Integrating in situ vaccination with checkpoint blockade therapy: a novel approach to enhance anti-tumour immunity in colorectal cancer

Integrating in situ vaccination with checkpoint blockade therapy: a novel approach to enhance anti-tumour immunity in colorectal cancer

Colorectal cancer (CRC) remains a challenging disease due to its high diversity and complex immune escape mechanisms. The anticipated incidence of colorectal cancer is expected to reach 3,200,000 new cases per year, indicating a 63% increase, with an estimated 1,600,000 deaths occurring annually, wh...

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Bibliographic Details
Main Authors: Tolulope A. Owolabi, Samson A. Adeyemi, Lindokuhle M. Ngema, Clement Penny, Yahya E. Choonara
Format: Article
Language:English
Published: ELS Publishing (ELSP) 2025-05-01
Series:Biofunctional Materials
Subjects:
colorectal cancer
immunotherapy
immune checkpoint inhibitors
in situ vaccination
combination therapy
therapeutic peptides
pd-1/pd-l1 inhibitors
dendritic cells
Online Access:https://elsp-homepage.oss-cn-hongkong.aliyuncs.compaper/journal/open/BM/2025/bm20250007.pdf
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