Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives
For hundreds of years, the drug discovery and development industry has aimed at identifying single components with a clear mechanism of action as desirable candidates for potential drugs. However, this conventional strategy of drug discovery and development has faced challenges including a low succe...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Compuscript Ltd
2023-02-01
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| Series: | Acta Materia Medica |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0049 |
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| _version_ | 1850121963685543936 |
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| author | Cheng Zhang Guoming Chen Guoyi Tang Xiaoyu Xu Zixin Feng Yuanjun Lu Yau-Tuen Chan Junyu Wu Yuanyuan Chen Lin Xu QING REN Hongchao Yuan Dong-Hua Yang Zhe-Sheng Chen Ning Wang Yibin Feng |
| author_facet | Cheng Zhang Guoming Chen Guoyi Tang Xiaoyu Xu Zixin Feng Yuanjun Lu Yau-Tuen Chan Junyu Wu Yuanyuan Chen Lin Xu QING REN Hongchao Yuan Dong-Hua Yang Zhe-Sheng Chen Ning Wang Yibin Feng |
| author_sort | Cheng Zhang |
| collection | DOAJ |
| description | For hundreds of years, the drug discovery and development industry has aimed at identifying single components with a clear mechanism of action as desirable candidates for potential drugs. However, this conventional strategy of drug discovery and development has faced challenges including a low success rate and high development costs. Herein, we critically review state-of-the-art drug discovery and development based on multi-component Chinese medicine formulas. We review the policies and application status of new drugs based on multi-component Chinese medicines in the US, China, and the European Union. Moreover, we illustrate several excellent cases of ongoing applications. Biomedical technologies that may facilitate drug discovery and development based on multi-component Chinese medicine formulas are discussed, including network pharmacology, integrative omics, CRISPR gene editing, and chemometrics. Finally, we discuss potential problems and solutions in pre-clinical and clinical research in drug discovery and development based on multi-component Chinese medicine formulas. We hope that this review will promote discussion of the roles of multi-component Chinese medicine formulas in the discovery and development of new drugs for the treatment of human diseases. |
| format | Article |
| id | doaj-art-3bbf4451b9ad4428993aa1d7704240e6 |
| institution | OA Journals |
| issn | 2737-7946 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | Acta Materia Medica |
| spelling | doaj-art-3bbf4451b9ad4428993aa1d7704240e62025-08-20T02:34:56ZengCompuscript LtdActa Materia Medica2737-79462023-02-012110612510.15212/AMM-2022-0049Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectivesCheng ZhangGuoming ChenGuoyi TangXiaoyu XuZixin FengYuanjun LuYau-Tuen ChanJunyu WuYuanyuan ChenLin XuQING RENHongchao YuanDong-Hua YangZhe-Sheng ChenNing WangYibin FengFor hundreds of years, the drug discovery and development industry has aimed at identifying single components with a clear mechanism of action as desirable candidates for potential drugs. However, this conventional strategy of drug discovery and development has faced challenges including a low success rate and high development costs. Herein, we critically review state-of-the-art drug discovery and development based on multi-component Chinese medicine formulas. We review the policies and application status of new drugs based on multi-component Chinese medicines in the US, China, and the European Union. Moreover, we illustrate several excellent cases of ongoing applications. Biomedical technologies that may facilitate drug discovery and development based on multi-component Chinese medicine formulas are discussed, including network pharmacology, integrative omics, CRISPR gene editing, and chemometrics. Finally, we discuss potential problems and solutions in pre-clinical and clinical research in drug discovery and development based on multi-component Chinese medicine formulas. We hope that this review will promote discussion of the roles of multi-component Chinese medicine formulas in the discovery and development of new drugs for the treatment of human diseases.https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0049 |
| spellingShingle | Cheng Zhang Guoming Chen Guoyi Tang Xiaoyu Xu Zixin Feng Yuanjun Lu Yau-Tuen Chan Junyu Wu Yuanyuan Chen Lin Xu QING REN Hongchao Yuan Dong-Hua Yang Zhe-Sheng Chen Ning Wang Yibin Feng Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives Acta Materia Medica |
| title | Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives |
| title_full | Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives |
| title_fullStr | Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives |
| title_full_unstemmed | Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives |
| title_short | Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives |
| title_sort | multi component chinese medicine formulas for drug discovery state of the art and future perspectives |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0049 |
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