Engineered transcription-associated Cas9 targeting in eukaryotic cells

Engineered transcription-associated Cas9 targeting in eukaryotic cells

Abstract DNA targeting Class 2 CRISPR-Cas effector nucleases, including the well-studied Cas9 proteins, evolved protospacer-adjacent motif (PAM) and guide RNA interactions that sequentially license their binding and cleavage activities at protospacer target sites. Both interactions are nucleic acid...

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Main Authors: Gregory W. Goldberg, Manjunatha Kogenaru, Sarah Keegan, Max A. B. Haase, Larisa Kagermazova, Mauricio A. Arias, Kenenna Onyebeke, Samantha Adams, Daniel K. Beyer, David Fenyö, Marcus B. Noyes, Jef D. Boeke
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54629-9
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