Nummular retinal pigment epithelium loss in bilateral diffuse uveal melanocytic proliferation
A rare case of cancer-associated nummular loss of retinal pigment epithelium (RPE) is presented. This subtype of the more commonly reported bilateral diffuse uveal melanocytic proliferation is notable for absence of typical uveal melanocytic proliferation. A 71-year-old male with pancreatic cancer e...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Journal of Clinical Ophthalmology and Research |
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| Online Access: | https://journals.lww.com/10.4103/jcor.jcor_83_24 |
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| author | Neha Goel |
| author_facet | Neha Goel |
| author_sort | Neha Goel |
| collection | DOAJ |
| description | A rare case of cancer-associated nummular loss of retinal pigment epithelium (RPE) is presented. This subtype of the more commonly reported bilateral diffuse uveal melanocytic proliferation is notable for absence of typical uveal melanocytic proliferation. A 71-year-old male with pancreatic cancer exhibited multiple hypopigmented patches on fundus examination, with corresponding transmission defects on fluorescein angiography and outer retinal and RPE loss on optical coherence tomography, confirming RPE loss as the predominant feature. This was interspersed with zones of preserved RPE which were most prominent on near-infrared reflectance imaging. Recognition of this unusual variant is important to establish an early diagnosis. |
| format | Article |
| id | doaj-art-3bbe0ba297b34ec7a99626619d90c65c |
| institution | Kabale University |
| issn | 2320-3897 2320-3900 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical Ophthalmology and Research |
| spelling | doaj-art-3bbe0ba297b34ec7a99626619d90c65c2025-02-06T06:38:52ZengWolters Kluwer Medknow PublicationsJournal of Clinical Ophthalmology and Research2320-38972320-39002025-01-0113111111310.4103/jcor.jcor_83_24Nummular retinal pigment epithelium loss in bilateral diffuse uveal melanocytic proliferationNeha GoelA rare case of cancer-associated nummular loss of retinal pigment epithelium (RPE) is presented. This subtype of the more commonly reported bilateral diffuse uveal melanocytic proliferation is notable for absence of typical uveal melanocytic proliferation. A 71-year-old male with pancreatic cancer exhibited multiple hypopigmented patches on fundus examination, with corresponding transmission defects on fluorescein angiography and outer retinal and RPE loss on optical coherence tomography, confirming RPE loss as the predominant feature. This was interspersed with zones of preserved RPE which were most prominent on near-infrared reflectance imaging. Recognition of this unusual variant is important to establish an early diagnosis.https://journals.lww.com/10.4103/jcor.jcor_83_24bilateral diffuse uveal melanocytic proliferationcancer-associated retinopathynummular loss of retinal pigment epitheliumparaneoplastic retinopathy |
| spellingShingle | Neha Goel Nummular retinal pigment epithelium loss in bilateral diffuse uveal melanocytic proliferation Journal of Clinical Ophthalmology and Research bilateral diffuse uveal melanocytic proliferation cancer-associated retinopathy nummular loss of retinal pigment epithelium paraneoplastic retinopathy |
| title | Nummular retinal pigment epithelium loss in bilateral diffuse uveal melanocytic proliferation |
| title_full | Nummular retinal pigment epithelium loss in bilateral diffuse uveal melanocytic proliferation |
| title_fullStr | Nummular retinal pigment epithelium loss in bilateral diffuse uveal melanocytic proliferation |
| title_full_unstemmed | Nummular retinal pigment epithelium loss in bilateral diffuse uveal melanocytic proliferation |
| title_short | Nummular retinal pigment epithelium loss in bilateral diffuse uveal melanocytic proliferation |
| title_sort | nummular retinal pigment epithelium loss in bilateral diffuse uveal melanocytic proliferation |
| topic | bilateral diffuse uveal melanocytic proliferation cancer-associated retinopathy nummular loss of retinal pigment epithelium paraneoplastic retinopathy |
| url | https://journals.lww.com/10.4103/jcor.jcor_83_24 |
| work_keys_str_mv | AT nehagoel nummularretinalpigmentepitheliumlossinbilateraldiffuseuvealmelanocyticproliferation |