The Effect of Combined Aerobic-Resistance Exercise on Interleukin-10 Levels, Vascular Endothelial Growth Factor, Neutrophil-to-Lymphocyte Ratio, Cognitive and Walking Functions in Obese Elderly Men
Background and purpose: Aging is a complex process characterized by multiple cellular and molecular disorders, gradually leading to a decline in physiological and cognitive functions. In this context, the prevalence of obesity, a key factor that exacerbates these issues, is increasing. This study ai...
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Mazandaran University of Medical Sciences
2025-03-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
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| Online Access: | http://jmums.mazums.ac.ir/article-1-21620-en.pdf |
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| author | Mina Safari Ramin Shabani Alireza Elmieh |
| author_facet | Mina Safari Ramin Shabani Alireza Elmieh |
| author_sort | Mina Safari |
| collection | DOAJ |
| description | Background and purpose: Aging is a complex process characterized by multiple cellular and molecular disorders, gradually leading to a decline in physiological and cognitive functions. In this context, the prevalence of obesity, a key factor that exacerbates these issues, is increasing. This study aimed to examine the impact of a combined exercise intervention on interleukin-10 levels, vascular endothelial growth factor (VEGF), the neutrophil-to-lymphocyte ratio, cognitive performance, and gait performance in obese elderly men.
Materials and methods: This randomized clinical trial (IRCT20200509047372N1) included 40 obese elderly men (mean age: 61.90± 2.84 years; BMI: 31.01 ± 1.53 kg/m²), who were randomly assigned to either an intervention group (n= 20) or a control group (n= 20). The intervention group participated in a combined exercise regimen for 16 weeks, with three sessions per week, each lasting 90 minutes. Plasma levels of interleukin-10, VEGF, and the neutrophil-to-lymphocyte ratio, as well as cognitive and gait performance, were measured 48 hours before and after the intervention. Data normality was assessed using the Shapiro-Wilk test, and statistical analysis was performed using paired t-tests and ANCOVA at a significance level of 0.05, with SPSS version 26.
Results: The findings indicated that the combined exercise intervention significantly improved cognitive and gait performance in the experimental group (P= 0.001). Additionally, interleukin-10 and VEGF levels increased significantly in the experimental group (P=0.001). However, no significant differences were observed in BMI or weight between the two groups (P> 0.05). Similarly, no significant changes were found in the neutrophil-to-lymphocyte ratio in either group (P > 0.05).
Conclusion: These findings suggest that combined exercise may enhance cognitive and gait performance while increasing interleukin-10 and VEGF levels in obese elderly men. However, this exercise intensity did not significantly affect the neutrophil-to-lymphocyte ratio.
(Clinical Trials Registry Number: IRCT20200509047372N1) |
| format | Article |
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| institution | OA Journals |
| issn | 1735-9260 1735-9279 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Mazandaran University of Medical Sciences |
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| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj-art-3bde80d355b24473bdd6236ea0e842732025-08-20T02:09:40ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792025-03-01352433952The Effect of Combined Aerobic-Resistance Exercise on Interleukin-10 Levels, Vascular Endothelial Growth Factor, Neutrophil-to-Lymphocyte Ratio, Cognitive and Walking Functions in Obese Elderly MenMina Safari0Ramin Shabani1Alireza Elmieh2 PhD Student in Exercise Physiology, Department of Physical Education and Sports Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran Professor in Exercise Physiology, Department of Physical Education and Sports Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran Associate Professor in Exercise Physiology, Department of Physical Education and Sports Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran Background and purpose: Aging is a complex process characterized by multiple cellular and molecular disorders, gradually leading to a decline in physiological and cognitive functions. In this context, the prevalence of obesity, a key factor that exacerbates these issues, is increasing. This study aimed to examine the impact of a combined exercise intervention on interleukin-10 levels, vascular endothelial growth factor (VEGF), the neutrophil-to-lymphocyte ratio, cognitive performance, and gait performance in obese elderly men. Materials and methods: This randomized clinical trial (IRCT20200509047372N1) included 40 obese elderly men (mean age: 61.90± 2.84 years; BMI: 31.01 ± 1.53 kg/m²), who were randomly assigned to either an intervention group (n= 20) or a control group (n= 20). The intervention group participated in a combined exercise regimen for 16 weeks, with three sessions per week, each lasting 90 minutes. Plasma levels of interleukin-10, VEGF, and the neutrophil-to-lymphocyte ratio, as well as cognitive and gait performance, were measured 48 hours before and after the intervention. Data normality was assessed using the Shapiro-Wilk test, and statistical analysis was performed using paired t-tests and ANCOVA at a significance level of 0.05, with SPSS version 26. Results: The findings indicated that the combined exercise intervention significantly improved cognitive and gait performance in the experimental group (P= 0.001). Additionally, interleukin-10 and VEGF levels increased significantly in the experimental group (P=0.001). However, no significant differences were observed in BMI or weight between the two groups (P> 0.05). Similarly, no significant changes were found in the neutrophil-to-lymphocyte ratio in either group (P > 0.05). Conclusion: These findings suggest that combined exercise may enhance cognitive and gait performance while increasing interleukin-10 and VEGF levels in obese elderly men. However, this exercise intensity did not significantly affect the neutrophil-to-lymphocyte ratio. (Clinical Trials Registry Number: IRCT20200509047372N1)http://jmums.mazums.ac.ir/article-1-21620-en.pdfinterleukin-10vegfcognitive functionwalking functionselderly obesecombined exercise |
| spellingShingle | Mina Safari Ramin Shabani Alireza Elmieh The Effect of Combined Aerobic-Resistance Exercise on Interleukin-10 Levels, Vascular Endothelial Growth Factor, Neutrophil-to-Lymphocyte Ratio, Cognitive and Walking Functions in Obese Elderly Men Journal of Mazandaran University of Medical Sciences interleukin-10 vegf cognitive function walking functions elderly obese combined exercise |
| title | The Effect of Combined Aerobic-Resistance Exercise on Interleukin-10 Levels, Vascular Endothelial Growth Factor, Neutrophil-to-Lymphocyte Ratio, Cognitive and Walking Functions in Obese Elderly Men |
| title_full | The Effect of Combined Aerobic-Resistance Exercise on Interleukin-10 Levels, Vascular Endothelial Growth Factor, Neutrophil-to-Lymphocyte Ratio, Cognitive and Walking Functions in Obese Elderly Men |
| title_fullStr | The Effect of Combined Aerobic-Resistance Exercise on Interleukin-10 Levels, Vascular Endothelial Growth Factor, Neutrophil-to-Lymphocyte Ratio, Cognitive and Walking Functions in Obese Elderly Men |
| title_full_unstemmed | The Effect of Combined Aerobic-Resistance Exercise on Interleukin-10 Levels, Vascular Endothelial Growth Factor, Neutrophil-to-Lymphocyte Ratio, Cognitive and Walking Functions in Obese Elderly Men |
| title_short | The Effect of Combined Aerobic-Resistance Exercise on Interleukin-10 Levels, Vascular Endothelial Growth Factor, Neutrophil-to-Lymphocyte Ratio, Cognitive and Walking Functions in Obese Elderly Men |
| title_sort | effect of combined aerobic resistance exercise on interleukin 10 levels vascular endothelial growth factor neutrophil to lymphocyte ratio cognitive and walking functions in obese elderly men |
| topic | interleukin-10 vegf cognitive function walking functions elderly obese combined exercise |
| url | http://jmums.mazums.ac.ir/article-1-21620-en.pdf |
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