconsequencesofearlylifestressadversitystructuralsynapticmolecularandepigeneticmechanisms AT matthewtbirnie enduringmemoryconsequencesofearlylifestressadversitystructuralsynapticmolecularandepigeneticmechanisms |