Self-Expanding Metal Stenting for Palliation of Patients with Malignant Colonic Obstruction: Effectiveness and Efficacy on 255 Patients with 12-Month's Follow-up
Background. Self-expanding metal stents can alleviate malignant colonic obstruction in incurable patients and avoid palliative stoma surgery. Objective. Evaluate stent effectiveness and safety on palliation of patients with malignant colorectal strictures. Design. Two prospective, one Spanish and on...
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| Format: | Article |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/296347 |
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| author | Søren Meisner Ferran González-Huix Jo G. Vandervoort Alessandro Repici Dimitrios Xinopoulos Karl E. Grund Paul Goldberg The WallFlex Colonic Registry Group |
| author_facet | Søren Meisner Ferran González-Huix Jo G. Vandervoort Alessandro Repici Dimitrios Xinopoulos Karl E. Grund Paul Goldberg The WallFlex Colonic Registry Group |
| author_sort | Søren Meisner |
| collection | DOAJ |
| description | Background. Self-expanding metal stents can alleviate malignant colonic obstruction in incurable patients and avoid palliative stoma surgery. Objective. Evaluate stent effectiveness and safety on palliation of patients with malignant colorectal strictures. Design. Two prospective, one Spanish and one global, multicenter studies. Settings. 39 centers (22 academic, 17 community hospitals) from 13 countries. Patients. A total of 257 patients were enrolled, and 255 patients were treated with a WallFlex uncovered enteral colonic stent. Follow-up was up to 12 months or until death or retreatment. Interventions(s). Self-expanding metal stent placement. Main Outcome Measures. Procedural success, clinical success, and safety. Results. Procedural success was 98.4% (251). Clinical success rates were 87.8% at 30 days, 89.7% at 3 months, 92.8% at 6 months, and 96% at 12 months. Overall perforation rate was 5.1%. Overall migration rate was 5.5%. Overall death rate during follow-up was 48.6% (124), with 67.7% of deaths related to the patient’s colorectal cancer, unrelated in 32.3%. Only 2 deaths were related to the stent or procedure. Limitations. No control group. Conclusions. The primary palliative option for patients with malignant colonic obstruction should be self-expanding metal stent placement due to high rates of technical success and efficacy in symptom palliation and few complications. |
| format | Article |
| id | doaj-art-3beb463839dd433a97ea18c952ff061c |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | Gastroenterology Research and Practice |
| spelling | doaj-art-3beb463839dd433a97ea18c952ff061c2025-08-20T03:55:41ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/296347296347Self-Expanding Metal Stenting for Palliation of Patients with Malignant Colonic Obstruction: Effectiveness and Efficacy on 255 Patients with 12-Month's Follow-upSøren Meisner0Ferran González-Huix1Jo G. Vandervoort2Alessandro Repici3Dimitrios Xinopoulos4Karl E. Grund5Paul Goldberg6The WallFlex Colonic Registry Group7Endoscopy Unit, Bispebjerg Hospital, Bispebjerg Bakke 23, Entrance 7B, 2400 Copenhagen NV, DenmarkUnidad de Endoscopia, Servicio de Aparato Digestivo, Hospital Doctor Josep Trueta, Carretera Franca s/n, Catalunya, 17007 Girona, SpainGastro-enterologie, Onze Lieve Vrouw Ziekenhuis, Moorselbaan 164, 9300 Aalst, BelgiumDepartment of Digestive Endoscopy, Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, ItalyGastroenterology Unit, Saint Savas Hospital, 171 Alexadras Avenue, 11522 Athens, GreeceDepartment of Surgical Endoscopy, University Hospital Tuebingen, Geissweg 3, 72076 Tuebingen, GermanyDepartment-Colorectal Surgery, Groote Schuur Hospital, Private Bag, Observatory, Cape Town 7937, South AfricaWallFlex Enteral Colonic Stent for Relieving Malignant Colorectal Obstruction, Boston Scientific, Natick, MA 01760, USABackground. Self-expanding metal stents can alleviate malignant colonic obstruction in incurable patients and avoid palliative stoma surgery. Objective. Evaluate stent effectiveness and safety on palliation of patients with malignant colorectal strictures. Design. Two prospective, one Spanish and one global, multicenter studies. Settings. 39 centers (22 academic, 17 community hospitals) from 13 countries. Patients. A total of 257 patients were enrolled, and 255 patients were treated with a WallFlex uncovered enteral colonic stent. Follow-up was up to 12 months or until death or retreatment. Interventions(s). Self-expanding metal stent placement. Main Outcome Measures. Procedural success, clinical success, and safety. Results. Procedural success was 98.4% (251). Clinical success rates were 87.8% at 30 days, 89.7% at 3 months, 92.8% at 6 months, and 96% at 12 months. Overall perforation rate was 5.1%. Overall migration rate was 5.5%. Overall death rate during follow-up was 48.6% (124), with 67.7% of deaths related to the patient’s colorectal cancer, unrelated in 32.3%. Only 2 deaths were related to the stent or procedure. Limitations. No control group. Conclusions. The primary palliative option for patients with malignant colonic obstruction should be self-expanding metal stent placement due to high rates of technical success and efficacy in symptom palliation and few complications.http://dx.doi.org/10.1155/2012/296347 |
| spellingShingle | Søren Meisner Ferran González-Huix Jo G. Vandervoort Alessandro Repici Dimitrios Xinopoulos Karl E. Grund Paul Goldberg The WallFlex Colonic Registry Group Self-Expanding Metal Stenting for Palliation of Patients with Malignant Colonic Obstruction: Effectiveness and Efficacy on 255 Patients with 12-Month's Follow-up Gastroenterology Research and Practice |
| title | Self-Expanding Metal Stenting for Palliation of Patients with Malignant Colonic Obstruction: Effectiveness and Efficacy on 255 Patients with 12-Month's Follow-up |
| title_full | Self-Expanding Metal Stenting for Palliation of Patients with Malignant Colonic Obstruction: Effectiveness and Efficacy on 255 Patients with 12-Month's Follow-up |
| title_fullStr | Self-Expanding Metal Stenting for Palliation of Patients with Malignant Colonic Obstruction: Effectiveness and Efficacy on 255 Patients with 12-Month's Follow-up |
| title_full_unstemmed | Self-Expanding Metal Stenting for Palliation of Patients with Malignant Colonic Obstruction: Effectiveness and Efficacy on 255 Patients with 12-Month's Follow-up |
| title_short | Self-Expanding Metal Stenting for Palliation of Patients with Malignant Colonic Obstruction: Effectiveness and Efficacy on 255 Patients with 12-Month's Follow-up |
| title_sort | self expanding metal stenting for palliation of patients with malignant colonic obstruction effectiveness and efficacy on 255 patients with 12 month s follow up |
| url | http://dx.doi.org/10.1155/2012/296347 |
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