The role of EBV lytic genes in tumor development and progression
Epstein-Barr virus (EBV), the first human oncolytic virus, is the causative agent of several cancers of epithelial and lymphoid origin. The life cycle of EBV consists of two phases, the latent and lytic phases. The lytic cycle is the phase in which new virus particles are produced, whereas the laten...
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| Format: | Article |
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Editorial Office of Journal of Guangxi Medical University
2024-09-01
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| Series: | Guangxi Yike Daxue xuebao |
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| Online Access: | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.09.004 |
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| author | DENG Yizhang ZHONG Qian |
| author_facet | DENG Yizhang ZHONG Qian |
| author_sort | DENG Yizhang |
| collection | DOAJ |
| description | Epstein-Barr virus (EBV), the first human oncolytic virus, is the causative agent of several cancers of epithelial and lymphoid origin. The life cycle of EBV consists of two phases, the latent and lytic phases. The lytic cycle is the phase in which new virus particles are produced, whereas the latent cycle is a state of persistent infection that does not result in efficient viral replication. The current view is that latent-phase genes are key drivers of the pathogenesis of EBV-associated cancers, whereas lytic genes are primarily responsible for viral transmission. However, recent evidence suggests that the lytic phase of EBV also plays an important role in EBV tumorigenesis, and researchers have detected the expression of lytic genes in tumor tissues and cell lines. This paper will outline the contributory role of EBV lytic genes in tumorigenesis and discuss possible future research directions. |
| format | Article |
| id | doaj-art-3bfcc299bab147f9a613781d6372e542 |
| institution | DOAJ |
| issn | 1005-930X |
| language | zho |
| publishDate | 2024-09-01 |
| publisher | Editorial Office of Journal of Guangxi Medical University |
| record_format | Article |
| series | Guangxi Yike Daxue xuebao |
| spelling | doaj-art-3bfcc299bab147f9a613781d6372e5422025-08-20T02:57:28ZzhoEditorial Office of Journal of Guangxi Medical UniversityGuangxi Yike Daxue xuebao1005-930X2024-09-014191252126010.16190/j.cnki.45-1211/r.2024.09.004gxykdxxb-41-9-1252The role of EBV lytic genes in tumor development and progressionDENG Yizhang0ZHONG Qian1State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou 510060, ChinaState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou 510060, ChinaEpstein-Barr virus (EBV), the first human oncolytic virus, is the causative agent of several cancers of epithelial and lymphoid origin. The life cycle of EBV consists of two phases, the latent and lytic phases. The lytic cycle is the phase in which new virus particles are produced, whereas the latent cycle is a state of persistent infection that does not result in efficient viral replication. The current view is that latent-phase genes are key drivers of the pathogenesis of EBV-associated cancers, whereas lytic genes are primarily responsible for viral transmission. However, recent evidence suggests that the lytic phase of EBV also plays an important role in EBV tumorigenesis, and researchers have detected the expression of lytic genes in tumor tissues and cell lines. This paper will outline the contributory role of EBV lytic genes in tumorigenesis and discuss possible future research directions.https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.09.004epstein-barr virustumorlytic genes |
| spellingShingle | DENG Yizhang ZHONG Qian The role of EBV lytic genes in tumor development and progression Guangxi Yike Daxue xuebao epstein-barr virus tumor lytic genes |
| title | The role of EBV lytic genes in tumor development and progression |
| title_full | The role of EBV lytic genes in tumor development and progression |
| title_fullStr | The role of EBV lytic genes in tumor development and progression |
| title_full_unstemmed | The role of EBV lytic genes in tumor development and progression |
| title_short | The role of EBV lytic genes in tumor development and progression |
| title_sort | role of ebv lytic genes in tumor development and progression |
| topic | epstein-barr virus tumor lytic genes |
| url | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.09.004 |
| work_keys_str_mv | AT dengyizhang theroleofebvlyticgenesintumordevelopmentandprogression AT zhongqian theroleofebvlyticgenesintumordevelopmentandprogression AT dengyizhang roleofebvlyticgenesintumordevelopmentandprogression AT zhongqian roleofebvlyticgenesintumordevelopmentandprogression |