The spatial biology of HIV infection.
HIV infection implicates a spectrum of tissues in the human body starting with viral transmission in the anogenital tract and subsequently persisting in lymphoid tissues and brain. Though studies using isolated cells have contributed significantly towards our understanding of HIV infection, the tiss...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1012888 |
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| _version_ | 1849723372840157184 |
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| author | Kevin Hu Thomas R O'Neil Heeva Baharlou Paul J Austin Jackson F Karrasch Lara Sarkawt Yuchen Li Kirstie M Bertram Anthony L Cunningham Ellis Patrick Andrew N Harman |
| author_facet | Kevin Hu Thomas R O'Neil Heeva Baharlou Paul J Austin Jackson F Karrasch Lara Sarkawt Yuchen Li Kirstie M Bertram Anthony L Cunningham Ellis Patrick Andrew N Harman |
| author_sort | Kevin Hu |
| collection | DOAJ |
| description | HIV infection implicates a spectrum of tissues in the human body starting with viral transmission in the anogenital tract and subsequently persisting in lymphoid tissues and brain. Though studies using isolated cells have contributed significantly towards our understanding of HIV infection, the tissue microenvironment is characterised by a complex interplay of a range of factors, all of which can influence the course of infection but are otherwise missed in ex vivo studies. To address this knowledge gap, it is necessary to investigate the dynamics of infection and the host immune response in situ using imaging-based approaches. Over the last decade, emerging imaging techniques have continually redefined the limits of detection, both in terms of the scope and the scale of the targets. In doing so, this has opened up new questions that can be answered by in situ studies. This review discusses the high-dimensional imaging modalities that are now available and their application towards understanding the spatial biology of HIV infection. |
| format | Article |
| id | doaj-art-3be30e1d67b449e9a1edbd0be712a790 |
| institution | DOAJ |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-3be30e1d67b449e9a1edbd0be712a7902025-08-20T03:11:03ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742025-01-01211e101288810.1371/journal.ppat.1012888The spatial biology of HIV infection.Kevin HuThomas R O'NeilHeeva BaharlouPaul J AustinJackson F KarraschLara SarkawtYuchen LiKirstie M BertramAnthony L CunninghamEllis PatrickAndrew N HarmanHIV infection implicates a spectrum of tissues in the human body starting with viral transmission in the anogenital tract and subsequently persisting in lymphoid tissues and brain. Though studies using isolated cells have contributed significantly towards our understanding of HIV infection, the tissue microenvironment is characterised by a complex interplay of a range of factors, all of which can influence the course of infection but are otherwise missed in ex vivo studies. To address this knowledge gap, it is necessary to investigate the dynamics of infection and the host immune response in situ using imaging-based approaches. Over the last decade, emerging imaging techniques have continually redefined the limits of detection, both in terms of the scope and the scale of the targets. In doing so, this has opened up new questions that can be answered by in situ studies. This review discusses the high-dimensional imaging modalities that are now available and their application towards understanding the spatial biology of HIV infection.https://doi.org/10.1371/journal.ppat.1012888 |
| spellingShingle | Kevin Hu Thomas R O'Neil Heeva Baharlou Paul J Austin Jackson F Karrasch Lara Sarkawt Yuchen Li Kirstie M Bertram Anthony L Cunningham Ellis Patrick Andrew N Harman The spatial biology of HIV infection. PLoS Pathogens |
| title | The spatial biology of HIV infection. |
| title_full | The spatial biology of HIV infection. |
| title_fullStr | The spatial biology of HIV infection. |
| title_full_unstemmed | The spatial biology of HIV infection. |
| title_short | The spatial biology of HIV infection. |
| title_sort | spatial biology of hiv infection |
| url | https://doi.org/10.1371/journal.ppat.1012888 |
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