THE FACTORS THAT AFFECT STAPHYLOCCUS AUREUS CELL WALL SYNTHESIS AND RESISTANCE TO ACTINOMYCIN D
The cells of the strain S.aureus R80 strain, resistant to actinomycin D, possess a cell wall, thickened as a result of additional synthesis of peptidoglycan. Addition of D-serine or D-threonine to the environment modify the precursors of peptidoglycan and significantly decreases the strain R80 strai...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC "Publishing House OKI"
2020-05-01
|
| Series: | Антибиотики и Химиотерапия |
| Subjects: | |
| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | The cells of the strain S.aureus R80 strain, resistant to actinomycin D, possess a cell wall, thickened as a result of additional synthesis of peptidoglycan. Addition of D-serine or D-threonine to the environment modify the precursors of peptidoglycan and significantly decreases the strain R80 strain resistance to actinomycin D. Subingibitory concentrations of an antibiotic tunicamycin - effective inhibitor of synthesis of wall teichoic acids S.aureus - do not affect the growth of microorganism but produce a significant increase of sensitivity of the strain R80 strain to actinomycin D. The modification of the composition of peptidoglycan by D-aminoacids as well as the inhibition of the synthesis of wall teichoic acids are likely to increase permeability of a cell wall of the resistant strain S.aureus R80 strain for actinomycin D. |
|---|---|
| ISSN: | 0235-2990 |