Dopamine and norepinephrine role in alcohol-addictive behavior: from correlations to mechanisms
Using animal models that translate key features of alcohol dependence, the field has faced remarkable achievements in identifying neurochemical substrates of this disease with dopamine and norepinephrine playing significant role. Moreover, recent utilization of optogenetics in alcohol research provi...
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| Format: | Article |
| Language: | Russian |
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Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2022-10-01
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| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
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| Online Access: | https://www.bekhterevreview.com/jour/article/view/716 |
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| author | V. P. Grinevich V. V. Nemets E. M. Krupitsky R. R. Gainetdinov E. A. Budygin |
| author_facet | V. P. Grinevich V. V. Nemets E. M. Krupitsky R. R. Gainetdinov E. A. Budygin |
| author_sort | V. P. Grinevich |
| collection | DOAJ |
| description | Using animal models that translate key features of alcohol dependence, the field has faced remarkable achievements in identifying neurochemical substrates of this disease with dopamine and norepinephrine playing significant role. Moreover, recent utilization of optogenetics in alcohol research provides with an opportunity in specifying patterns of neurotransmission within dopaminergic and noradrenergic neural circuits that govern ethanol-addictive behavior. This review summarizes experimental findings to demonstrate the effectiveness of the latest technologies in revealing the mechanisms bridging catecholamines’ specific changes with alcohol seeking, consummatory and relapsing behaviors. |
| format | Article |
| id | doaj-art-3bf02fc8f74745bb87b6102a6aa130d3 |
| institution | Kabale University |
| issn | 2313-7053 2713-055X |
| language | Russian |
| publishDate | 2022-10-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj-art-3bf02fc8f74745bb87b6102a6aa130d32025-08-20T03:42:06ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2022-10-01563132910.31363/2313-7053-2022-56-3-13-29450Dopamine and norepinephrine role in alcohol-addictive behavior: from correlations to mechanismsV. P. Grinevich0V. V. Nemets1E. M. Krupitsky2R. R. Gainetdinov3E. A. Budygin4Sirius University of Science and Technology, FD SiriusSt. Petersburg State UniversityV.M. Bekhterev National Medical Research Center for Psychiatry and Neurology; St.-Petersburg First Pavlov State Medical UniversitySirius University of Science and Technology, FD Sirius; St. Petersburg State UniversitySirius University of Science and Technology, FD SiriusUsing animal models that translate key features of alcohol dependence, the field has faced remarkable achievements in identifying neurochemical substrates of this disease with dopamine and norepinephrine playing significant role. Moreover, recent utilization of optogenetics in alcohol research provides with an opportunity in specifying patterns of neurotransmission within dopaminergic and noradrenergic neural circuits that govern ethanol-addictive behavior. This review summarizes experimental findings to demonstrate the effectiveness of the latest technologies in revealing the mechanisms bridging catecholamines’ specific changes with alcohol seeking, consummatory and relapsing behaviors.https://www.bekhterevreview.com/jour/article/view/716ethanolalcohol dependencebehaviordopaminenorepinephrinevoltammetryoptogenetics |
| spellingShingle | V. P. Grinevich V. V. Nemets E. M. Krupitsky R. R. Gainetdinov E. A. Budygin Dopamine and norepinephrine role in alcohol-addictive behavior: from correlations to mechanisms Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева ethanol alcohol dependence behavior dopamine norepinephrine voltammetry optogenetics |
| title | Dopamine and norepinephrine role in alcohol-addictive behavior: from correlations to mechanisms |
| title_full | Dopamine and norepinephrine role in alcohol-addictive behavior: from correlations to mechanisms |
| title_fullStr | Dopamine and norepinephrine role in alcohol-addictive behavior: from correlations to mechanisms |
| title_full_unstemmed | Dopamine and norepinephrine role in alcohol-addictive behavior: from correlations to mechanisms |
| title_short | Dopamine and norepinephrine role in alcohol-addictive behavior: from correlations to mechanisms |
| title_sort | dopamine and norepinephrine role in alcohol addictive behavior from correlations to mechanisms |
| topic | ethanol alcohol dependence behavior dopamine norepinephrine voltammetry optogenetics |
| url | https://www.bekhterevreview.com/jour/article/view/716 |
| work_keys_str_mv | AT vpgrinevich dopamineandnorepinephrineroleinalcoholaddictivebehaviorfromcorrelationstomechanisms AT vvnemets dopamineandnorepinephrineroleinalcoholaddictivebehaviorfromcorrelationstomechanisms AT emkrupitsky dopamineandnorepinephrineroleinalcoholaddictivebehaviorfromcorrelationstomechanisms AT rrgainetdinov dopamineandnorepinephrineroleinalcoholaddictivebehaviorfromcorrelationstomechanisms AT eabudygin dopamineandnorepinephrineroleinalcoholaddictivebehaviorfromcorrelationstomechanisms |