Dosimetric and clinical outcomes study of occult uterine tandem imperfect implantation in HDR-brachytherapy for cervical cancer
Abstract To investigate the ramifications of dose alterations and clinical outcomes linked to imperfect uterine tandem implantation within high dose rate brachytherapy (HDR-brachytherapy) for cervical cancer. A retrospective analysis was conducted on imperfect intrauterine insertion images from Nove...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-02779-1 |
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| author | Xiujuan Zhao Haiyan Wu Ruotong Yi Duke Chen Ying Tang Qi Zhou Dongling Zou |
| author_facet | Xiujuan Zhao Haiyan Wu Ruotong Yi Duke Chen Ying Tang Qi Zhou Dongling Zou |
| author_sort | Xiujuan Zhao |
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| description | Abstract To investigate the ramifications of dose alterations and clinical outcomes linked to imperfect uterine tandem implantation within high dose rate brachytherapy (HDR-brachytherapy) for cervical cancer. A retrospective analysis was conducted on imperfect intrauterine insertion images from November 2020 to July 2021. The physicist reconfigured two-dimensions (2D) and three-dimensions (3D) plans based on prescription (6 Gy) for both the imperfection (IM) and perfect (PER) implantation. A paired t-test was employed to assess (reference volume of clinical target volume) CTVref, (reference isodose) Vref, (conformal index) COIN, (equivalent dose in 2-Gy fractions) EQD2 of (organs at risks) OARs, (tumor control probability) TCP, and (normal tissue complication probability) NTCP. Among 1742 brachytherapy insertions, 38 (2.18%) instances of imperfect images were identified in 24 out of 319 patients (7.52%). COIN > 0.64 met the prescribed requirements solely in the PER-3D group. For inadequate implantation, the IM-3D-group showed enhancements in EQD2 of OARs and NTCP for the rectum, sigmoid colon, and small intestine, whereas NTCP of the bladder was augmented in the IM-2D-group. Regarding anterior wall perforation, the IM-group exhibited increases in EQD2 and NTCP for the rectum and small intestine, along with EQD2 for the bladder in 3D. In the IM-2D-group demonstrated increases in EQD2 for the bladder, rectum, and small intestine, as well as NTCP for the sigmoid and small intestine. In cases of posterior wall perforation, the IM-3D-group showcased augmented EQD2 for the bladder and rectum, and NTCP for the rectum and sigmoid. Conversely, EQD2 was solely increased in the rectum in the 2D context. Finally, in instances of fundus perforation, the IM-group exhibited heightened EQD2 for the sigmoid. Imperfect uterine tube implantation leads to worse clinical outcomes and greater adverse reactions. |
| format | Article |
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| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-3beedb9308c8455db58e9c4091dd5d712025-08-20T03:04:25ZengNature PortfolioScientific Reports2045-23222025-07-0115111110.1038/s41598-025-02779-1Dosimetric and clinical outcomes study of occult uterine tandem imperfect implantation in HDR-brachytherapy for cervical cancerXiujuan Zhao0Haiyan Wu1Ruotong Yi2Duke Chen3Ying Tang4Qi Zhou5Dongling Zou6Department Of Gynecology Oncology Center, Chongqing University Cancer HospitalDepartment Of Gynecology Oncology Center, Chongqing University Cancer HospitalDepartment of Publicity and Health Education, Chongqing University Cancer HospitalDepartment Of Gynecology Oncology Center, Chongqing University Cancer HospitalDepartment Of Gynecology Oncology Center, Chongqing University Cancer HospitalDepartment Of Gynecology Oncology Center, Chongqing University Cancer HospitalDepartment Of Gynecology Oncology Center, Chongqing University Cancer HospitalAbstract To investigate the ramifications of dose alterations and clinical outcomes linked to imperfect uterine tandem implantation within high dose rate brachytherapy (HDR-brachytherapy) for cervical cancer. A retrospective analysis was conducted on imperfect intrauterine insertion images from November 2020 to July 2021. The physicist reconfigured two-dimensions (2D) and three-dimensions (3D) plans based on prescription (6 Gy) for both the imperfection (IM) and perfect (PER) implantation. A paired t-test was employed to assess (reference volume of clinical target volume) CTVref, (reference isodose) Vref, (conformal index) COIN, (equivalent dose in 2-Gy fractions) EQD2 of (organs at risks) OARs, (tumor control probability) TCP, and (normal tissue complication probability) NTCP. Among 1742 brachytherapy insertions, 38 (2.18%) instances of imperfect images were identified in 24 out of 319 patients (7.52%). COIN > 0.64 met the prescribed requirements solely in the PER-3D group. For inadequate implantation, the IM-3D-group showed enhancements in EQD2 of OARs and NTCP for the rectum, sigmoid colon, and small intestine, whereas NTCP of the bladder was augmented in the IM-2D-group. Regarding anterior wall perforation, the IM-group exhibited increases in EQD2 and NTCP for the rectum and small intestine, along with EQD2 for the bladder in 3D. In the IM-2D-group demonstrated increases in EQD2 for the bladder, rectum, and small intestine, as well as NTCP for the sigmoid and small intestine. In cases of posterior wall perforation, the IM-3D-group showcased augmented EQD2 for the bladder and rectum, and NTCP for the rectum and sigmoid. Conversely, EQD2 was solely increased in the rectum in the 2D context. Finally, in instances of fundus perforation, the IM-group exhibited heightened EQD2 for the sigmoid. Imperfect uterine tube implantation leads to worse clinical outcomes and greater adverse reactions.https://doi.org/10.1038/s41598-025-02779-1HDR-brachytherapyCervical cancerUterine tandemImperfect implantation |
| spellingShingle | Xiujuan Zhao Haiyan Wu Ruotong Yi Duke Chen Ying Tang Qi Zhou Dongling Zou Dosimetric and clinical outcomes study of occult uterine tandem imperfect implantation in HDR-brachytherapy for cervical cancer Scientific Reports HDR-brachytherapy Cervical cancer Uterine tandem Imperfect implantation |
| title | Dosimetric and clinical outcomes study of occult uterine tandem imperfect implantation in HDR-brachytherapy for cervical cancer |
| title_full | Dosimetric and clinical outcomes study of occult uterine tandem imperfect implantation in HDR-brachytherapy for cervical cancer |
| title_fullStr | Dosimetric and clinical outcomes study of occult uterine tandem imperfect implantation in HDR-brachytherapy for cervical cancer |
| title_full_unstemmed | Dosimetric and clinical outcomes study of occult uterine tandem imperfect implantation in HDR-brachytherapy for cervical cancer |
| title_short | Dosimetric and clinical outcomes study of occult uterine tandem imperfect implantation in HDR-brachytherapy for cervical cancer |
| title_sort | dosimetric and clinical outcomes study of occult uterine tandem imperfect implantation in hdr brachytherapy for cervical cancer |
| topic | HDR-brachytherapy Cervical cancer Uterine tandem Imperfect implantation |
| url | https://doi.org/10.1038/s41598-025-02779-1 |
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