Polyamine and Isoamylamine Levels in Peripheral Blood Cells and Plasma as Biomarkers of Structural and Functional Alterations in Acute Myocardial Infarction and Chronic Heart Failure Patients
Polyamines are essential biological compounds that play crucial roles in various physiological processes, including cardiovascular function. This study explored polyamine levels in peripheral blood cells and plasma from patients with acute myocardial infarction (AMI) and chronic heart failure (CHF),...
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2025-06-01
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| author | José Manuel Rubín Lorena Suárez Begoña Cantabrana Eva Barreiro-Alonso Ignacio Rodríguez-Uña Manuel Sánchez |
| author_facet | José Manuel Rubín Lorena Suárez Begoña Cantabrana Eva Barreiro-Alonso Ignacio Rodríguez-Uña Manuel Sánchez |
| author_sort | José Manuel Rubín |
| collection | DOAJ |
| description | Polyamines are essential biological compounds that play crucial roles in various physiological processes, including cardiovascular function. This study explored polyamine levels in peripheral blood cells and plasma from patients with acute myocardial infarction (AMI) and chronic heart failure (CHF), aiming to assess their value as biomarkers for cardiac diseases. A total of 129 individuals participated, comprising healthy controls and patients diagnosed with AMI or CHF. Polyamine concentrations were measured and analysed alongside standard clinical and biochemical markers of cardiac diseases. The results showed distinct patterns of polyamine alteration in AMI patients; putrescine levels were reduced in mononuclear cells, while isoamylamine levels were elevated in erythrocytes and plasma. In contrast, CHF patients had consistently low levels of all measured polyamines in erythrocytes and plasma, accompanied by high isoamylamine levels. Statistical analyses revealed significant correlations between polyamine levels and clinical indicators such as left ventricular ejection fraction, diastolic blood pressure, and troponin. Discriminant function analysis effectively distinguished between the control, AMI, and CHF groups based on their polyamine profiles. These findings suggest that an altered polyamine metabolism is associated with cardiovascular disease and support the potential of blood polyamine profiling as a non-invasive diagnostic and monitoring tool. Further research is warranted. |
| format | Article |
| id | doaj-art-3be23d48e46643e097eea67c2a2fa3f6 |
| institution | Kabale University |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Applied Sciences |
| spelling | doaj-art-3be23d48e46643e097eea67c2a2fa3f62025-08-20T03:26:10ZengMDPI AGApplied Sciences2076-34172025-06-011512645610.3390/app15126456Polyamine and Isoamylamine Levels in Peripheral Blood Cells and Plasma as Biomarkers of Structural and Functional Alterations in Acute Myocardial Infarction and Chronic Heart Failure PatientsJosé Manuel Rubín0Lorena Suárez1Begoña Cantabrana2Eva Barreiro-Alonso3Ignacio Rodríguez-Uña4Manuel Sánchez5Servicio de Cardiología, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, SpainInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, SpainInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, SpainInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, SpainInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, SpainInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, SpainPolyamines are essential biological compounds that play crucial roles in various physiological processes, including cardiovascular function. This study explored polyamine levels in peripheral blood cells and plasma from patients with acute myocardial infarction (AMI) and chronic heart failure (CHF), aiming to assess their value as biomarkers for cardiac diseases. A total of 129 individuals participated, comprising healthy controls and patients diagnosed with AMI or CHF. Polyamine concentrations were measured and analysed alongside standard clinical and biochemical markers of cardiac diseases. The results showed distinct patterns of polyamine alteration in AMI patients; putrescine levels were reduced in mononuclear cells, while isoamylamine levels were elevated in erythrocytes and plasma. In contrast, CHF patients had consistently low levels of all measured polyamines in erythrocytes and plasma, accompanied by high isoamylamine levels. Statistical analyses revealed significant correlations between polyamine levels and clinical indicators such as left ventricular ejection fraction, diastolic blood pressure, and troponin. Discriminant function analysis effectively distinguished between the control, AMI, and CHF groups based on their polyamine profiles. These findings suggest that an altered polyamine metabolism is associated with cardiovascular disease and support the potential of blood polyamine profiling as a non-invasive diagnostic and monitoring tool. Further research is warranted.https://www.mdpi.com/2076-3417/15/12/6456polyaminesputrescinespermidinespermineisoamylamineacute coronary syndrome |
| spellingShingle | José Manuel Rubín Lorena Suárez Begoña Cantabrana Eva Barreiro-Alonso Ignacio Rodríguez-Uña Manuel Sánchez Polyamine and Isoamylamine Levels in Peripheral Blood Cells and Plasma as Biomarkers of Structural and Functional Alterations in Acute Myocardial Infarction and Chronic Heart Failure Patients Applied Sciences polyamines putrescine spermidine spermine isoamylamine acute coronary syndrome |
| title | Polyamine and Isoamylamine Levels in Peripheral Blood Cells and Plasma as Biomarkers of Structural and Functional Alterations in Acute Myocardial Infarction and Chronic Heart Failure Patients |
| title_full | Polyamine and Isoamylamine Levels in Peripheral Blood Cells and Plasma as Biomarkers of Structural and Functional Alterations in Acute Myocardial Infarction and Chronic Heart Failure Patients |
| title_fullStr | Polyamine and Isoamylamine Levels in Peripheral Blood Cells and Plasma as Biomarkers of Structural and Functional Alterations in Acute Myocardial Infarction and Chronic Heart Failure Patients |
| title_full_unstemmed | Polyamine and Isoamylamine Levels in Peripheral Blood Cells and Plasma as Biomarkers of Structural and Functional Alterations in Acute Myocardial Infarction and Chronic Heart Failure Patients |
| title_short | Polyamine and Isoamylamine Levels in Peripheral Blood Cells and Plasma as Biomarkers of Structural and Functional Alterations in Acute Myocardial Infarction and Chronic Heart Failure Patients |
| title_sort | polyamine and isoamylamine levels in peripheral blood cells and plasma as biomarkers of structural and functional alterations in acute myocardial infarction and chronic heart failure patients |
| topic | polyamines putrescine spermidine spermine isoamylamine acute coronary syndrome |
| url | https://www.mdpi.com/2076-3417/15/12/6456 |
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