Accelerated aging as a mediator of the association between co-exposure to multiple air pollutants and risk of chronic kidney disease
Background: The association between co-exposure to multiple air pollutants and the occurrence of chronic kidney disease (CKD) was not well-established, and the mediating role of accelerated aging in this association remained uncertain. Methods: Using a cohort of 313,908 participants without CKD at b...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324016580 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823856892820062208 |
|---|---|
| author | Shuo Zhang Yuxin Liu Jike Qi Yu Yan Tongyu Gao Xin Zhang Dong Sun Ting Wang Ping Zeng |
| author_facet | Shuo Zhang Yuxin Liu Jike Qi Yu Yan Tongyu Gao Xin Zhang Dong Sun Ting Wang Ping Zeng |
| author_sort | Shuo Zhang |
| collection | DOAJ |
| description | Background: The association between co-exposure to multiple air pollutants and the occurrence of chronic kidney disease (CKD) was not well-established, and the mediating role of accelerated aging in this association remained uncertain. Methods: Using a cohort of 313,908 participants without CKD at baseline from the UK Biobank, we examined the potential association between co-exposure to multiple air pollutants, including PM2.5, PM10, PM2.5–10, NO2 and NOx, and the incidence of CKD by calculating an air pollution score. Mediation analyses were performed to examine the mediating role of accelerated aging (PhenoAgeAccel or KDM-BioAgeAccel) in this association. Results: During the median follow-up time of 12.9 years, 11,117 participants developed CKD. The results showed that per interquartile range (IQR) increment in air pollution score led to an approximately 9.0 % (6.6–11.4 %) elevated risk of occurring CKD. Compared to the first quartile (Q1) of air pollution score, those in the highest quartile (Q4) had a 21.2 % (14.8–27.9 %) higher risk of developing CKD (Ptrend<0.001). Mediation analyses suggested that PhenoAgeAccel and KDM-BioAgeAccel significantly mediated 1.5 % and 5.7 % of the association between air pollution score and incident CKD, respectively. Conclusion: Co-exposure to multiple air pollutants could increase the risk of developing CKD, with accelerated aging serving as a partial mechanism in the relationship between air pollution and CKD. These findings highlight the importance of reducing air pollution, and suggest a possible mechanism from air pollution to CKD through accelerated aging. |
| format | Article |
| id | doaj-art-3bdda5cc3c86453c83323fb7c33349d4 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-3bdda5cc3c86453c83323fb7c33349d42025-02-12T05:29:53ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117582Accelerated aging as a mediator of the association between co-exposure to multiple air pollutants and risk of chronic kidney diseaseShuo Zhang0Yuxin Liu1Jike Qi2Yu Yan3Tongyu Gao4Xin Zhang5Dong Sun6Ting Wang7Ping Zeng8Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu 221004, ChinaDepartment of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu 221004, ChinaDepartment of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu 221004, ChinaDepartment of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu 221004, ChinaDepartment of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu 221004, ChinaDepartment of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu 221004, ChinaDepartment of Nephrology and Clinical Research Center for Kidney Disease, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221004, China; Clinical Research Center for Kidney Disease, Xuzhou Medical University, Xuzhou 221004, ChinaDepartment of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu 221004, ChinaDepartment of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; Correspondence to: Department of Biostatistics and Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.Background: The association between co-exposure to multiple air pollutants and the occurrence of chronic kidney disease (CKD) was not well-established, and the mediating role of accelerated aging in this association remained uncertain. Methods: Using a cohort of 313,908 participants without CKD at baseline from the UK Biobank, we examined the potential association between co-exposure to multiple air pollutants, including PM2.5, PM10, PM2.5–10, NO2 and NOx, and the incidence of CKD by calculating an air pollution score. Mediation analyses were performed to examine the mediating role of accelerated aging (PhenoAgeAccel or KDM-BioAgeAccel) in this association. Results: During the median follow-up time of 12.9 years, 11,117 participants developed CKD. The results showed that per interquartile range (IQR) increment in air pollution score led to an approximately 9.0 % (6.6–11.4 %) elevated risk of occurring CKD. Compared to the first quartile (Q1) of air pollution score, those in the highest quartile (Q4) had a 21.2 % (14.8–27.9 %) higher risk of developing CKD (Ptrend<0.001). Mediation analyses suggested that PhenoAgeAccel and KDM-BioAgeAccel significantly mediated 1.5 % and 5.7 % of the association between air pollution score and incident CKD, respectively. Conclusion: Co-exposure to multiple air pollutants could increase the risk of developing CKD, with accelerated aging serving as a partial mechanism in the relationship between air pollution and CKD. These findings highlight the importance of reducing air pollution, and suggest a possible mechanism from air pollution to CKD through accelerated aging.http://www.sciencedirect.com/science/article/pii/S0147651324016580Multiple air pollutantsChronic kidney diseaseAccelerated agingMediation analysis |
| spellingShingle | Shuo Zhang Yuxin Liu Jike Qi Yu Yan Tongyu Gao Xin Zhang Dong Sun Ting Wang Ping Zeng Accelerated aging as a mediator of the association between co-exposure to multiple air pollutants and risk of chronic kidney disease Ecotoxicology and Environmental Safety Multiple air pollutants Chronic kidney disease Accelerated aging Mediation analysis |
| title | Accelerated aging as a mediator of the association between co-exposure to multiple air pollutants and risk of chronic kidney disease |
| title_full | Accelerated aging as a mediator of the association between co-exposure to multiple air pollutants and risk of chronic kidney disease |
| title_fullStr | Accelerated aging as a mediator of the association between co-exposure to multiple air pollutants and risk of chronic kidney disease |
| title_full_unstemmed | Accelerated aging as a mediator of the association between co-exposure to multiple air pollutants and risk of chronic kidney disease |
| title_short | Accelerated aging as a mediator of the association between co-exposure to multiple air pollutants and risk of chronic kidney disease |
| title_sort | accelerated aging as a mediator of the association between co exposure to multiple air pollutants and risk of chronic kidney disease |
| topic | Multiple air pollutants Chronic kidney disease Accelerated aging Mediation analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324016580 |
| work_keys_str_mv | AT shuozhang acceleratedagingasamediatoroftheassociationbetweencoexposuretomultipleairpollutantsandriskofchronickidneydisease AT yuxinliu acceleratedagingasamediatoroftheassociationbetweencoexposuretomultipleairpollutantsandriskofchronickidneydisease AT jikeqi acceleratedagingasamediatoroftheassociationbetweencoexposuretomultipleairpollutantsandriskofchronickidneydisease AT yuyan acceleratedagingasamediatoroftheassociationbetweencoexposuretomultipleairpollutantsandriskofchronickidneydisease AT tongyugao acceleratedagingasamediatoroftheassociationbetweencoexposuretomultipleairpollutantsandriskofchronickidneydisease AT xinzhang acceleratedagingasamediatoroftheassociationbetweencoexposuretomultipleairpollutantsandriskofchronickidneydisease AT dongsun acceleratedagingasamediatoroftheassociationbetweencoexposuretomultipleairpollutantsandriskofchronickidneydisease AT tingwang acceleratedagingasamediatoroftheassociationbetweencoexposuretomultipleairpollutantsandriskofchronickidneydisease AT pingzeng acceleratedagingasamediatoroftheassociationbetweencoexposuretomultipleairpollutantsandriskofchronickidneydisease |