Peptidoglycan and Bacterial DNA Induce Inflammation and Coagulation Markers in Synergy
Bacterial compounds signal the presence of foreign pathogens in the innate immune system. These microbial components are key players in infectious diseases and implicate toll-like receptors in the activation of inflammation and coagulation. Nevertheless, the existence of a synergistic relationship b...
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI.2005.118 |
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| author | Marie-Claude Amoureux Nandani Rajapakse Lazlo Stipkovits Susan Szathmary |
| author_facet | Marie-Claude Amoureux Nandani Rajapakse Lazlo Stipkovits Susan Szathmary |
| author_sort | Marie-Claude Amoureux |
| collection | DOAJ |
| description | Bacterial compounds signal the presence of foreign pathogens in the innate immune system. These microbial components are key players in infectious diseases and implicate toll-like receptors in the activation of inflammation and coagulation. Nevertheless, the existence of a synergistic relationship between peptidoglycan and bacterial DNA on these two physiological responses has not been investigated. The present study reports new
findings on the regulation of tumor necrosis factor alpha and tissue factor in peripheral blood mononuclear cells by peptidoglycan and bacterial DNA. These were found to induce tumor necrosis factor alpha and tissue factor simultaneously and in a synergistic manner. These findings provide a new proinflammatory and procoagulant mechanism likely to play a role in sepsis pathogenesis. |
| format | Article |
| id | doaj-art-3beba28bd82546ac97763c0e5613aab0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3beba28bd82546ac97763c0e5613aab02025-02-03T01:21:43ZengWileyMediators of Inflammation0962-93511466-18612005-01-012005211812010.1155/MI.2005.118Peptidoglycan and Bacterial DNA Induce Inflammation and Coagulation Markers in SynergyMarie-Claude Amoureux0Nandani Rajapakse1Lazlo Stipkovits2Susan Szathmary3Clarigen Inc, 5922 Farnsworth Court, Carlsbad, CA 92008, USAClarigen Inc, 5922 Farnsworth Court, Carlsbad, CA 92008, USAHungarian Academy of Sciences, Veterinary Medical Research Institute, 1143 Budapest, Hungaria krt 21, HungaryClarigen Inc, 5922 Farnsworth Court, Carlsbad, CA 92008, USABacterial compounds signal the presence of foreign pathogens in the innate immune system. These microbial components are key players in infectious diseases and implicate toll-like receptors in the activation of inflammation and coagulation. Nevertheless, the existence of a synergistic relationship between peptidoglycan and bacterial DNA on these two physiological responses has not been investigated. The present study reports new findings on the regulation of tumor necrosis factor alpha and tissue factor in peripheral blood mononuclear cells by peptidoglycan and bacterial DNA. These were found to induce tumor necrosis factor alpha and tissue factor simultaneously and in a synergistic manner. These findings provide a new proinflammatory and procoagulant mechanism likely to play a role in sepsis pathogenesis.http://dx.doi.org/10.1155/MI.2005.118 |
| spellingShingle | Marie-Claude Amoureux Nandani Rajapakse Lazlo Stipkovits Susan Szathmary Peptidoglycan and Bacterial DNA Induce Inflammation and Coagulation Markers in Synergy Mediators of Inflammation |
| title | Peptidoglycan and Bacterial DNA Induce Inflammation and Coagulation Markers in Synergy |
| title_full | Peptidoglycan and Bacterial DNA Induce Inflammation and Coagulation Markers in Synergy |
| title_fullStr | Peptidoglycan and Bacterial DNA Induce Inflammation and Coagulation Markers in Synergy |
| title_full_unstemmed | Peptidoglycan and Bacterial DNA Induce Inflammation and Coagulation Markers in Synergy |
| title_short | Peptidoglycan and Bacterial DNA Induce Inflammation and Coagulation Markers in Synergy |
| title_sort | peptidoglycan and bacterial dna induce inflammation and coagulation markers in synergy |
| url | http://dx.doi.org/10.1155/MI.2005.118 |
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