A Novel Rat Model of Type 2 Diabetes: The Zucker Fatty Diabetes Mellitus ZFDM Rat

A Novel Rat Model of Type 2 Diabetes: The Zucker Fatty Diabetes Mellitus ZFDM Rat

The Zucker fatty (ZF) rat harboring a missense mutation (fatty, fa) in the leptin receptor gene (Lepr) develops obesity without diabetes; Zucker diabetic fatty (ZDF) rats derived from the ZF strain exhibit obesity with diabetes and are widely used for research on type 2 diabetes (T2D). Here we estab...

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Bibliographic Details
Main Authors: Norihide Yokoi, Masayuki Hoshino, Shihomi Hidaka, Eri Yoshida, Masayuki Beppu, Ritsuko Hoshikawa, Katsuko Sudo, Akihiko Kawada, Sadaaki Takagi, Susumu Seino
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2013/103731
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