DNA vaccine targeting betacoronavirus spike protein blocks neuroinvasion and neuroinflammation in swine via dual antiviral-immunomodulatory action

DNA vaccine targeting betacoronavirus spike protein blocks neuroinvasion and neuroinflammation in swine via dual antiviral-immunomodulatory action

Abstract Porcine hemagglutinating encephalomyelitis virus (PHEV), a neurotropic betacoronavirus, causes fatal neurological disease in piglets, yet no licensed vaccines exist. Here, we developed a DNA vaccine encoding the receptor-binding domain (RBD) of PHEV spike protein fused to IgG1 Fc, adjuvante...

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Main Authors: Huabo Yu, Junchao Shi, Guoce Fu, Zezhao Cao, Ruizhao Qiu, Tianqi Zhao, Jing Zhang, Yungang Lan, Jiyu Guan, Kui Zhao, Feng Gao, Wenqi He, Zi Li
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01247-1
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https://doi.org/10.1038/s41541-025-01247-1

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