Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes
Aims. We aimed to investigate the sex differences in the renal function decline among patients with type 2 diabetic mellitus (T2DM), focusing on the differences in the risk factors at early stage of renal dysfunction. Methods. A clinic-based retrospective longitudinal study (follow-up duration: 8.1±...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/4626382 |
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| author | Ayami Kajiwara Ayana Kita Junji Saruwatari Hiroko Miyazaki Yuki Kawata Kazunori Morita Kentaro Oniki Akira Yoshida Hideaki Jinnouchi Kazuko Nakagawa |
| author_facet | Ayami Kajiwara Ayana Kita Junji Saruwatari Hiroko Miyazaki Yuki Kawata Kazunori Morita Kentaro Oniki Akira Yoshida Hideaki Jinnouchi Kazuko Nakagawa |
| author_sort | Ayami Kajiwara |
| collection | DOAJ |
| description | Aims. We aimed to investigate the sex differences in the renal function decline among patients with type 2 diabetic mellitus (T2DM), focusing on the differences in the risk factors at early stage of renal dysfunction. Methods. A clinic-based retrospective longitudinal study (follow-up duration: 8.1±1.4 years) was conducted to assess the sex differences in the annual estimated glomerular filtration rate (eGFR) change in 344 (247 male and 97 female) Japanese T2DM patients. The sex differences in the risk factors of annual eGFR decline were subjected to linear regression analyses. Results. The mean annual eGFR change was -3.5±2.7%/year in females and -2.0±2.2%/year in males (P<0.001). Baseline retinopathy and proteinuria were significantly associated with a larger eGFR decline, irrespective of sex, while HbA1c and LDL-cholesterol levels were significantly associated with an eGFR decline in females only. Interactive effects were observed between sex and the HbA1c, LDL-cholesterol, retinopathy, or proteinuria levels on the annual eGFR decline. Conclusions. The increased susceptibility to poor metabolic control seemed to contribute to a higher risk of renal dysfunction in females with T2DM. Our study highlights the importance of aggressive therapeutic intervention to improve metabolic profiles at early stage, especially in females. |
| format | Article |
| id | doaj-art-3c02fe2f49dd4a6885cbbad2f6549e2a |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-3c02fe2f49dd4a6885cbbad2f6549e2a2025-08-20T02:08:19ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/46263824626382Sex Differences in the Renal Function Decline of Patients with Type 2 DiabetesAyami Kajiwara0Ayana Kita1Junji Saruwatari2Hiroko Miyazaki3Yuki Kawata4Kazunori Morita5Kentaro Oniki6Akira Yoshida7Hideaki Jinnouchi8Kazuko Nakagawa9Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, JapanDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, JapanDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, JapanDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, JapanDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, JapanDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, JapanDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, JapanJinnouchi Clinic, Diabetes Care Center, 6-2-3 Kuhonji, Chuo-ku, Kumamoto 862-0976, JapanJinnouchi Clinic, Diabetes Care Center, 6-2-3 Kuhonji, Chuo-ku, Kumamoto 862-0976, JapanDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, JapanAims. We aimed to investigate the sex differences in the renal function decline among patients with type 2 diabetic mellitus (T2DM), focusing on the differences in the risk factors at early stage of renal dysfunction. Methods. A clinic-based retrospective longitudinal study (follow-up duration: 8.1±1.4 years) was conducted to assess the sex differences in the annual estimated glomerular filtration rate (eGFR) change in 344 (247 male and 97 female) Japanese T2DM patients. The sex differences in the risk factors of annual eGFR decline were subjected to linear regression analyses. Results. The mean annual eGFR change was -3.5±2.7%/year in females and -2.0±2.2%/year in males (P<0.001). Baseline retinopathy and proteinuria were significantly associated with a larger eGFR decline, irrespective of sex, while HbA1c and LDL-cholesterol levels were significantly associated with an eGFR decline in females only. Interactive effects were observed between sex and the HbA1c, LDL-cholesterol, retinopathy, or proteinuria levels on the annual eGFR decline. Conclusions. The increased susceptibility to poor metabolic control seemed to contribute to a higher risk of renal dysfunction in females with T2DM. Our study highlights the importance of aggressive therapeutic intervention to improve metabolic profiles at early stage, especially in females.http://dx.doi.org/10.1155/2016/4626382 |
| spellingShingle | Ayami Kajiwara Ayana Kita Junji Saruwatari Hiroko Miyazaki Yuki Kawata Kazunori Morita Kentaro Oniki Akira Yoshida Hideaki Jinnouchi Kazuko Nakagawa Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes Journal of Diabetes Research |
| title | Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes |
| title_full | Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes |
| title_fullStr | Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes |
| title_full_unstemmed | Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes |
| title_short | Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes |
| title_sort | sex differences in the renal function decline of patients with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2016/4626382 |
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