The Progress in Exploratory Studies of Peripheral Blood Single Nucleated Cells as Seed Cells in Peripheral Nerve Repair
Peripheral nerve injury (PNI) represents a prevalent clinical condition, often resulting from mechanical trauma or tumor resection, which frequently induces persistent sensory deficits, motor impairment, neuropathic pain, or paralysis. Consequently, substantial socioeconomic burdens are imposed on a...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/np/8895041 |
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| author | Yi Chen Yubin Wen Mingyue Zhang Jing Nie Guangfeng Sun |
| author_facet | Yi Chen Yubin Wen Mingyue Zhang Jing Nie Guangfeng Sun |
| author_sort | Yi Chen |
| collection | DOAJ |
| description | Peripheral nerve injury (PNI) represents a prevalent clinical condition, often resulting from mechanical trauma or tumor resection, which frequently induces persistent sensory deficits, motor impairment, neuropathic pain, or paralysis. Consequently, substantial socioeconomic burdens are imposed on affected individuals. Autologous nerve transplantation is often considered the preferred approach for reconstructing peripheral nerve defects; however, this technique is associated with limitations including donor-site sensory loss, restricted graft length, and nerve mismatches. Recently, peripheral blood mononuclear cells (PBMCs) have emerged as a focal point in nerve regeneration research due to their accessibility, immunomodulatory properties, and neuro-reparative potential. Nevertheless, the precise mechanisms underlying PBMC-mediated nerve repair remain incompletely characterized, and their molecular pathways require further elucidation. This study explores the potential role of PBMCs in promoting peripheral nerve regeneration, with a particular focus on their regulation of retrograde brain-derived neurotrophic factor (BDNF) transport through modulation of Hook1 expression and associated molecular pathways. This research seeks to provide novel insights for PBMC-based therapeutic strategies and establish a theoretical foundation for clinical translation. Implementation challenges and translational prospects for PBMCs in nerve regeneration are also critically evaluated. |
| format | Article |
| id | doaj-art-3bcfc0664cd344e28decf64d011ea0f9 |
| institution | Kabale University |
| issn | 1687-5443 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-3bcfc0664cd344e28decf64d011ea0f92025-08-20T03:36:58ZengWileyNeural Plasticity1687-54432025-01-01202510.1155/np/8895041The Progress in Exploratory Studies of Peripheral Blood Single Nucleated Cells as Seed Cells in Peripheral Nerve RepairYi Chen0Yubin Wen1Mingyue Zhang2Jing Nie3Guangfeng Sun4Department of Burns and Plastic SurgeryDepartment of Burns and Plastic SurgeryDepartment of Burns and Plastic SurgeryKey Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of EducationDepartment of Burns and Plastic SurgeryPeripheral nerve injury (PNI) represents a prevalent clinical condition, often resulting from mechanical trauma or tumor resection, which frequently induces persistent sensory deficits, motor impairment, neuropathic pain, or paralysis. Consequently, substantial socioeconomic burdens are imposed on affected individuals. Autologous nerve transplantation is often considered the preferred approach for reconstructing peripheral nerve defects; however, this technique is associated with limitations including donor-site sensory loss, restricted graft length, and nerve mismatches. Recently, peripheral blood mononuclear cells (PBMCs) have emerged as a focal point in nerve regeneration research due to their accessibility, immunomodulatory properties, and neuro-reparative potential. Nevertheless, the precise mechanisms underlying PBMC-mediated nerve repair remain incompletely characterized, and their molecular pathways require further elucidation. This study explores the potential role of PBMCs in promoting peripheral nerve regeneration, with a particular focus on their regulation of retrograde brain-derived neurotrophic factor (BDNF) transport through modulation of Hook1 expression and associated molecular pathways. This research seeks to provide novel insights for PBMC-based therapeutic strategies and establish a theoretical foundation for clinical translation. Implementation challenges and translational prospects for PBMCs in nerve regeneration are also critically evaluated.http://dx.doi.org/10.1155/np/8895041 |
| spellingShingle | Yi Chen Yubin Wen Mingyue Zhang Jing Nie Guangfeng Sun The Progress in Exploratory Studies of Peripheral Blood Single Nucleated Cells as Seed Cells in Peripheral Nerve Repair Neural Plasticity |
| title | The Progress in Exploratory Studies of Peripheral Blood Single Nucleated Cells as Seed Cells in Peripheral Nerve Repair |
| title_full | The Progress in Exploratory Studies of Peripheral Blood Single Nucleated Cells as Seed Cells in Peripheral Nerve Repair |
| title_fullStr | The Progress in Exploratory Studies of Peripheral Blood Single Nucleated Cells as Seed Cells in Peripheral Nerve Repair |
| title_full_unstemmed | The Progress in Exploratory Studies of Peripheral Blood Single Nucleated Cells as Seed Cells in Peripheral Nerve Repair |
| title_short | The Progress in Exploratory Studies of Peripheral Blood Single Nucleated Cells as Seed Cells in Peripheral Nerve Repair |
| title_sort | progress in exploratory studies of peripheral blood single nucleated cells as seed cells in peripheral nerve repair |
| url | http://dx.doi.org/10.1155/np/8895041 |
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