Conductometric, physico-chemical, and biological activity investigations of a copper–indometacin complex
Copper–indometacin (Cu-Indo) complex was prepared and X-ray diffraction, IR analysis, UV–V spectrophotometric analysis and thermal analysis of the formed (Cu-Indo) complex were used to characterize it. The formation constants for the complexation of CuCl2.2H2O and indometacin in methanol, ethanol, a...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Green Chemistry Letters and Reviews |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/17518253.2025.2455938 |
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| author | AbdulAziz A. Alayyafi Kholoud Z. Ghanem Modhi S. Almarri Shereen E. Salem Esam A. Gomaa Elsayed M. AbouElleef |
| author_facet | AbdulAziz A. Alayyafi Kholoud Z. Ghanem Modhi S. Almarri Shereen E. Salem Esam A. Gomaa Elsayed M. AbouElleef |
| author_sort | AbdulAziz A. Alayyafi |
| collection | DOAJ |
| description | Copper–indometacin (Cu-Indo) complex was prepared and X-ray diffraction, IR analysis, UV–V spectrophotometric analysis and thermal analysis of the formed (Cu-Indo) complex were used to characterize it. The formation constants for the complexation of CuCl2.2H2O and indometacin in methanol, ethanol, and their binary mixture with water were determined by the conductometric technique. Three stoichiometric complexes of copper–indometacin (1/2), (1/1), and (2/1) (M/L) were detected and their formation constants (Kf) were estimated by using the conductometric method and the Gibbs free energy change (ΔGf) was also estimated. The antimicrobial activities of indometacin and (Cu-Indo) complex have been studied using the disc diffusion method against Gram-negative bacteria (P. aeruginosa, E. coli, and K. pneumoniae), Gram-positive bacteria (S. aureus, B. cereus, and S. epidermidis), and fungi (C. albicans). In B. cereus, the (Cu-Indo) complex has a larger inhibitory zone (Gram-positive bacteria). As a result, it can be utilized to treat B. cereus bacteria (cytotoxicity testing was not conducted in this study). |
| format | Article |
| id | doaj-art-3bfb14c45e204df59125c594ad032b22 |
| institution | Kabale University |
| issn | 1751-8253 1751-7192 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Green Chemistry Letters and Reviews |
| spelling | doaj-art-3bfb14c45e204df59125c594ad032b222025-01-31T10:27:06ZengTaylor & Francis GroupGreen Chemistry Letters and Reviews1751-82531751-71922025-12-0118110.1080/17518253.2025.2455938Conductometric, physico-chemical, and biological activity investigations of a copper–indometacin complexAbdulAziz A. Alayyafi0Kholoud Z. Ghanem1Modhi S. Almarri2Shereen E. Salem3Esam A. Gomaa4Elsayed M. AbouElleef5Chemistry Department, Al-Qunfudhah University College, Umm Al-Qura University, Saudi ArabiaDepartment of Biological Science, College of Science & Humanities, Shaqra University, Riyadh, Saudi ArabiaDepartment of Science and Technology, University Colleges at Nairiyah, University of Hafr Al Batin, Nairiyah, Saudi ArabiaChemistry Department, Faculty of Science, Mansoura University, Mansoura, EgyptChemistry Department, Faculty of Science, Mansoura University, Mansoura, EgyptBasic Sciences Department, Delta Higher Institute for Engineering and Technology, Mansoura, EgyptCopper–indometacin (Cu-Indo) complex was prepared and X-ray diffraction, IR analysis, UV–V spectrophotometric analysis and thermal analysis of the formed (Cu-Indo) complex were used to characterize it. The formation constants for the complexation of CuCl2.2H2O and indometacin in methanol, ethanol, and their binary mixture with water were determined by the conductometric technique. Three stoichiometric complexes of copper–indometacin (1/2), (1/1), and (2/1) (M/L) were detected and their formation constants (Kf) were estimated by using the conductometric method and the Gibbs free energy change (ΔGf) was also estimated. The antimicrobial activities of indometacin and (Cu-Indo) complex have been studied using the disc diffusion method against Gram-negative bacteria (P. aeruginosa, E. coli, and K. pneumoniae), Gram-positive bacteria (S. aureus, B. cereus, and S. epidermidis), and fungi (C. albicans). In B. cereus, the (Cu-Indo) complex has a larger inhibitory zone (Gram-positive bacteria). As a result, it can be utilized to treat B. cereus bacteria (cytotoxicity testing was not conducted in this study).https://www.tandfonline.com/doi/10.1080/17518253.2025.2455938Indometacincopper chloridecomplexconductivityantimicrobial activities |
| spellingShingle | AbdulAziz A. Alayyafi Kholoud Z. Ghanem Modhi S. Almarri Shereen E. Salem Esam A. Gomaa Elsayed M. AbouElleef Conductometric, physico-chemical, and biological activity investigations of a copper–indometacin complex Green Chemistry Letters and Reviews Indometacin copper chloride complex conductivity antimicrobial activities |
| title | Conductometric, physico-chemical, and biological activity investigations of a copper–indometacin complex |
| title_full | Conductometric, physico-chemical, and biological activity investigations of a copper–indometacin complex |
| title_fullStr | Conductometric, physico-chemical, and biological activity investigations of a copper–indometacin complex |
| title_full_unstemmed | Conductometric, physico-chemical, and biological activity investigations of a copper–indometacin complex |
| title_short | Conductometric, physico-chemical, and biological activity investigations of a copper–indometacin complex |
| title_sort | conductometric physico chemical and biological activity investigations of a copper indometacin complex |
| topic | Indometacin copper chloride complex conductivity antimicrobial activities |
| url | https://www.tandfonline.com/doi/10.1080/17518253.2025.2455938 |
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